New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas
Yang, Yuan-Feng1,2; Liu, Jie-Qing1; Li, Zhong-Rong1; Li, Yan1; Qiu, Ming-Hua1,2
2013-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号89页码:278-284
摘要Three new eudesmenoic acid methyl esters (1-3), as well as five known compounds, including three germacranolides (4-6) and two eudesmanolides (7 and 8), were isolated from the seed oil of Jatropha curcas. The new compounds were elucidated by means of spectroscopic methods, including extensive NMR spectra. In addition, the structure of 8 was confirmed by a single-crystal X-ray diffraction analysis. Among the isolates, compounds 4-6 were the first reported from the genus Jatropha. Using MTS viability assay, the cytotoxicity of compounds 2-8 were evaluated against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. Compounds 4 and 5 showed remarkable cytotoxicity against all the tested cell lines with IC50 values from 0.5 to 3.5 mu M, and the new compound 3 displayed selective cytotoxic activity against A-549 cell with an IC50 value of 7.24 mu M, but slight cytotoxicity against HL-60 and MCF-7 with IC50 values of 23.77 and 22.37 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved.
关键词Jatropha Curcas Euphorbiaceae Sesquiterpenoid Germacranolide Eudesmanolide Cytotoxicity
资助信息Chinese Ministry of Science and Technology [2007BAD32B01-03, SB2007FY400]; National Natural Science Foundation of China [81202437]; National Knowledge Innovation Program of Chinese Academy of Sciences [KSCX2-YW-G-038]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16681
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,et al. New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas[J]. FITOTERAPIA,2013,89:278-284.
APA Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,Li, Yan,&Qiu, Ming-Hua.(2013).New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas.FITOTERAPIA,89,278-284.
MLA Yang, Yuan-Feng,et al."New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas".FITOTERAPIA 89(2013):278-284.
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