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Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.
Liu,Shuai; Zhang,Cui-Shan; Ran,Xiao-Qian; Tang,Xiao-Han; Guo,Ya-Rong; Yan,Ying; Yao,Yong-Gang; Hao,Xiao-Jiang; Luo,Rong-Can; Di,Ying-Tong
2021
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
Volume19Issue:44Pages:9637-9640
AbstractTwo new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1 alpha,12 alpha:5 alpha,13 alpha-dicyclo-9 beta H-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.
KeywordPROMISING BIOLOGICAL-ACTIVITY LIMONOIDS CHROMONES FRUITS DRUG
DOI10.1039/d1ob01927a
WOS IDWOS:000712551000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73723
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Chinese Acad Sci & Yunnan Prov,Kunming Inst Zool, Kunming 650204, Yunnan, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei 230026, Peoples R China
5.Guizhou Med Univ, Guizhou Chem Drug Res & Dev Engn Tech Ctr, Guiyang 550004, Peoples R China
6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Liu,Shuai,Zhang,Cui-Shan,Ran,Xiao-Qian,et al. Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021,19(44):9637-9640.
APA Liu,Shuai.,Zhang,Cui-Shan.,Ran,Xiao-Qian.,Tang,Xiao-Han.,Guo,Ya-Rong.,...&Di,Ying-Tong.(2021).Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr..ORGANIC & BIOMOLECULAR CHEMISTRY,19(44),9637-9640.
MLA Liu,Shuai,et al."Perforatactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.".ORGANIC & BIOMOLECULAR CHEMISTRY 19.44(2021):9637-9640.
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