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Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2023, 卷号: 41, 期号: 19, 页码: 2453-2468
作者:  Dong,Wei;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Feng-Jiao;  Li,Tian-Ze;  Wang,Yong-Cui;  He,Xiao-Feng;  Geng,Chang-An;  Zhang,Xue-Mei;  Chen,Ji-Jun
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Artemzhongdianolides B1-B17  Artemisia zhongdianensis  Guaiane-type sesquiterpenoid dimers  Antihepatoma activity  p38MAPK pathway  Cancer  NMR spectroscopy  X-ray diffraction  ARREST  CELLS  JNK  
Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca2+/CaMKII and PKA Pathways and Multiple-Enzyme Inhibition 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 卷号: 71, 期号: 43, 页码: 16148-16159
作者:  Cui,Can;  Wu,Sheng-Li;  Chen,Ji-Jun;  Gongpan,Pianchou;  Guan,Min;  Geng,Chang-An
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Alpinia oxyphylla  sesquiterpenoids  GLP-1 stimulation  Ca2+/CaMKII and PKA pathways  alpha-glucosidase and PTP1B inhibitory activity  
Design, synthesis, and biological evaluation of artemyrianolide H derivatives as potential antihepatoma agents 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 137, 页码: 106617
作者:  Li,Tian-Ze;  Yang,Xiao-Tong;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Feng-Jiao;  Wang,Yong-Cui;  Chen,Ji-Jun
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Artemyrianolide H  Germacranolide derivatives  Antihepatoma activity  Apoptosis  DIMERS  
Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum 期刊论文
JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2023, 卷号: 65, 期号: 10, 页码: 2320-2335
作者:  Zhao,Dake;  Zhang,Ya;  Ren,Huanxing;  Shi,Yana;  Dong,Ding;  Li,Zonghang;  Cui,Guanghong;  Shen,Yong;  Mou,Zongmin;  Kennelly,Edward J.;  Huang,Luqi;  Ruan,Jue;  Chen,Suiyun;  Yu,Diqiu;  Cun,Yupeng
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Aconitum vilmorinianum  acute toxicity  biosynthetic pathway  diterpenoid alkaloid  evolutionary origin  genome assembly  PHYLOGENETIC ANALYSIS  SUPPLEMENT TREMBL  CANDIDATE GENES  R PACKAGE  TOOL  TRANSCRIPTOME  IDENTIFICATION  RANUNCULACEAE  PREDICTION  DIVERSITY  
Five new limonoids isolated from Walsura robusta. 期刊论文
Natural products and bioprospecting, 2023, 卷号: 13, 期号: 1, 页码: 7-7
作者:  Hou, Li;  Mei, Cui-Xuan;  Yuan, Chun-Mao;  Tang, Gui-Hua;  Chen, Duo-Zhi;  Zhao, Qing;  He, Hong-Ping;  Cao, Ming-Ming;  Hao, Xiao-Jiang
