Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

doi:10.1039/d1ob01927a

KIB OpenIR

	Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.
	Liu,Shuai ; Zhang,Cui-Shan ; Ran,Xiao-Qian ; Tang,Xiao-Han ; Guo,Ya-Rong ; Yan,Ying ; Yao,Yong-Gang ; Hao,Xiao-Jiang; Luo,Rong-Can ; Di,Ying-Tong
	2021
Source Publication	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0520
Volume	19 Issue:44 Pages:9637-9640
Abstract	Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1 alpha,12 alpha:5 alpha,13 alpha-dicyclo-9 beta H-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.
Keyword	PROMISING BIOLOGICAL-ACTIVITY LIMONOIDS CHROMONES FRUITS DRUG
DOI	10.1039/d1ob01927a
WOS ID	WOS:000712551000001
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73723
Collection	中国科学院昆明植物研究所
Affiliation	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Chinese Acad Sci & Yunnan Prov,Kunming Inst Zool, Kunming 650204, Yunnan, Peoples R China 4.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei 230026, Peoples R China 5.Guizhou Med Univ, Guizhou Chem Drug Res & Dev Engn Tech Ctr, Guiyang 550004, Peoples R China 6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
Recommended Citation GB/T 7714	Liu,Shuai,Zhang,Cui-Shan,Ran,Xiao-Qian,et al. Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021,19(44):9637-9640.
APA	Liu,Shuai.,Zhang,Cui-Shan.,Ran,Xiao-Qian.,Tang,Xiao-Han.,Guo,Ya-Rong.,...&Di,Ying-Tong.(2021).Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr..ORGANIC & BIOMOLECULAR CHEMISTRY,19(44),9637-9640.
MLA	Liu,Shuai,et al."Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.".ORGANIC & BIOMOLECULAR CHEMISTRY 19.44(2021):9637-9640.

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