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Redox Dual-Responsive and O-2-Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors 期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 1, 页码: 90-103
作者:  Chen, Huachao;  Li, Fei;  Yao, Yongrong;  Wang, Zhe;  Zhang, Zhihao;  Tan, Ninghua
浏览  |  Adobe PDF(3409Kb)  |  收藏  |  浏览/下载：213/55  |  提交时间：2019/07/29
cancer  theranostic system  hypoxic tumor  ROS/GSH dual-activatable  cyclopeptide RA-V  fluorescence imaging  
Systematic characterization and quantification of Rubiaceae-type cyclopeptides in 20 Rubia species by ultra performance liquid chromatography tandem mass spectrometry combined with chemometrics 期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2018, 卷号: 1581, 页码: 43-54
作者:  Zhang, Xuejia;  Bi, Qirui;  Wu, Xingdong;  Wang, Zhe;  Miao, Yuanyuan;  Tan, Ninghua
收藏  |  浏览/下载：85/0  |  提交时间：2019/03/29
Rubiaceae-type cyclopeptides  Rubia  UPLC-QqQ-MS/MS  Multiple reaction monitoring  Chemometric approach  Chemotaxonomy  
Natural cyclopeptide RA-V inhibits the NF-kappa B signaling pathway by targeting TAK1 期刊论文
CELL DEATH & DISEASE, 2018, 卷号: 9, 页码: 715
作者:  Wang, Zhe;  Zhao, Simeng;  Song, Lihua;  Pu, Yuzhi;  Wang, Qiang;  Zeng, Guangzhi;  Liu, Xing;  Bai, Ming;  Li, Shao;  Gao, Fabao;  Chen, Lijuan;  Wang, Chen;  Tan, Ninghua
收藏  |  浏览/下载：91/0  |  提交时间：2019/03/29
Rubicordins A-C, new cyclopeptides from Rubia cordifolia with cytotoxicity and inhibiting NF-kappa B signaling pathway 期刊论文
TETRAHEDRON, 2015, 卷号: 71, 期号: 52, 页码: 9673-9678
作者:  Chen, Xiao-Qiang;  Zhao, Si-Meng;  Wang, Zhe;  Zeng, Guang-Zhi;  Huang, Mao-Bo;  Tan, Ning-Hua
浏览  |  Adobe PDF(1412Kb)  |  收藏  |  浏览/下载：708/147  |  提交时间：2016/02/01
Rubia Cordifolia  Rubicordins A-c  Cyclopeptides  Cytotoxicity  Nf-kappa b Signaling Pathway  
Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity 期刊论文
PLOS ONE, 2015, 卷号: 10, 期号: 12
作者:  Wang, Zhe;  Zhao, Si-Meng;  Zhao, Li-Mei;  Chen, Xiao-Qiang;  Zeng, Guang-Zhi;  Tan, Ning-Hua
浏览  |  Adobe PDF(805Kb)  |  收藏  |  浏览/下载：708/187  |  提交时间：2016/02/01
Cyclopeptide RA-V inhibits cell adhesion and invasion in both estrogen receptor positive and negative breast cancer cells via PI3K/AKT and NF-kappa B signaling pathways 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2015, 卷号: 1853, 期号: 8, 页码: 1827-1840
作者:  Leung, Hoi-Wing;  Wang, Zhe;  Yue, Grace Gar-Lee;  Zhao, Si-Meng;  Lee, Julia Kin-Ming;  Fung, Kwok-Pui;  Leung, Ping-Chung;  Lau, Clara Bik-San;  Tan, Ning-Hua;  Lau,CBS (reprint author),Chinese Univ Hong Kong,Inst Chinese Med,Shatin,Hong Kong,Peoples R China.;  claralau@cuhk.edu.hk;  nhtan@mail.kib.ac.cn
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Cyclopeptide  Cell Adhesion  Cell Invasion  Metastasis  Breast Cancer  
New Cytotoxic Naphthohydroquinone Dimers from Rubia alata 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 21, 页码: 5576-5579
作者:  Zhao, Si-Meng;  Wang, Zhe;  Zeng, Guang-Zhi;  Song, Wei-Wu;  Chen, Xiao-Qiang;  Li, Xiao-Nian;  Tan, Ning-Hua;  Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.;  gzh_zeng@mail.kib.ac.cn;  nhtan@mail.kib.ac.cn
浏览  |  Adobe PDF(253Kb)  |  收藏  |  浏览/下载：269/55  |  提交时间：2015/01/20
Chiral Bicyclic Lactams  1st Total-synthesis  Asymmetric-synthesis  Helquist Annulation  Magellanine-type  L-paniculatum  (-)-8-deoxyserratinine  
Rubischumanins A-C, new cytotoxic cyclopeptides from Rubia schumanniana 期刊论文
TETRAHEDRON, 2014, 卷号: 70, 期号: 42, 页码: 7627-7631
作者:  Huang, Mao-Bo;  Zhao, Si-Meng;  Zeng, Guang-Zhi;  Kuang, Bin;  Chen, Xiao-Qiang;  Tan, Ning-Hua;  Zeng,GZ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.;  gzh_zeng@mail.kib.ac.cn;  nhtan@mail.kib.ac.cn
Adobe PDF(498Kb)  |  收藏  |  浏览/下载：407/64  |  提交时间：2014/11/25
Rubia Schumanniana  Rubischumanins A-c  Cyclopeptides  Cytotoxicity  
Synthesis and conformation studies of rubiyunnanin B analogs 期刊论文
TETRAHEDRON, 2014, 卷号: 70, 期号: 37, 页码: 6630-6640
作者:  Liu, Na-Na;  Zhao, Si-Meng;  Zhao, Jing-Feng;  Zeng, Guang-Zhi;  Tan, Ning-Hua;  Liu, Jian-Ping;  Tan, NH (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China.;  nhtan@mail.kib.ac.cn;  jpliu@ynu.edu.cn
Adobe PDF(619Kb)  |  收藏  |  浏览/下载：227/56  |  提交时间：2014/10/11
Rubiyunnanin b Analogs  Synthesis  Conformation Studies  Bioactivities  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：275/45  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.