| Redox Dual-Responsive and O-2-Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors | |
Chen, Huachao1; Li, Fei2; Yao, Yongrong1; Wang, Zhe1 ; Zhang, Zhihao1; Tan, Ninghua1,2
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| 通讯作者 | Zhang, Zhihao(zzh-198518@163.com) ; Tan, Ninghua(nhtan@cpu.edu.cn) |
| 2019 | |
| 发表期刊 | THERANOSTICS
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| ISSN | 1838-7640 |
| 卷号 | 9期号:1页码:90-103 |
| 摘要 | Activatable theranostic agents, which combine fluorescent reporters with masked chemotherapeutic agents that are activated by tumor-associated stimuli, would be attractive candidates to improve the tumor selectivity of chemotherapy. This work reports a ROS/GSH dual-activatable and O-2-evolving theranostic nanosystem (RA-S-S-Cy@PLGA NPs) for highly selective therapy against hypoxic tumors and in situ fluorescence-tracking of cancer chemotherapy. Methods: In this system, the newly designed theranostic agent (RA-S-S-Cy) is composed of a disulfide bond as a cleavable linker, a near infrared (NIR) active fluorophore as a fluorescent tracker, and a natural cyclopeptide RA-V as the active anti-cancer agent. Upon reaction with the high level of intracellular glutathione (GSH), disulfide cleavage occurs, resulting in concomitant active drug RA-V release and significant NIR fluorescence increase. To further improve the tumor targeting of RA-S-S-Cy and achieve redox dual-responsiveness, RA-S-S-Cy was incorporated into the c(RGDfK)-targeted PLGA nanoparticles together with an O-2-generating agent (catalase) to produce RA-S-S-Cy@PLGA NPs. Results: The cell-specific and redox dual-activatable release of RA-V lead to enhanced therapeutic outcomes in vivo and in vitro. More significantly, the RA-S-S-Cy@PLGA NPs were successfully applied for monitoring of drug release and chemotherapeutic efficacy in situ by "turn-on" NIR fluorescence. Conclusions: RA-S-S-Cy@PLGA NPs would be efficient theranostic nanosystems for more precise therapy against hypoxic tumors and provides a potential tool for deeper understanding of drug release mechanisms. |
| 关键词 | cancer theranostic system hypoxic tumor ROS/GSH dual-activatable cyclopeptide RA-V fluorescence imaging |
| DOI | 10.7150/thno.30259 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000452508600008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67727 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zhang, Zhihao; Tan, Ninghua |
| 作者单位 | 1.China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Sch Tradit Chinese Pharm, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Huachao,Li, Fei,Yao, Yongrong,et al. Redox Dual-Responsive and O-2-Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors[J]. THERANOSTICS,2019,9(1):90-103. |
| APA | Chen, Huachao,Li, Fei,Yao, