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Induction of RIPK3/MLKL-mediated necroptosis by Erigeron breviscapus injection exhibits potent antitumor effect 期刊论文
FRONTIERS IN PHARMACOLOGY, 2023, 卷号: 14, 页码: 1219362
作者:  Guo,Xiuping;  Li,Rui;  Cui,Jinjin;  Hu,Chujuan;  Yu,Haoyang;  Ren,Ling;  Cheng,Yangyang;  Jiang,Jiandong;  Ding,Xiao;  Wang,Lulu
浏览  |  Adobe PDF(7660Kb)  |  收藏  |  浏览/下载：37/9  |  提交时间：2024/05/09
Erigeron Breviscapus Injection  Dengzhanxixin  Erigeron Breviscapus (Vant  ) Hand  -mazz  Colorectal Cancer  Necroptosis  Drug Resistance  Tumor-necrosis-factor  Colorectal-cancer  Natural Compounds  Scutellarin  Apoptosis  Proliferation  Macrophages  Migration  Invasion  Therapy  
雷公藤制剂对消化系统的毒性机理研究 学位论文
: 中国科学院大学, 2022
作者:  代曼云
Adobe PDF(10574Kb)  |  收藏  |  浏览/下载：11/0  |  提交时间：2024/05/14
代谢组学，雷公藤，药源性肝损伤，消化性溃疡，FXR，ET-1， 肠道血管屏障  Metabolomics, Tripterygium wilfordii, Drug-induced liver injury, peptic ulcer disease, FXR, ET-1, intestinal vascular barrier.  
A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses 期刊论文
JOURNAL OF NANOBIOTECHNOLOGY, 2022, 卷号: 20, 期号: 1, 页码: 320
作者:  Chen, Sisi;  Yang, Liu;  Ou, Xia;  Li, Jin-Yu;  Zi, Cheng-Ting;  Wang, Hao;  Hu, Jiang-Miao;  Liu, Ye
浏览  |  Adobe PDF(7638Kb)  |  收藏  |  浏览/下载：26/9  |  提交时间：2024/04/30
Polysaccharide  Self-adjuvant  Nanovaccine  SARS-CoV-2  HIV  STRUCTURAL-CHARACTERIZATION  DENDRITIC CELLS  DRUG-DELIVERY  NANOPARTICLES  PARTICLES  CHITOSAN  GLYCOGEN  DESIGN  
Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort 期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 12, 期号: 34, 页码: 11438-11446
作者:  Guo,Yi;  Huang,Fang;  Sun,Weiguang;  Zhou,Yuan;  Chen,Chunmei;  Qi,Changxing;  Yang,Jing;  Li,Xiao-Nian;  Luo,Zengwei;  Zhu,Hucheng;  Wang,Xiaochuan;  Zhang,Yonghui
收藏  |  浏览/下载：108/0  |  提交时间：2022/04/02
AMYLOID-BETA  NEUROFIBRILLARY DEGENERATION  HYPERFORIN  NEUROTOXICITY  PATHOGENESIS  INHIBITION  BACE1  DRUG  TAU  
Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr. 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 卷号: 19, 期号: 44, 页码: 9637-9640
作者:  Liu,Shuai;  Zhang,Cui-Shan;  Ran,Xiao-Qian;  Tang,Xiao-Han;  Guo,Ya-Rong;  Yan,Ying;  Yao,Yong-Gang;  Hao,Xiao-Jiang;  Luo,Rong-Can;  Di,Ying-Tong
浏览  |  Adobe PDF(997Kb)  |  收藏  |  浏览/下载：116/37  |  提交时间：2022/04/02
PROMISING BIOLOGICAL-ACTIVITY  LIMONOIDS  CHROMONES  FRUITS  DRUG  
Chemical Synthesis of the Nucleoside Antibiotic Capuramycin 期刊论文
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 2021, 期号: 26, 页码: 3681-3689
作者:  Xiao,Guozhi;  He,Haiqing
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Capuramycin  Chemical synthesis  Glycosyl ortho-(1-phenylvinyl)benzoates  One-pot glycosylation  Tuberculosis  DRUG-RESISTANT TUBERCULOSIS  GLUTAMIC-ACID-DERIVATIVES  MULTIDRUG-RESISTANT  PROTECTING GROUPS  IN-VITRO  GLYCOSYLATION  INHIBITORS  ALCOHOLS  ANALOGS  OXIDATION  
Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus 期刊论文
ZOOLOGICAL RESEARCH, 2021, 卷号: 42, 期号: 1, 页码: 28-42
作者:  Zhang,Chuan-Ling;  Li,Yi-Jia;  Lu,Shuang;  Zhang,Ting;  Xiao,Rui;  Luo,Huai-Rong
浏览  |  Adobe PDF(11037Kb)  |  收藏  |  浏览/下载：136/15  |  提交时间：2022/04/02
Depression  Elderly  Fluoxetine  LncRNA  Chronic unpredictable mild stress  LONG NONCODING RNA  NEUROTROPHIC FACTOR  MAJOR DEPRESSION  MILD STRESS  DRUG-NAIVE  PROTEIN  INFLAMMATION  MECHANISMS  BIOMARKERS  DISCOVERY  
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
浏览  |  Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：210/32  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors 期刊论文
PHARMACEUTICS, 2019, 卷号: 11, 期号: 9, 页码: 16
作者:  Sajesh, Babu, V;  On, Ngoc H.;  Omar, Refaat;  Alrushaid, Samaa;  Kopec, Brian M.;  Wang, Wei-Guang;  Sun, Han-Dong;  Lillico, Ryan;  Lakowski, Ted M.;  Siahaan, Teruna J.;  Davies, Neal M.;  Puno, Pema-Tenzin;  Vanan, Magimairajan Issai;  Miller, Donald W.
浏览  |  Adobe PDF(3895Kb)  |  收藏  |  浏览/下载：223/55  |  提交时间：2019/12/20
blood-brain barrier (BBB)  drug delivery  transient modulation  HAV6 cadherin peptide  adenanthin  magnetic resonance imaging (MRI)  medulloblastoma  
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity 期刊论文
BMC Cancer, 2019, 卷号: 19, 期号: 1
作者:  Wang,Ning;  Fan,Yanhua;  Yuan,Chun-Mao;  Song,Jialei;  Yao,Yao;  Liu,Wuling;  Gajendran,Babu;  Zacksenhaus,Eldad;  Li,Yanmei;  Liu,Jielin;  Hao,Xiao Jiang;  Ben-David,Yaacov
收藏  |  浏览/下载：151/0  |  提交时间：2019/08/13
Cancer  Leukemia  Chinese medicinal plant  Melia azedarach  Drug screen  ERK1/2 agonists  Differentiation  Apoptosis