Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity

doi:10.1371/journal.pone.0144950

	Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity
	Wang, Zhe; Zhao, Si-Meng; Zhao, Li-Mei; Chen, Xiao-Qiang; Zeng, Guang-Zhi; Tan, Ning-Hua
	2015-12-22
发表期刊	PLOS ONE
卷号	10 期号:12
摘要	One new cyclic hexapeptide named rubipodanin A (1), which is the first identified natural N-desmonomethyl Rubiaceae-type cyclopeptide, together with six known Rubiaceae-type cyclopeptides (2-7) were obtained using the TLC cyclopeptide protosite detection method with ninhydrin from the roots and rhizomes of Rubia podantha. The cyclopeptide structures were elucidated by extensive spectroscopic analysis, including 1D-NMR, 2D-NMR, IR, UV and MS. The solution conformation and biological activities of 1 and RA-V (4) were evaluated, and the results demonstrated that the N-9-methyl group plays a vital role in the maintenance of the conformation and bioactivity.
DOI	10.1371/journal.pone.0144950
收录类别	SCI
语种	英语
WOS记录号	WOS:000367092500017
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25332
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Wang, Zhe,Zhao, Si-Meng,Zhao, Li-Mei,et al. Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity[J]. PLOS ONE,2015,10(12).
APA	Wang, Zhe,Zhao, Si-Meng,Zhao, Li-Mei,Chen, Xiao-Qiang,Zeng, Guang-Zhi,&Tan, Ning-Hua.(2015).Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity.PLOS ONE,10(12).
MLA	Wang, Zhe,et al."Rubipodanin A, the First Natural N-Desmonomethyl Rubiaceae-Type Cyclopeptide from Rubia podantha, Indicating an Important Role of the N-9-Methyl Group in the Conformation and Bioactivity".PLOS ONE 10.12(2015).

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