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Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr. | |
Liu,Shuai; Zhang,Cui-Shan; Ran,Xiao-Qian; Tang,Xiao-Han; Guo,Ya-Rong; Yan,Ying; Yao,Yong-Gang; Hao,Xiao-Jiang![]() | |
2021 | |
Source Publication | ORGANIC & BIOMOLECULAR CHEMISTRY
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ISSN | 1477-0520 |
Volume | 19Issue:44Pages:9637-9640 |
Abstract | Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1 alpha,12 alpha:5 alpha,13 alpha-dicyclo-9 beta H-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes. |
Keyword | PROMISING BIOLOGICAL-ACTIVITY LIMONOIDS CHROMONES FRUITS DRUG |
DOI | 10.1039/d1ob01927a |
WOS ID | WOS:000712551000001 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.kib.ac.cn/handle/151853/73723 |
Collection | 中国科学院昆明植物研究所 |
Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Chinese Acad Sci & Yunnan Prov,Kunming Inst Zool, Kunming 650204, Yunnan, Peoples R China 4.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei 230026, Peoples R China 5.Guizhou Med Univ, Guizhou Chem Drug Res & Dev Engn Tech Ctr, Guiyang 550004, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China |
Recommended Citation GB/T 7714 | Liu,Shuai,Zhang,Cui-Shan,Ran,Xiao-Qian,et al. Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021,19(44):9637-9640. |
APA | Liu,Shuai.,Zhang,Cui-Shan.,Ran,Xiao-Qian.,Tang,Xiao-Han.,Guo,Ya-Rong.,...&Di,Ying-Tong.(2021).Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr..ORGANIC & BIOMOLECULAR CHEMISTRY,19(44),9637-9640. |
MLA | Liu,Shuai,et al."Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.".ORGANIC & BIOMOLECULAR CHEMISTRY 19.44(2021):9637-9640. |
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