An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years

	An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years
	Li, Chun-Huan 1; Zhang, Jia-Yao 1; Zhang, Xiu-Yun 1; Li, Sheng-Hong2 ; Gao, Jin-Ming 1
	2019-03-15
发表期刊	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN	0223-5234
卷号	166 页码:400-416
摘要	Grayanane diterpenoids, possessing a unique 5/7/6/5 tetracyclic system, exist exclusively in plants of the Ericaceae family. Owing to their various skeletons, complex structures, and diverse bioactivities, grayanoids have been the topic of research in many phytochemical and pharmacological laboratories, offering opportunities for the development of new drugs with analgesic, anti-inflammatory, and protein tyrosine phosphatase 1B (PTP1B) properties. Recently, a number of new grayanane diterpenoids with unprecedented carbon skeletons have been obtained from plants of the Ericaceae family, and they exhibit diverse biological properties, such as agalgesic, antinociceptive, anticancer, antiviral, antifeedant, insecticidal, toxicity, and PTP1B. In this review, 162 new grayanoids with 14 carbon skeletons from the Ericaceae family over the past seven years (2012 October 2018) are discussed, including their occurrence and distribution, skeleton types, structural features, biological activities, and structure-activity relationships (SARs). Also, strategies for the structural elucidation are summarized to provide useful information for medicinal chemists in developing potent anticancer, antiviral, analgesic, anti-inflammatory, and novel PTP1B agents. (C) 2019 Elsevier Masson SAS. All rights reserved.
关键词	Grayanane diterpenoids Ericaceae Bioactivities Analgesic activity Anti-inflammatory activity PTP1B inhibitory activity Structure-activity relationship
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/65190
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Sheng-Hong; Gao, Jin-Ming
作者单位	1.Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Chun-Huan,Zhang, Jia-Yao,Zhang, Xiu-Yun,et al. An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2019,166:400-416.
APA	Li, Chun-Huan,Zhang, Jia-Yao,Zhang, Xiu-Yun,Li, Sheng-Hong,&Gao, Jin-Ming.(2019).An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,166,400-416.
MLA	Li, Chun-Huan,et al."An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 166(2019):400-416.

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