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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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GST,p < 0.001) and low levels of seed-based gene flow. C. debaoensis (Cycadaceae) is an endangered species restricted to the border of Guangxi and Yunnan province in southwest China. This species has been classified into two types: sand and karst, according to the soil matrix they grow on. We examined chloroplast sequence variation of the cpDNA sequences from 11 populations of this species. Significant population genetic differentiation was detected (GST= 0.684 and FST = 0.74160). There was marked genetic differentiation between populations in the sand and karst regions and no expansion was detected. Climate changes during glacial periods have had significant effects on the current distribution of cycads. The molecular phylogenetic data, together with the geographic distribution of the haplotypes, suggest that C. debaoensis experienced range contraction during glacial periods, and that the current populations are still confined to the original refugia in southwest China which have favorable habitats in glacial period. These results imply that small refugia were maintained in both sand and karst regions during the LGM (last glacial maximum). This species had no postglacial recolonization and only stayed in these refugia up to now. The low within-population diversity of C. debaoensis suggests that there were strong bottleneck events or founder effects within each separate region during the Quaternary climatic oscillations. Relatively high genetic and haplotype diversities were detected in the newly discovered populations, which located at intermediate locality of sand regions and had morphological variation; this is probably the consequence of the admixture of different haplotypes colonizing the area from separate sources. C. micholitzii occurs in the Annan Highlands in central Vietnam near the Laos border. C. bifida occurs in North Vietnam; its distribution extends across the border into adjacent localities in Guangxi and Yunnan in China. For the comparability between them,theywere considered as the same species C. micholitzii by many academicians. The cpDNA sequences from 11 populations showed that these very controversial species, C. micholitzii and C. bifida, is paraphyletic and should belong to the same species C. micholitzii. AMOVA analysis showed that the component of among-population within region/species (76.46%) was unexpectedly larger than the among-species/region component (14.97%), which also indicates that there is no justification for recognizing two species as C. micholitzii and C. bifida. This hypothesis was also supported by the geological data, especially the neotectonic history of the indo-china block, which started to move south since Oligocene and cause the geographic isolation of these two groups. Therefore, the most likely explanation to the phenotypic similarities between these two groups may be the retention of ancestral polymorphisms in the paraphyletic group due to incomplete lineage sorting. Furthermore, the similarities may also be ascribed to pollen-mediated gene flow among geographically proximate populations and/or phenotypic convergence under similar selection schemes in the same region. C.micholitzi had the higest genetic diversity (HT = 0.980,) and genetic differentiation (GST = 0.830, NST = 0.915) among the C. micholitzii complex. The high genetic diversity might be attributed to its long evolutionary history, highly diverse habitats. The ineffective mode of seed dispersal and dramatic neotectonic movement in the distribution range of this species could result in the high genetic differentiation. 2. Phylogeographic analysis based on nuclear ribosomal sequences, We sequenced the nrDNA ITS in all 27 populations sampled, 7 haplotypes were identified, among which C. micholitzii had 6, while C. multipinnata, C. longipetiolula and C. debaoensis shared the remaining one. Compared to chloroplast genes, nuclear genes had higher correlation between genetic and geographical distance, but lower interspecies differentiation (54.42% vs 25.24%). Phylogeographical structure of C. micholitzii and C.bifida based on ITS Variation was consistent with the morphology differentiation. This similar in nuclear gene should be ascribed to pollen-mediated gene flow among geographically proximate populations.Long-distance gene flow over the two groups was clearly interrupted, which brought on the nrDNA genetic differenciation between the geographically isolated groups, to a certain extent affected the morphological variation. 