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Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文
NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411
作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying;  Shen, Yu;  Zhao, Qin-Shi;  Leng, Ying
浏览  |  Adobe PDF(6451Kb)  |  收藏  |  浏览/下载：28/9  |  提交时间：2024/04/30
Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36  
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
浏览  |  Adobe PDF(3047Kb)  |  收藏  |  浏览/下载：320/39  |  提交时间：2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Efficient synthesis of new phenanthridine Wnt/beta-catenin signaling pathway agonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 1491-1499
作者:  Chen, Duozhi;  Zhang, Heng;  Jing, Chenxu;  He, Xiaoli;  Yang, Bijuan;  Cai, Jieyun;  Zhou, Yunfu;  Song, Xiaoming;  Li, Lin;  Hao, Xiaojiang
收藏  |  浏览/下载：369/0  |  提交时间：2018/11/12
Wnt/beta-catenin signaling agonist  Phenanthridine derivatives  Structural optimization  
The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 977-989
作者:  Yi, Shou-pu;  Kong, Qing-hong;  Li, Yu-lei;  Pan, Chen-ling;  Yu, Jie;  Cui, Ben-qiang;  Wang, Ying-fei;  Wang, Guan-lin;  Zhou, Pei-lan;  Wang, Li-li;  Gong, Ze-hui;  Su, Rui-bin;  Shen, Yue-hai;  Yu, Gang;  Chang, Kwen-jen
浏览  |  Adobe PDF(854Kb)  |  收藏  |  浏览/下载：350/70  |  提交时间：2017/08/29
Opioid Receptor  Mixed Agonist  Dpi-125  Analgesia  Respiratory Depression  Addiction  
Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice 期刊论文
DIABETOLOGIA, 2016, 卷号: 59, 期号: 6, 页码: 1276-1286
作者:  Feng, Li;  Luo, Huan;  Xu, Zhijian;  Yang, Zhuo;  Du, Guoxin;  Zhang, Yu;  Yu, Lijing;  Hu, Kaifeng;  Zhu, Weiliang;  Tong, Qingchun;  Chen, Kaixian;  Guo, Fujiang;  Huang, Cheng;  Li, Yiming
浏览  |  Adobe PDF(841Kb)  |  收藏  |  浏览/下载：243/97  |  提交时间：2016/08/22
Alternative Binding Site  Bavachinin  Canonical Ligand-binding Pocket  Carbohydrate Metabolism  Lipid Metabolism  Pan-ppar Agonist  Synergistic Effects  
Microfractionation bioactivity-based ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry for the identification of nuclear factor-kappa B inhibitors and beta(2) adrenergic receptor agonists in an alkaloidal extract of the folk herb Alstonia scholaris 期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2012, 卷号: 908, 页码: 98-104
作者:  Hou, Yuanyuan;  Cao, Xuelin;  Wang, Liqiang;  Cheng, Binfeng;  Dong, Linyi;  Luo, Xiaodong;  Bai, Gang;  Gao, Wenyuan
Adobe PDF(764Kb)  |  收藏  |  浏览/下载：312/89  |  提交时间：2013/01/22
Dual-bioactivity-integrated Fingerprinting  Constituent Identification  Nuclear Factor-kappa b Inhibitor  Beta(2) Adrenergic Receptor Agonist  Ultra Performance Liquid Chromatography/quadrupole Time-of-flight Mass Spectrometry  
Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for beta(2)AR agonist identification in alkaloidal extract of Alstonia scholaris 期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2012, 卷号: 1227, 页码: 203-209
作者:  Hou, Yuanyuan;  Cao, Xuelin;  Dong, Linyi;  Wang, Liqiang;  Cheng, Binfeng;  Shi, Qian;  Luo, Xiaodong;  Bai, Gang
Adobe PDF(949Kb)  |  收藏  |  浏览/下载：538/191  |  提交时间：2012/06/07
Bioactivity-integrated Fingerprinting  Constituent Identification  Beta(2) Adrenergic Receptor Agonist  Lcms-it-tof