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Cytotoxicity of naturally occurring rhamnofolane diterpenes from Jatropha curcas 期刊论文
PHYTOCHEMISTRY, 2013, 卷号: 96, 页码: 265-272
作者:  Liu, Jie-Qing;  Yang, Yuan-Feng;  Li, Xu-Yang;  Liu, En-Qian;  Li, Zhong-Rong;  Zhou, Lin;  Li, Yan;  Qiu, Ming-Hua
浏览  |  Adobe PDF(915Kb)  |  收藏  |  浏览/下载：282/98  |  提交时间：2015/05/14
Jatropha Curcas  Euphorbiaceae  Rhamnofolane Diterpenoids  Cytotoxicity  
Scapiformolactones A-I: Germacrane sesquiterpenoids with an unusual Delta(3)-15,6-lactone moiety from Salvia scapiformis 期刊论文
PHYTOCHEMISTRY, 2013, 卷号: 96, 页码: 378-388
作者:  Lai, Yongji;  Xue, Yongbo;  Zhang, Mengke;  Zhang, Jinwen;  Tang, Wei;  Liu, Junjun;  Lei, Liang;  Yan, Juming;  Luo, Zengwei;  Zuo, Jianping;  Li, Yan;  Yao, Guangmin;  Zhang, Yonghui
浏览  |  Adobe PDF(1398Kb)  |  收藏  |  浏览/下载：248/48  |  提交时间：2015/05/12
Salvia Scapiformis  Lamiaceae  Germacrane Sesquiterpene  Conformation  Chemical Transformation  Quantum Mechanical Calculation  Cytotoxicity Immunomodulatory Activity  
Gardovatine, a novel Strychnos-Strychnos bisindole alkaloid with cytotoxicity from Gardneria oveta 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 20, 页码: 5563-5565
作者:  Feng, Tao;  Li, Xiao-Ning;  Zhang, Bao-Hong;  Li, Yan;  Cai, Xiang-Hai;  Liu, Ya-Ping;  Luo, Xiao-Dong
浏览  |  Adobe PDF(480Kb)  |  收藏  |  浏览/下载：289/55  |  提交时间：2013/10/16
Gardneria Ovata  Gardovatine  Cytotoxicity  
New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas 期刊论文
FITOTERAPIA, 2013, 卷号: 89, 页码: 278-284
作者:  Yang, Yuan-Feng;  Liu, Jie-Qing;  Li, Zhong-Rong;  Li, Yan;  Qiu, Ming-Hua
浏览  |  Adobe PDF(747Kb)  |  收藏  |  浏览/下载：298/77  |  提交时间：2013/10/16
Jatropha Curcas  Euphorbiaceae  Sesquiterpenoid  Germacranolide  Eudesmanolide  Cytotoxicity  
Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 7, 页码: 1267-1277
作者:  Zhan, Rui;  Li, Xiao-Nian;  Du, Xue;  Wang, Wei-Guang;  Dong, Ke;  Su, Jia;  Li, Yan;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(448Kb)  |  收藏  |  浏览/下载：480/233  |  提交时间：2013/10/16
Lasiocarpus Hayata Kudo  Nf-kappa-b  Leukemic-cells  Terpenoids  Rubescens  Differentiation  Cytotoxicity  Constituents  Pharicin  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：259/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica) 期刊论文
PLANTA MEDICA, 2013, 卷号: 79, 期号: 1, 页码: 60-69
作者:  Nian, Yin;  Wang, Hai-Yan;  Zhou, Lin;  Su, Jia;  Li, Yan;  Qiu, Ming-Hua
Adobe PDF(185Kb)  |  收藏  |  浏览/下载：653/76  |  提交时间：2013/03/18
Ranunculaceae  Cimicifuga Dahurica  Cycloartane Triterpenes  Cytotoxicity  Structure-activity Relationships