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The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury 期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
作者:  Hu, Dan-Dan;  Zhao, Qi;  Cheng, Yan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Qu, Yan;  Li, Xian;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(1740Kb)  |  收藏  |  浏览/下载：223/28  |  提交时间：2020/03/26
liver injury  metabolomics  PPAR alpha  acylcarnitines  
Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 29, 页码: 8243-8252
作者:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Zhu, Xu;  Xiao, Xue-Rong;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(3136Kb)  |  收藏  |  浏览/下载：185/61  |  提交时间：2019/09/10
elemicin  l'-hydroxyelemicin  metabolic activation  cytotoxicity  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
作者:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(3915Kb)  |  收藏  |  浏览/下载：243/41  |  提交时间：2019/07/29
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
作者:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(1101Kb)  |  收藏  |  浏览/下载：262/110  |  提交时间：2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)  
Metabolic Activation of Myristicin and Its Role in Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 15, 页码: 4328-4336
作者:  Zhu, Xu;  Wang, Yi-Kun;  Yang, Xiao-Nan;  Xiao, Xue-Rong;  Zhang, Ting;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Li, Fei
浏览  |  Adobe PDF(4316Kb)  |  收藏  |  浏览/下载：235/43  |  提交时间：2019/05/24
myristicin  1 '-hydroxymyristicin  metabolic activation  metabolomics  
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling 期刊论文
MOLECULAR & CELLULAR PROTEOMICS, 2019, 卷号: 18, 期号: 3, 页码: 520-533
作者:  Zhao, Qi;  Liu, Fang;  Cheng, Yan;  Xiao, Xue-Rong;  Hu, Dan-Dan;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(4782Kb)  |  收藏  |  浏览/下载：184/61  |  提交时间：2019/07/29
Modulation of Lipid Metabolism by Celastrol 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2019, 卷号: 18, 期号: 3, 页码: 1133-1144
作者:  Zhang, Ting;  Zhao, Qi;  Xiao, Xuerong;  Yang, Rui;  Hu, Dandan;  Zhu, Xu;  Gonzalez, Frank J.;  Li, Fei
浏览  |  Adobe PDF(5774Kb)  |  收藏  |  浏览/下载：318/68  |  提交时间：2019/04/15
celastrol  lipidomics  hyperlipidemia  LC-MS  
Statistically correlating NMR spectra and LC-MS data to facilitate the identification of individual metabolites in metabolomics mixtures 期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 卷号: 411, 期号: 7, 页码: 1301-1309
作者:  Li, Xing;  Luo, Huan;  Huang, Tao;  Xu, Li;  Shi, Xiaohuo;  Hu, Kaifeng
浏览  |  Adobe PDF(1588Kb)  |  收藏  |  浏览/下载：198/47  |  提交时间：2019/07/29
Deconvolution  LC-MS  NMR  Statistical correlation  Structure identification  
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:  Lin, Xin;  Tian, Dongsong;  Fu, Yanhui;  Li, Yanan;  Huang, Liejun;  Gu, Wei;  Song, Jialei;  Li, Yanmei;  Ben-David, Yaacov;  Wen, Min;  Yuan, Chunmao;  Hao, Xiaojiang
浏览  |  Adobe PDF(2607Kb)  |  收藏  |  浏览/下载：296/50  |  提交时间：2019/03/18
Polycyclic polyprenylated acylphloroglucinol  Chemical transformation  Cytotoxicity  Cell apoptosis  Cell cycle arrest  
The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans 期刊论文
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019, 页码: 14
作者:  Wan, Qin-Li;  Yang, Zhong-Lin;  Zhou, Xiao-Gang;  Ding, Ai-Jun;  Pu, Yuan-Zhu;  Luo, Huai-Rong;  Wu, Gui-Sheng
浏览  |  Adobe PDF(2720Kb)  |  收藏  |  浏览/下载：182/22  |  提交时间：2019/07/29