3. Interspecies relationships among Cycas micholitzii complex, We analysed chloroplast sequence variation of the atpB-rbcL and psbA-trnH intergenic spacers in 27 populations sampled of C. micholitzii complex, AMOVA analysis showed that the component of among-species/region component (59.21%). However, phylogenic analysis showed that the haplotypes of C. micholitzii complex couldn`t grouped into four clusters closely corresponding to the narrowly defined C. micholitzi, C. multipinnata, C. debaoensis and C. longipetiolula. We concluded that the conflict may result from several factors: firstly incomplete lineage sorting of C. micholitzii; secondly hybridization/introgression of sympatrically cycads, which would be supported by evidence base on nrDNA ITS sequences; thirdly intramolecular recombination in cpDNA of cycads; eventually the neotectonic movement in the distribution range of this 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UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations Eph antagonist and angiogenesis
期刊论文
出版物, 3111, 期号: 0, 页码: 1-32
作者:
I Hassan-Mohamed
;
C Giorgio
;
M Incerti
;
S Russo
;
D Pala
;
E B Pasquale
;
P Vicini
;
E Barocelli
;
S Rivara
;
M Mor
;
A Lodola
;
M Tognolini
Adobe PDF(1403Kb)
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浏览/下载：312/1
|
提交时间：2017/07/24
Eph Kinase
Ephrin
Small Molecules
Angiogenesis
Bile Acid
Lithocholic Acid
Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal through inhibition of STAT3 pathway
期刊论文
出版物, 3111, 期号: 0, 页码: 1-50
作者:
Jung Ok Ban
;
Dae Hwan Kim
;
Hee Pom Lee
;
Chul Ju Hwang
;
Jung-Hyun Shim
;
Dae Joong Kim
;
Tae Myoung Kim
;
Heon Sang Jeong
;
Seong Su Nah
;
Hanyong Chen
;
Zigang Dong
;
Young Wan Ham
;
Youngsoo Kim
;
Sang-Bae Han
;
Jin Tae Hong
Adobe PDF(1327Kb)
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浏览/下载：217/3
|
提交时间：2017/07/24
Evolutionary ecology of plant-plant interactions
期刊论文
出版物, 3111, 页码: 1-144
作者:
Zuo Z(作者)
Adobe PDF(717Kb)
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浏览/下载：259/4
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提交时间：2017/07/19
Structural and mechanistic basis of penicillin-bindingprotein inhibition by lactivicins
期刊论文
NATURE CHEMICAL BIOLOGY, 3111, 期号: 0, 页码: 1—5
作者:
Pauline Macheboeuf
;
Delphine S Fischer
;
Tom Brown Jr
;
Astrid Zervosen
;
Andre´Luxen
;
Bernard Joris
;
Andrea Dessen
;
Christopher J Schofield
Adobe PDF(425Kb)
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浏览/下载：120/1
|
提交时间：2017/07/21
Fundamental issues insystems biology
期刊论文
Problems & paradigms, 3111, 页码: 1270–1276
作者:
Sayaka Taji
;
Takeshi Yamada
;
Yasuko In
;
Shun-ichi Wada
;
Yoshihide Usami
;
Kazuo Sakuma
;
Reiko Tanaka
Adobe PDF(84Kb)
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浏览/下载：151/1
|
提交时间：2017/07/19
Data Analysisin Vegetation Ecology
期刊论文
出版物, 3111, 期号: 0, 页码: 1-297
作者:
Otto Wildi
Adobe PDF(3432Kb)
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浏览/下载：172/2
|
提交时间：2017/07/24
New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
期刊论文
Molecules, 2023
作者:
Qianqian Meng
;
Shunyao Tong
;
Yuqing Zhao
;
Xingrong Peng
;
Zhenghui Li
;
Tao Feng
;
Jikai Liu
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|
Adobe PDF(1414Kb)
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浏览/下载：483/78
|
提交时间：2023/10/07
Steccherins A-D, chamigrane-type sesquiterpenes from the fungus Steccherinum ochraceum with selective inhibition on B lymphocyte proliferation
期刊论文
PHYTOCHEMISTRY, 2023, 卷号: 214, 页码: 113830
作者:
Huang,Shan-Shan
;
Yang,Hui-Xiang
;
He,Juan
;
Yan,Bing-Chao
;
Feng,Tao
;
Liu,Ji-Kai
浏览
|
Adobe PDF(1256Kb)
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浏览/下载：17/8
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提交时间：2024/07/25
Steccherinum ochraceum
Chamigrane sesquiterpenes
Steccherins A-D
Immunosuppressive activity
Meroterpenoids from Ganoderma petchii inhibiting migration of triple negative breast cancer cells
期刊论文
FITOTERAPIA, 2023, 卷号: 167, 页码: 105505
作者:
Zhang,Jiao-Jiao
;
Guo,Ping-Xia
;
Yang,Zhong-Hui
;
Cai,Dan
;
Dai,Wei-Feng
;
Lu,Qing
;
Cheng,Yong-Xian
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Adobe PDF(3320Kb)
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浏览/下载：17/6
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提交时间：2024/07/25
Ganoderma petchii
Meroterpenoids
Triple negative breast cancer
Cell migration
Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel
期刊论文
FOOD CHEMISTRY, 2022, 卷号: 376, 页码: 131923
作者:
Hu,Guilin
;
Dong,Ding
;
Du,Shuzong
;
Peng,Xingrong
;
Wu,Mingkun
;
Shi,Qiangqiang
;
Hu,Kun
;
Hong,Defu
;
Wang,Xiaoyuan
;
Zhou,Lin
;
Nian,Yin
;
Qiu,Minghua
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Adobe PDF(4722Kb)
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浏览/下载：219/73
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提交时间：2022/04/02
Coffea arabica L
Roasted coffee
Coffee diterpenoid
Cafestol
Kahweol
T-type Ca2+ channels
Ca(v)3.1 low voltage-gated Ca2+ channel
Ca(v)3.1 inhibitors
CALCIUM-CHANNELS
CAFESTOL
KAHWEOL
PHYSIOLOGY
ESTERS
NOMENCLATURE
PHARMACOLOGY
APOPTOSIS
FURANS