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Global consortium for the classification of fungi and fungus-like taxa 期刊论文
MYCOSPHERE, 2023, 卷号: 14, 期号: 1, 页码: 1960-2012
作者:  Hyde,K. D.;  Abdel-Wahab,M. A.;  Abdollahzadeh,J.;  Abeywickrama,P. D.;  Absalan,S.;  Afshari,N.;  Ainsworth,A. M.;  Akulov,O. Y.;  Aleoshin,V. V.;  Al-Sadi,A. M.;  Alvarado,P.;  Alves,A.;  Alves-Silva,G.;  Amalfi,M.;  Amira,Y.;  Amuhenage,T. B.;  Anderson,J. L.;  Antonin,V;  Aouali,S.;  Aptroot,A.;  Apurillo,C. C. S.;  Araujo,J. P. M.;  Ariyawansa,H. A.;  Armand,A.;  Arumugam,E.;  Asghari,R.;  Assis,D. M. A.;  Atienza,V;  Avasthi,S.;  Azevedo,E.;  Bahkali,A. H.;  Bakhshi,M.;  Banihashemi,Z.;  Bao,D. F.;  Baral,H. O.;  Barata,M.;  Barbosa,F. R.;  Barbosa,R. N.;  Barreto,R. W.;  Baschien,C.;  Belamesiatseva,D. B.;  Bennett Reuel,M.;  Bera,I;  Bezerra,J. D. P.;  Bezerra,J. L.;  Bhat,D. J.;  Bhunjun,C. S.;  Bianchinotti,M.,V;  Blaszkowski,J.;  Blondelle,A.;  Boekhout,T.;  Bonito,G.;  Boonmee,S.;  Boonyuen,N.;  Bregant,C.;  Buchanan,P.;  Bundhun,D.;  Burgaud,G.;  Burgess,T.;  Buyck,B.;  Cabarroi-Hernandez,M.;  Caceres,M. E. S.;  Caeiro,M. F.;  Cai,L.;  Cai,M. F.;  Calabon,M. S.;  Calaca,F. J. S.;  Callalli,M.;  Camara,M. P. S.;  Cano-Lira,J. F.;  Cantillo,T.;  Cao,B.;  Carlavilla,J. R.;  Carvalho,A.;  Castaneda-Ruiz,R. F.;  Castlebury,L.;  Castro-Jauregui,O.;  Catania,M. D.,V;  Cavalcanti,L. H.;  Cazabonne,J.;  Cedeno-Sanchez,M. L.;  Chaharmiri-Dokhaharani,S.;  Chaiwan,N.;  Chakraborty,N.;  Chaverri,P.;  Cheewangkoon,R.;  Chen,C.;  Chen,C. Y.;  Chen,K. H.;  Chen,J.;  Chen,Q.;  Chen,W. H.;  Chen,Y. P.;  Chethana,K. W. T.;  Coleine,C.;  Conde,T. O.;  Corazon-Guivin,M. A.;  Cortes-Perez,A.;  Costa-Rezende,D. H.;  Courtecuisse,R.;  Crouch,J. A.;  Crous,P. W.;  Cui,B. K.;  Cui,Y. Y.;  da Silva,D. K. A.;  da Silva,G. A.;  da Silva,I. R.;  da Silva,R. M. F.;  da Silva Santos,A. C.;  Dai,D. Q.;  Dai,Y. C.;  Damm,U.;  Darmostuk,V;  Zoha,Daroodi;  Das,K.;  Das,K.;  Davoodian,N.;  Davydov,E. A.;  Dayarathne,M. C.;  Decock,C.;  de Groot,M. D.;  De Kesel,A.;  dela Cruz,T. E. E.;  De Lange,R.;  Delgado,G.;  Denchev,C. M.;  Denchev,T. T.;  de Oliveira,N. T.;  de Silva,N.,I;  de Souza,F. A.;  Dentinger,B.;  Devadatha,B.;  Dianese,J. C.;  Dima,B.;  Diniz,A. G.;  Dissanayake,A. J.;  Dissanayake,L. S.;  Dogan,H. H.;  