| Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling | |
| Beevers, Christopher S.1; Zhou, Hongyu2; Huang, Shile3,4 | |
| 通讯作者 | Beevers, CS (reprint author), Ross Univ, Dept Pharmacol, Sch Med, 630 US Hwy 1, North Brunswick, NJ 08902 USA. ; cbeevers@rossmed.edu.dm ; shuan1@lsuhsc.edu |
| 2013-09-01 | |
| 发表期刊 | ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
 |
| ISSN | 1871-5206 |
| 卷号 | 13期号:7页码:988-994 |
| 摘要 | The polyphenol natural product curcumin possesses a plethora of biological and pharmacological properties. For years, much interest has been placed in the development and use of curcumin and its derivatives for the prevention and treatment of cardiovascular, diabetic, and neurodegenerative diseases, as well as cancer. Increasing evidence suggests that curcumin displays amazing molecular versatility, and the number of its proposed cellular targets grows as the research continues. The mammalian target of rapamycin ( mTOR) is a master kinase, regulating cell growth/proliferation, survival, and motility. Dysregulated mTOR signaling occurs frequently in cancer, and targeting mTOR signaling is a promising strategy for cancer therapy. Recent studies have identified mTOR as a novel target of curcumin. Here we focus on reviewing current knowledge regarding the effects of curcumin on mTOR signaling for better understanding the anticancer mechanism of curcumin. The emerging studies of mTOR signaling and clinical studies on curcumin with cancer patients are also discussed here. |
| 关键词 | Curcumin Mtor Akt Cancer Cell Proliferation Cell Death |
| 学科领域 | Oncology ; Chemistry, Medicinal |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324249500004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16665 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Ross Univ, Dept Pharmacol, Sch Med, Picard Portsmouth, Commonwealth Of, W Ind Assoc St 2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan Province, Peoples R China 3.Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71105 USA 4.Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA |
| 推荐引用方式 GB/T 7714 | Beevers, Christopher S.,Zhou, Hongyu,Huang, Shile. Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2013,13(7):988-994. |
| APA | Beevers, Christopher S.,Zhou, Hongyu,&Huang, Shile.(2013).Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,13(7),988-994. |
| MLA | Beevers, Christopher S.,et al."Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling".ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 13.7(2013):988-994. |
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| 2013AC-AMC-Curcumin.（230KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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