| New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas | |
Yang, Yuan-Feng1,2; Liu, Jie-Qing1; Li, Zhong-Rong1; Li, Yan1 ; Qiu, Ming-Hua1,2
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| 通讯作者 | Qiu, MH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 2013-09-01 | |
| 发表期刊 | FITOTERAPIA
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| ISSN | 0367-326X |
| 卷号 | 89页码:278-284 |
| 摘要 | Three new eudesmenoic acid methyl esters (1-3), as well as five known compounds, including three germacranolides (4-6) and two eudesmanolides (7 and 8), were isolated from the seed oil of Jatropha curcas. The new compounds were elucidated by means of spectroscopic methods, including extensive NMR spectra. In addition, the structure of 8 was confirmed by a single-crystal X-ray diffraction analysis. Among the isolates, compounds 4-6 were the first reported from the genus Jatropha. Using MTS viability assay, the cytotoxicity of compounds 2-8 were evaluated against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. Compounds 4 and 5 showed remarkable cytotoxicity against all the tested cell lines with IC50 values from 0.5 to 3.5 mu M, and the new compound 3 displayed selective cytotoxic activity against A-549 cell with an IC50 value of 7.24 mu M, but slight cytotoxicity against HL-60 and MCF-7 with IC50 values of 23.77 and 22.37 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved. |
| 关键词 | Jatropha Curcas Euphorbiaceae Sesquiterpenoid Germacranolide Eudesmanolide Cytotoxicity |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323856500033 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16681 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,et al. New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas[J]. FITOTERAPIA,2013,89:278-284. |
| APA | Yang, Yuan-Feng,Liu, Jie-Qing,Li, Zhong-Rong,Li, Yan,&Qiu, Ming-Hua.(2013).New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas.FITOTERAPIA,89,278-284. |
| MLA | Yang, Yuan-Feng,et al."New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas".FITOTERAPIA 89(2013):278-284. |
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