Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling
Beevers, Christopher S.1; Zhou, Hongyu2; Huang, Shile3,4
Corresponding AuthorBeevers, CS (reprint author), Ross Univ, Dept Pharmacol, Sch Med, 630 US Hwy 1, North Brunswick, NJ 08902 USA. ; cbeevers@rossmed.edu.dm ; shuan1@lsuhsc.edu
AbstractThe polyphenol natural product curcumin possesses a plethora of biological and pharmacological properties. For years, much interest has been placed in the development and use of curcumin and its derivatives for the prevention and treatment of cardiovascular, diabetic, and neurodegenerative diseases, as well as cancer. Increasing evidence suggests that curcumin displays amazing molecular versatility, and the number of its proposed cellular targets grows as the research continues. The mammalian target of rapamycin ( mTOR) is a master kinase, regulating cell growth/proliferation, survival, and motility. Dysregulated mTOR signaling occurs frequently in cancer, and targeting mTOR signaling is a promising strategy for cancer therapy. Recent studies have identified mTOR as a novel target of curcumin. Here we focus on reviewing current knowledge regarding the effects of curcumin on mTOR signaling for better understanding the anticancer mechanism of curcumin. The emerging studies of mTOR signaling and clinical studies on curcumin with cancer patients are also discussed here.
KeywordCurcumin Mtor Akt Cancer Cell Proliferation Cell Death
Subject AreaOncology ; Chemistry, Medicinal
Indexed BySCI
WOS Research AreaOncology ; Pharmacology & Pharmacy
WOS SubjectOncology ; Chemistry, Medicinal
WOS IDWOS:000324249500004
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Ross Univ, Dept Pharmacol, Sch Med, Picard Portsmouth, Commonwealth Of, W Ind Assoc St
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan Province, Peoples R China
3.Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71105 USA
4.Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA
Recommended Citation
GB/T 7714
Beevers, Christopher S.,Zhou, Hongyu,Huang, Shile. Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2013,13(7):988-994.
APA Beevers, Christopher S.,Zhou, Hongyu,&Huang, Shile.(2013).Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,13(7),988-994.
MLA Beevers, Christopher S.,et al."Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling".ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 13.7(2013):988-994.
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