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题名: Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling
作者: Beevers, Christopher S.1; Zhou, Hongyu2; Huang, Shile3, 4
刊名: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
关键词: Curcumin ; mTOR ; Akt ; Cancer ; Cell proliferation ; Cell death
英文摘要: The polyphenol natural product curcumin possesses a plethora of biological and pharmacological properties. For years, much interest has been placed in the development and use of curcumin and its derivatives for the prevention and treatment of cardiovascular, diabetic, and neurodegenerative diseases, as well as cancer. Increasing evidence suggests that curcumin displays amazing molecular versatility, and the number of its proposed cellular targets grows as the research continues. The mammalian target of rapamycin ( mTOR) is a master kinase, regulating cell growth/proliferation, survival, and motility. Dysregulated mTOR signaling occurs frequently in cancer, and targeting mTOR signaling is a promising strategy for cancer therapy. Recent studies have identified mTOR as a novel target of curcumin. Here we focus on reviewing current knowledge regarding the effects of curcumin on mTOR signaling for better understanding the anticancer mechanism of curcumin. The emerging studies of mTOR signaling and clinical studies on curcumin with cancer patients are also discussed here.
出版日期: 2013-09-01
卷号: 13, 期号:7, 页码:988-994
语种: 英语
收录类别: SCI
学科分类: Oncology; Chemistry, Medicinal
ISSN号: 1871-5206
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16665
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Ross Univ, Dept Pharmacol, Sch Med, Picard Portsmouth, Commonwealth Of, W Ind Assoc St
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan Province, Peoples R China
3.Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71105 USA
4.Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71105 USA

Recommended Citation:
Beevers, Christopher S.; Zhou, Hongyu; Huang, Shile.Hitting the Golden TORget: Curcumin's Effects on mTOR Signaling,ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2013,13(7):988-994
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