Doilom,M.;  Dolatabadi,S.;  Dong,W.;  Dong,Z. Y.;  Dos Santos,L. A.;  Drechsler-Santos,E. R.;  Du,T. Y.;  Dubey,M. K.;  Dutta,A. K.;  Egidi,E.;  Elliott,T. F.;  Elshahed,M. S.;  Erdogdu,M.;  Ertz,D.;  Etayo,J.;  Evans,H. C.;  Fan,X. L.;  Fan,Y. G.;  Fedosova,A. G.;  Fell,J.;  Fernandes,I;  Firmino,A. L.;  Fiuza,P. O.;  Flakus,A.;  Fragoso de Souza,C. A.;  Frisvad,J. C.;  Fryar,S. C.;  Gabaldon,T.;  Gajanayake,A. J.;  Galindo,L. J.;  Gannibal,P. B.;  Garcia,D.;  Garcia-Sandoval,S. R.;  Garrido-Benavent,I;  Garzoli,L.;  Gautam,A. K.;  Ge,Z-W;  Gene,D. J.;  Gentekaki,E.;  Ghobad-Nejhad,M.;  Giachini,A. J.;  Gibertoni,T. B.;  Goes-Neto,A.;  Gomdola,D.;  Gomes de Farias,A. R.;  Gorjon,S. P.;  Goto,B. T.;  Granados-Montero,M. M.;  Griffith,G. W.;  Groenewald,J. Z.;  Groenewald,M.;  Grossart,H. P.;  Gueidan,C.;  Gunarathne,A.;  Gunaseelan,S.;  Gusmao,L. F. P.;  Gutierrez,A. C.;  Guzman-Davalos,L.;  Haelewaters,D.;  Halling,R.;  Han,Y. F.;  Hapuarachchi,K. K.;  Harder,C. B.;  Harrington,T. C.;  Hattori,T.;  He,M. Q.;  He,S.;  He,S. H.;  Healy,R.;  Herandez-Restrepo,M.;  Heredia,G.;  Hodge,K. T.;  Holgado-Rojas,M.;  Hongsanan,S.;  Horak,E.;  Hosoya,T.;  Houbraken,J.;  Huang,S. K.;  Huanraluek,N.;  Hur,J. S.;  Hurdeal,V. G.;  Hustad,V. P.;  Iotti,M.;  Iturriaga,T.;  Jafar,E.;  Janik,P.;  Jany,J. L.;  Jayalal,R. G. U.;  Jayasiri,S. C.;  Jayawardena,R. S.;  Jeewon,R.;  Jeronimo,G. H.;  Jesus,A. L.;  Jin,J.;  Johnston,P. R.;  Jones,E. B. G.;  Joshi,Y.;  Justo,A.;  Kaishian,P.;  Kakishima,M.;  Kaliyaperumal,M.;  Kang,G. P.;  Kang,J. C.;  Karakehian,J. M.;  Karimi,O.;  Karpov,S. A.;  Karunarathna,S. C.;  Kaufmann,M.;  Kemler,M.;  Kezo,K.;  Khyaju,S.;  Kirchmair,M.;  Kirk,P. M.;  Kitaura,M. J.;  Klawonn,I;  Kolarik,M.;  Kong,A.;  Kuhar,F.;  Kukwa,M.;  Kumar,S.;  Kusan,I;  Lado,C.;  Larsson,K. H.;  Latha,K. P. D.;  Lee,H. B.;  Leonardi,M.;  Leontyev,D. L.;  Lestari,A. S.;  Li,C. J. Y.;  Li,D. W.;  Li,H.;  Li,H. Y.;  Li,L.;  Li,Q. R.;  Li,Q.;  Li,W. L.;  Li,Y.;  Li,Y. C.;  Li,Y. X.;  Liao,C. F.;  Liimatainen,K.;  Lim,Y. W.;  Lin,C. G.;  Linaldeddu,B. T.;  Linde,C. C.;  Linn,M. M.;  Liu,F.;  Liu,J. K.;  Liu,N. G.;  Liu,S.;  Liu,S. L.;  Liu,X. F.;  Liu,X. Y.;  Liu,X. Z.;  Liu,Z. B.;  Lu,L.;  Lu,Y. Z.;  Luangharn,T.;  Luangsa-ard,J. J.;  Lumbsch,H. T.;  Lumyong,S.;  Luo,L.;  Luo,M.;  Luo,Z. L.;  Ma,J.;  Machado,A. R.;  Madagammana,A. D.;  