New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas
Yang, Yuan-Feng1,2; Liu, Jie-Qing1; Li, Zhong-Rong1; Li, Yan1; Qiu, Ming-Hua1,2
Corresponding AuthorQiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China. ; mhchiu@mail.kib.ac.cn
2013-09-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume89Pages:278-284
AbstractThree new eudesmenoic acid methyl esters (1-3), as well as five known compounds, including three germacranolides (4-6) and two eudesmanolides (7 and 8), were isolated from the seed oil of Jatropha curcas. The new compounds were elucidated by means of spectroscopic methods, including extensive NMR spectra. In addition, the structure of 8 was confirmed by a single-crystal X-ray diffraction analysis. Among the isolates, compounds 4-6 were the first reported from the genus Jatropha. Using MTS viability assay, the cytotoxicity of compounds 2-8 were evaluated against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. Compounds 4 and 5 showed remarkable cytotoxicity against all the tested cell lines with IC50 values from 0.5 to 3.5 mu M, and the new compound 3 displayed selective cytotoxic activity against A-549 cell with an IC50 value of 7.24 mu M, but slight cytotoxicity against HL-60 and MCF-7 with IC50 values of 23.77 and 22.37 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved.
KeywordJatropha Curcas Euphorbiaceae Sesquiterpenoid Germacranolide Eudesmanolide Cytotoxicity
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000323856500033
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16681
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,et al. New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas[J]. FITOTERAPIA,2013,89:278-284.
APA Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,Li, Yan,&Qiu, Ming-Hua.(2013).New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas.FITOTERAPIA,89,278-284.
MLA Yang, Yuan-Feng,et al."New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas".FITOTERAPIA 89(2013):278-284.
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