Association of sirtuins (SIRT1-7) with lung and intestinal diseases

doi:10.1007/s11010-022-04462-9

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	Association of sirtuins (SIRT1-7) with lung and intestinal diseases
	Chen, Yuhan; Zhou, Di; Feng, Yuan; Li, Bingxin; Cui, Yong; Chen, Gang; Li, Ning
	2022
发表期刊	MOLECULAR AND CELLULAR BIOCHEMISTRY
卷号	477 期号:11 页码:2539-2552
摘要	Exterior-interior correlation between the lung and large intestine is one of the important contents of traditional Chinese medicine. This theory describes the role of the lung and the intestine in association with disease treatment. The lung-gut axis is a modern extension of the exterior-interior correlation between lung and large intestine theory in TCM. Sirtuin (SIRT) is a nicotinamide adenine dinucleotide (NAD(+))-dependent enzyme family with deacetylase properties, which is highly conserved from bacteria to humans. The sirtuin defines seven silencing regulatory proteins (SIRT1-7) in human cells. It can regulate aging, metabolism, and certain diseases. Current studies have shown that sirtuins have dual characteristics, acting as both tumor promoters and tumor inhibitors in cancers. This paper provides a comparative summary of the roles of SIRT1-7 in the intestine and lung (both inflammatory diseases and tumors), and the promoter/suppressor effects of targeting SIRT family microRNAs and modulators of inflammation or tumors. Sirtuins have great potential as drug targets for the treatment of intestinal and respiratory diseases. Meanwhile, it may provide new ideas of future drug target research.
关键词	Sirtuins Lung-intestinal axis Inflammation Tumors MicroRNAs ENDOPLASMIC-RETICULUM STRESS EPITHELIAL-MESENCHYMAL TRANSITION CANCER CELLS ULCERATIVE-COLITIS COLORECTAL-CANCER DOWN-REGULATION PROLIFERATION SUPPRESSES ACTIVATION APOPTOSIS
DOI	10.1007/s11010-022-04462-9
收录类别	SCI
WOS记录号	WOS:000799534400001
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74782
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen, Yuhan,Zhou, Di,Feng, Yuan,et al. Association of sirtuins (SIRT1-7) with lung and intestinal diseases[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2022,477(11):2539-2552.
APA	Chen, Yuhan.,Zhou, Di.,Feng, Yuan.,Li, Bingxin.,Cui, Yong.,...&Li, Ning.(2022).Association of sirtuins (SIRT1-7) with lung and intestinal diseases.MOLECULAR AND CELLULAR BIOCHEMISTRY,477(11),2539-2552.
MLA	Chen, Yuhan,et al."Association of sirtuins (SIRT1-7) with lung and intestinal diseases".MOLECULAR AND CELLULAR BIOCHEMISTRY 477.11(2022):2539-2552.

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