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Steccherins A-D, chamigrane-type sesquiterpenes from the fungus Steccherinum ochraceum with selective inhibition on B lymphocyte proliferation
Huang,Shan-Shan; Yang,Hui-Xiang; He,Juan; Yan,Bing-Chao; Feng,Tao; Liu,Ji-Kai
2023
发表期刊PHYTOCHEMISTRY
ISSN1873-3700
卷号214页码:113830
摘要Four previously undescribed chamigrane sesquiterpenes, namely steccherins A-D, have been isolated from the fungus Steccherinum ochraceum. Their structures were elucidated by extensive spectroscopic analysis, as well as computational methods and single crystal X-ray diffraction. Steccherins A and B possess previously undescribed backbones which might be derived from normal chamigrane sesquiterpenes, especially that steccherin A pos-sesses a spiro[5.6]dodecane carbon skeleton via a ring-rearrangement. Steccherins A, C, and D showed immu-nosuppressive activity with IC50 values ranging from 6.2 to 37.8 mu M. The data suggested that these chamigrane sesquiterpenes have potential selective inhibition on LPS-induced B lymphocyte proliferation.
关键词Steccherinum ochraceum Chamigrane sesquiterpenes Steccherins A-D Immunosuppressive activity
DOI10.1016/j.phytochem.2023.113830
收录类别SCI
WOS记录号WOS:001144744800001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/75524
专题中国科学院昆明植物研究所
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GB/T 7714
Huang,Shan-Shan,Yang,Hui-Xiang,He,Juan,et al. Steccherins A-D, chamigrane-type sesquiterpenes from the fungus Steccherinum ochraceum with selective inhibition on B lymphocyte proliferation[J]. PHYTOCHEMISTRY,2023,214:113830.
APA Huang,Shan-Shan,Yang,Hui-Xiang,He,Juan,Yan,Bing-Chao,Feng,Tao,&Liu,Ji-Kai.(2023).Steccherins A-D, chamigrane-type sesquiterpenes from the fungus Steccherinum ochraceum with selective inhibition on B lymphocyte proliferation.PHYTOCHEMISTRY,214,113830.
MLA Huang,Shan-Shan,et al."Steccherins A-D, chamigrane-type sesquiterpenes from the fungus Steccherinum ochraceum with selective inhibition on B lymphocyte proliferation".PHYTOCHEMISTRY 214(2023):113830.
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