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Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 210, 页码: 113068
作者:  Dai,Zhi;  Liu,Hui;  Wang,Bei;  Yang,Dong;  Zhu,Yan-Yan;  Yan,Huan;  Zhu,Pei-Feng;  Liu,Ya-Ping;  Chen,Hui-Cheng;  Zhao,Yun-li;  Zhao,Li-Xing;  Zhao,Xu-Dong;  Liu,Hai-Yang;  Luo,Xiao-Dong
浏览  |  Adobe PDF(2630Kb)  |  收藏  |  浏览/下载：168/86  |  提交时间：2022/04/02
Steroidal saponins  Structure-activity relationship  Tribulosaponin A  Glioma stem cells  ROS  SMALL MOLECULES  CARDIAC-ARREST  STEM-CELL  IDENTIFICATION  THERAPY  BRAIN  OPPORTUNITIES  GLIOMA  TUMORS  NOX2  
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
浏览  |  Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：105/33  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2021, 卷号: 90, 页码: 107405
作者:  Jiang,Xuan;  Li,Shuxiang;  Zhang,Hongbin;  Wang,Liang-Liang
浏览  |  Adobe PDF(6441Kb)  |  收藏  |  浏览/下载：103/18  |  提交时间：2022/04/02
mu-Opioid receptors (MOR)  Biased ligands  Molecular docking  Hip-hop pharmacophore  MD simulation  
Actein Inhibits Tumor Growth and Metastasis in HER2-Positive Breast Tumor Bearing Mice via Suppressing AKT/mTOR and Ras/Raf/MAPK Signaling Pathways 期刊论文
FRONTIERS IN ONCOLOGY, 2020
作者:  Wu, Xiao-Xiao;  Yue, Grace Gar-Lee;  Dong, Jin-Run;  Lam, Christopher Wai-Kei;  Wong, Chun-Kwok;  Qiu, Ming-Hua;  Lau, Clara Bik-San
浏览  |  Adobe PDF(1739Kb)  |  收藏  |  浏览/下载：187/77  |  提交时间：2021/01/05
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
浏览  |  Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：210/32  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors 期刊论文
PHARMACEUTICS, 2019, 卷号: 11, 期号: 9, 页码: 16
作者:  Sajesh, Babu, V;  On, Ngoc H.;  Omar, Refaat;  Alrushaid, Samaa;  Kopec, Brian M.;  Wang, Wei-Guang;  Sun, Han-Dong;  Lillico, Ryan;  Lakowski, Ted M.;  Siahaan, Teruna J.;  Davies, Neal M.;  Puno, Pema-Tenzin;  Vanan, Magimairajan Issai;  Miller, Donald W.
浏览  |  Adobe PDF(3895Kb)  |  收藏  |  浏览/下载：223/55  |  提交时间：2019/12/20
blood-brain barrier (BBB)  drug delivery  transient modulation  HAV6 cadherin peptide  adenanthin  magnetic resonance imaging (MRI)  medulloblastoma  
Cognitive-enhancing effects of beta-sitosterol in vanadium-induced neurotoxicity in mice 期刊论文
JOURNAL OF NEUROCHEMISTRY, 2017, 卷号: 142, 页码: 238-238
作者:  Adebiyi,O.;  Olayemi,F.;  Olopade,J.;  Ning-Hua,T.
浏览  |  Adobe PDF(878Kb)  |  收藏  |  浏览/下载：168/76  |  提交时间：2017/10/23
Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drugresistance 期刊论文
Drug Resistance Updates, 2012, 卷号: 15, 期号: 0, 页码: 70–80
作者:  Suneet Shukla;  Zhe-Sheng Chen;  Suresh V. Ambudkar
Adobe PDF(762Kb)  |  收藏  |  浏览/下载：65/1  |  提交时间：2017/07/21
The protective role of 5-HMF against hypoxic injury 期刊论文
CELL STRESS & CHAPERONES, 2011, 卷号: 16, 期号: 3, 页码: 267-273
作者:  Li, Ming-Ming;  Wu, Li-Ying;  Zhao, Tong;  Xiong, Lei;  Huang, Xin;  Liu, Zhao-Hui;  Fan, Xue-Lai;  Xiao, Cheng-Rong;  Gao, Yue;  Ma, Yun-Bao;  Chen, Ji-Jun;  Zhu, Ling-Ling;  Fan, Ming
Adobe PDF(241Kb)  |  收藏  |  浏览/下载：378/94  |  提交时间：2012/04/10
5-hmf  Hypoxic Injury  Ecv304 Cells  Mmp  
HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress 期刊论文
Cancer Research, 2007, 卷号: 67, 期号: 22, 页码: 10920-10928
Peter Pyrko; Adel Kardosh; Weijun Wang; Wenyong Xiong; Axel H Schönthal; Thomas C Chen
浏览  |  Adobe PDF(578Kb)  |  收藏  |  浏览/下载：174/54  |  提交时间：2014/04/08