Madrid,H.;  Magurno,F.;  Magyar,D.;  Mahadevan,N.;  Maharachchikumbura,S. S. N.;  Maimaiti,Y.;  Malosso,E.;  Manamgoda,D. S.;  Manawasinghe,I. S.;  Mapook,A.;  Marasinghe,D. S.;  Mardones,M.;  Marin-Felix,Y.;  Marquez,R.;  Masigol,H.;  Matocec,N.;  May,T. W.;  McKenzie,E. H. C.;  Meiras-Ottoni,A.;  Melo,R. F. R.;  Mendes-Alvarenga,R. L.;  Mendieta,S.;  Meng,Q. F.;  Menkis,A.;  Menolli,N.,Jr.;  Mesic,A.;  Meza Calvo,J. G.;  Mikhailov,K.,V;  Miller,S. L.;  Moncada,B.;  Moncalvo,J. M.;  Monteiro,J. S.;  Monteiro,M.;  Mora-Montes,H. M.;  Moreau,P. A.;  Mueller,G. M.;  Mukhopadyay,S.;  Murugadoss,R.;  Nagy,L. G.;  Najafiniya,M.;  Nanayakkara,C. M.;  Nascimento,C. C.;  Nei,Y.;  Neves,M. A.;  Neuhauser,S.;  Niego,A. G. T.;  Nilsson,R. H.;  Niskanen,T.;  Niveiro,N.;  Noorabadi,M. T.;  Noordeloos,M. E.;  Norphanphoun,C.;  Nunez Otano,N. B.;  O'Donnell,R. P.;  Oehl,F.;  Olariaga,I;  Orlando,O. P.;  Pang,K. L.;  Papp,V;  Pawlowska,J.;  Peintner,U.;  Pem,D.;  Pereira,O. L.;  Perera,R. H.;  Perez-Moreno,J.;  Perez-Ortega,S.;  Peter,G.;  Phillips,A. J. L.;  Phonemany,M.;  Phukhamsakda,C.;  Phutthacharoen,K.;  Piepenbring,M.;  Pires-Zottarelli,C. L. A.;  Poinar,G.;  Posta,A.;  Prieto,M.;  Promputtha,I;  Quandt,C. A.;  Radek,R.;  Rahnama,K.;  Raj,K. N. A.;  Rajeshkumar,K. C.;  Rama,T.;  Rambold,G.;  Ramirez-Cruz,V;  Rasconi,S.;  Rathnayaka,A. R.;  Raza,M.;  Ren,G. C.;  Robledo,G. L.;  Rodriguez-Flakus,P.;  Ronikier,A.;  Rossi,W.;  Ryberg,M.;  Ryvarden,L. R.;  Salvador-Montoya,C. A.;  Samant,B.;  Samarakoon,B. C.;  Samarakoon,M. C.;  Sanchez-Castro,I;  Sanchez-Garcia,M.;  Sandoval-Denis,M.;  Santamaria,B.;  Santiago,A. L. C. M. A.;  Sarma,V. V.;  Savchenko,A.;  Savchenko,K.;  Saxena,R. K.;  Scholler,M.;  Schoutteten,N.;  Seifollahi,E.;  Selbmann,L.;  Selcuk,F.;  Senanayake,I. C.;  Seto,K.;  Shabashova,T. G.;  Shen,H. W.;  Shen,Y. M.;  Silva-Filho,A. G. S.;  Simmons,D. R.;  Singh,R.;  Sir,E. B.;  Song,C. G.;  Souza-Motta,C. M.;  Sruthi,O. P.;  Stadler,M.;  Stchigel,A. M.;  Stemler,J.;  Stephenson,S. L.;  Strassert,J. F. H.;  Su,H. L.;  Su,L.;  Suetrong,S.;  Sulistyo,B.;  Sun,Y. F.;  Sun,Y. R.;  Svantesson,S.;  Sysouphanthong,P.;  Takamatsu,S.;  Tan,T. H.;  Tanaka,K.;  Tang,A. M. C.;  Tang,X.;  Tanney,J. B.;  Tavakol,N. M.;  Taylor,J. E.;  Taylor,P. W. J.;  Tedersoo,L.;  Tennakoon,D. S.;  Thamodini,G. K.;  Thines,M.;  Thiyagaraja,V;  Thongklang,N.;  