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题名: New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas
作者: Yang, Yuan-Feng1, 2; Liu, Jie-Qing1; Li, Zhong-Rong1; null(李艳)1; null(邱明华)1, 2
刊名: FITOTERAPIA
关键词: Jatropha curcas ; Euphorbiaceae ; Sesquiterpenoid ; Germacranolide ; Eudesmanolide ; Cytotoxicity
英文摘要: Three new eudesmenoic acid methyl esters (1-3), as well as five known compounds, including three germacranolides (4-6) and two eudesmanolides (7 and 8), were isolated from the seed oil of Jatropha curcas. The new compounds were elucidated by means of spectroscopic methods, including extensive NMR spectra. In addition, the structure of 8 was confirmed by a single-crystal X-ray diffraction analysis. Among the isolates, compounds 4-6 were the first reported from the genus Jatropha. Using MTS viability assay, the cytotoxicity of compounds 2-8 were evaluated against HL-60, SMMC-7721, A-549, MCF-7, and SW480 human tumor cell lines. Compounds 4 and 5 showed remarkable cytotoxicity against all the tested cell lines with IC50 values from 0.5 to 3.5 mu M, and the new compound 3 displayed selective cytotoxic activity against A-549 cell with an IC50 value of 7.24 mu M, but slight cytotoxicity against HL-60 and MCF-7 with IC50 values of 23.77 and 22.37 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved.
出版日期: 2013-09-01
卷号: 89, 页码:278-284
语种: 英语
收录类别: SCI
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
ISSN号: 0367-326X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16681
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Yang, Yuan-Feng; Liu, Jie-Qing; Li, Zhong-Rong; Li, Yan; Qiu, Ming-Hua.New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas,FITOTERAPIA,2013,89():278-284
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文件名: Yang-2013-New eudesmenoic acid.pdf
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