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High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载：73/11  |  提交时间：2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis 期刊论文
PHYTOMEDICINE, 2023, 卷号: 118, 页码: 154958
作者:  Guo,Rui;  Shang,Jian-Hua;  Ye,Rui-Han;  Zhao,Yun-Li;  Luo,Xiao-Dong
浏览  |  Adobe PDF(15381Kb)  |  收藏  |  浏览/下载：63/13  |  提交时间：2024/07/17
Alstonia scholaris  Indole alkaloids  Chronic glomerulonephritis  Network pharmacology  PI3K-AkT pathway  LEAVES  IDENTIFICATION  CONSTITUENTS  EXTRACT  MODELS  POTENT  
Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines 期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 3, 页码: 2977-2984
作者:  Wang, Hui-Li;  Liu, Yan-Chun;  Long, Ming-Peng;  Zheng, Chuan;  Yang, Jia-Hui
浏览  |  Adobe PDF(667Kb)  |  收藏  |  浏览/下载：226/60  |  提交时间：2019/11/07
receptor tyrosine kinase-like orphan receptor 1  lung adenocarcinoma  erlotinib resistance  AKT  mammalian target of rapamycin  small interfering RNA  
Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 673
作者:  Lu, Qin;  He, Yuanming;  Wang, Yuehu;  Gao, Li;  Zheng, Yunjing;  Zhang, Zubin;  Cao, Biyin;  Wang, Qi;  Mao, Xinliang;  Hu, Shaoyan
收藏  |  浏览/下载：253/0  |  提交时间：2018/07/30
Tspf  Rnf6/akt/mtor Signaling Pathway  Acute Myeloid Leukemia  Herbal Medicine  Saponins  Cell Apoptosis  Rnf6  
RACK1 is required for adipogenesis 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2016, 卷号: 311, 期号: 5, 页码: C831-C836
作者:  Kong, Qinghua;  Gao, Lan;  Niu, Yanfen;  Gongpan, Pianchou;  Xu, Yuhui;  Li, Yan;  Xiong, Wenyong
浏览  |  Adobe PDF(1017Kb)  |  收藏  |  浏览/下载：369/63  |  提交时间：2017/02/14
Rack1  3t3-l1  Adipogenesis  Wnt  Pi3k-akt-mtor-s6k  
The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signaling 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 9, 页码: 1208-1217
作者:  Su, Xing-li;  Su, Wen;  Wang, Ying;  Wang, Yue-hu;  Ming, Xin;  Kong, Yi
浏览  |  Adobe PDF(2212Kb)  |  收藏  |  浏览/下载：220/76  |  提交时间：2017/01/05
Psm2  Selaginellaceae  Pyrrolidinoindoline Alkaloid  Antiplatelet  Antithrombosis  Pi3k/akt Signaling  
Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling 期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2013, 卷号: 13, 期号: 7, 页码: 988-994
作者:  Beevers, Christopher S.;  Zhou, Hongyu;  Huang, Shile
浏览  |  Adobe PDF(230Kb)  |  收藏  |  浏览/下载：244/41  |  提交时间：2013/10/16
Curcumin  Mtor  Akt  Cancer  Cell Proliferation  Cell Death  
Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway 期刊论文
CELL DEATH & DISEASE, 2013, 卷号: 4, 页码: e804
作者:  Deng, Q.;  Yu, X.;  Xiao, L.;  Hu, Z.;  Luo, X.;  Tao, Y.;  Yang, L.;  Liu, X.;  Chen, H.;  Ding, Z.;  Feng, T.;  Tang, Y.;  Weng, X.;  Gao, J.;  Yi, W.;  Bode, A. M.;  Dong, Z.;  Liu, J.;  Cao, Y.
浏览  |  Adobe PDF(1755Kb)  |  收藏  |  浏览/下载：658/84  |  提交时间：2013/11/12
Neoalbaconol  Pdk1  Pi3-k/akt  Energy Depletion  Cancer Cell Death  
Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 卷号: 267, 期号: 1, 页码: 95-103
作者:  Fang, Xian-Ying;  Chen, Wei;  Fan, Jun-Ting;  Song, Ran;  Wang, Lu;  Gu, Yan-Hong;  Zeng, Guang-Zhi;  Shen, Yan;  Wu, Xue-Feng;  Tan, Ning-Hua;  Xu, Qiang;  Sun, Yang
浏览  |  Adobe PDF(1855Kb)  |  收藏  |  浏览/下载：796/140  |  提交时间：2013/03/18
Ra-v  Cyclopeptide  Mitochondrial Apoptosis Pathway  Pi3k/akt  Breast Cancer  
Overexpression and Small Molecule-Triggered Downregulation of CIP2A in Lung Cancer 期刊论文
PLOS ONE, 2011, 卷号: 6, 期号: 5, 页码: e20159
作者:  Ma, Liang;  Wen, Zhe-Sheng;  Liu, Zi;  Hu, Zheng;  Ma, Jun;  Chen, Xiao-Qin;  Liu, Yong-Qiang;  Pu, Jian-Xin;  Xiao, Wei-Lie;  Sun, Han-Dong;  Zhou, Guang-Biao
Adobe PDF(634Kb)  |  收藏  |  浏览/下载：393/127  |  提交时间：2012/03/16
Gastric-cancer  Breast-cancer  Phospho-akt  Smoking  Cells  Carcinoma  Survival  Leukemia  China