Tiago,P.,V;  Tian,Q.;  Tian,W. H.;  Tibell,L.;  Tibell,S.;  Tibpromma,S.;  Tkalcec,Z.;  Tomsovsky,M.;  Toome-Heller,M.;  Torruella,G.;  Tsurykau,A.;  Udayanga,D.;  Ulukapi,M.;  Untereiner,W. A.;  Uzunov,B. A.;  Valle,L. G.;  Van Caenegem,W.;  Van den Wyngaert,S.;  Van Vooren,N.;  Velez,P.;  Verma,R. K.;  Vieira,L. C.;  Vieira,W. A. S.;  Vizzini,A.;  Walker,A.;  Walker,A. K.;  Wanasinghe,D. N.;  Wang,C. G.;  Wang,K.;  Wang,S. X.;  Wang,X. Y.;  Wang,Y.;  Wannasawang,N.;  Wartchow,F.;  Wei,D. P.;  Wei,X. L.;  White,J. F.;  Wijayawardene,N. N.;  Wijesinghe,S. N.;  Wijesundara,D. S. A.;  Wisitrassameewong,K.;  Worthy,F. R.;  Wu,F.;  Wu,G.;  Wu,H. X.;  Wu,N.;  Wu,W. P.;  Wurzbacher,C.;  Xiao,Y. P.;  Xiong,Y. R.;  Xu,B.;  Xu,L. J.;  Xu,R.;  Xu,R. F.;  Xu,R. J.;  Xu,T. M.;  Yakovchenko,L.;  Yan,J. Y.;  Yang,H. D.;  Yang,J.;  Yang,Z. L.;  Yang,Y. H.;  Yapa,N.;  Yasanthika,E.;  Youssef,N. H.;  Yu,F. M.;  Yu,Q.;  Yu,X. D.;  Yu,Y. X.;  Yu,Z. F.;  Yuan,H. S.;  Yuan,Y.;  Yurkov,A.;  Zafari,D.;  Zamora,J. C.;  Zare,R.;  Zeng,M.;  Zeng,N. K.;  Zeng,X. Y.;  Zhang,F.;  Zhang,H.;  Zhang,J. F.;  Zhang,J. Y.;  Zhang,Q. Y.;  Zhang,S. N.;  Zhang,W.;  Zhang,Y.;  Zhang,Y. X.;  Zhao,C. L.;  Zhao,H.;  Zhao,Q.;  Zhao,R. L.;  Zhou,L. W.;  Zhou,M.;  Zhurbenko,M. P.;  Zin,H. H.;  Zucconi,L.
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classification  nomenclature  scientific criticism  taxonomy  LEVEL PHYLOGENETIC CLASSIFICATION  INCORPORATING ANAMORPHIC FUNGI  FATTY-ACID-COMPOSITION  DNA-SEQUENCE DATA  NATURAL CLASSIFICATION  LEAF-LITTER  SPECIES RECOGNITION  IDENTIFICATION  NOMENCLATURE  TREE  
Association of sirtuins (SIRT1-7) with lung and intestinal diseases 期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2022, 卷号: 477, 期号: 11, 页码: 2539-2552
作者:  Chen, Yuhan;  Zhou, Di;  Feng, Yuan;  Li, Bingxin;  Cui, Yong;  Chen, Gang;  Li, Ning
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Sirtuins  Lung-intestinal axis  Inflammation  Tumors  MicroRNAs  ENDOPLASMIC-RETICULUM STRESS  EPITHELIAL-MESENCHYMAL TRANSITION  CANCER CELLS  ULCERATIVE-COLITIS  COLORECTAL-CANCER  DOWN-REGULATION  PROLIFERATION  SUPPRESSES  ACTIVATION  APOPTOSIS  
Two new species of Amanita section Amanita from Central China 期刊论文
MYCOLOGICAL PROGRESS, 2022, 卷号: 21, 期号: 9, 页码: 78
作者:  Su, Yu-Ting;  Cai, Qing;  Qin, Wei-Qiang;  Cui, Yang-Yang;  Chen, Zuo-Hong;  Yang, Zhu L.
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FungalTraits: a user friendly traits database of fungi and fungus-like stramenopiles (vol 105, 116, 2020) 期刊论文
FUNGAL DIVERSITY, 2021, 卷号: 107, 期号: 1, 页码: 129-132
作者:  Polme,Sergei;  Abarenkov,Kessy;  Henrik Nilsson,R.;  Lindahl,Bjorn D.;  Clemmensen,Karina Engelbrecht;  Kauserud,Havard;  Nguyen,Nhu;  Kjoller,Rasmus;  Bates,Scott T.;  Baldrian,Petr;  Froslev,Tobias Guldberg;  Adojaan,Kristjan;  Vizzini,Alfredo;  Suija,Ave;  Pfister,Donald;  Baral,Hans-Otto;  Jarv,Helle;  Madrid,Hugo;  Norden,Jenni;  Liu,Jian-Kui;  Pawlowska,Julia;  Poldmaa,Kadri;  Partel,Kadri;  Runnel,Kadri;  Hansen,Karen;  Larsson,Karl-Henrik;  Hyde,Kevin David;  Sandoval-Denis,Marcelo;  Smith,Matthew E.;  Toome-Heller,Merje;  Wijayawardene,Nalin N.;  Menolli,Nelson,Jr.;  Reynolds,Nicole K.;  Drenkhan,Rein;  Maharachchikumbura,Sajeewa S. N.;  Gibertoni,Tatiana B.;  Laessoe,Thomas;  Davis,William;  Tokarev,Yuri;  Corrales,Adriana;  Soares,Adriene Mayra;  Agan,Ahto;  Machado,Alexandre Reis;  Arguelles-Moyao,Andres;  Detheridge,Andrew;  de Meiras-Ottoni,Angelina;  Verbeken,Annemieke;  Dutta,Arun Kumar;  Cui,Bao-Kai;  Pradeep,C. K.;  Marin,Cesar;  Stanton,Daniel;  Gohar,Daniyal;  Wanasinghe,Dhanushka N.;  Otsing,Eveli;  Aslani,Farzad;  Griffith,Gareth W.;  Lumbsch,Thorsten H.;  Grossart,Hans-Peter;  Masigol,Hossein;  Timling,Ina;  Hiiesalu,Inga;  Oja,Jane;  Kupagme,John Y.;  Geml,Jozsef;  Alvarez-Manjarrez,Julieta;  Ilves,Kai;  Loit,Kaire;  Adamson,Kalev;  Nara,Kazuhide;  Kungas,Kati;  Rojas-Jimenez,Keilor;  Bitenieks,Kriss;  Irinyi,Laszlo;  Nagy,Laszlo G.;  Soonvald,Liina;  Zhou,Li-Wei;  Wagner,Lysett;  Aime,M. Catherine;  Opik,Maarja;  Mujica,Maria Isabel;  Metsoja,Martin;  Ryberg,Martin;  Vasar,Martti;  Murata,Masao;  Nelsen,Matthew P.;  Cleary,Michelle;  Samarakoon,Milan C.;  Doilom,Mingkwan;  Bahram,Mohammad;  Hagh-Doust,Niloufar;  Dulya,Olesya;  Johnston,Peter;  Kohout,Petr;  Chen,Qian;  Tian,Qing;  Nandi,Rajasree;  Amiri,Rasekh;  Perera,Rekhani Hansika;  dos Santos Chikowski,Renata;  Mendes-Alvarenga,Renato L.;  Garibay-Orijel,Roberto;  Gielen,Robin;  Phookamsak,Rungtiwa;  Jayawardena,Ruvishika S.;  Rahimlou,Saleh;  Karunarathna,Samantha C.;  Tibpromma,Saowaluck;  Brown,Shawn P.;  Sepp,Siim-Kaarel;  Mundra,Sunil;  Luo,Zhu-Hua;  Bose,Tanay;  Vahter,Tanel;  Netherway,Tarquin;  Yang,Teng;  May,Tom;  Varga,Torda;  Li,Wei;  Coimbra,Victor Rafael Matos;  de Oliveira,Virton Rodrigo Targino;  de Lima,Vitor Xavier;  Mikryukov,Vladimir S.;  Lu,Yongzhong;  Matsuda,Yosuke;  Miyamoto,Yumiko;  Koljalg,Urmas;  Tedersoo,Leho
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Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis 期刊论文
CARBOHYDRATE POLYMERS, 2021, 卷号: 269, 页码: 118290
作者:  Li,Shanni;  Zhong,Wei;  Pan,Ying;  Lin,Lisha;  Cai,Ying;  Mao,Hui;  Zhang,Taocui;  Li,Sujuan;  Chen,Ru;  Zhou,Lutan;  Wang,Weili;  Cui,Qinghua;  Yin,Ronghua;  Huang,Shengxiong;  Zhao,Jinhua
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Disaccharide branch  Fucosylated glycosaminoglycan  Holothuria nobilis  Oligosaccharide  Anticoagulant  INTRINSIC TENASE COMPLEX  CHONDROITIN SULFATE  ACAUDINA-MOLPADIOIDEA  FACTOR XASE  HEPARIN  DEPOLYMERIZATION  OLIGOSACCHARIDES  POLYSACCHARIDES  DERIVATIVES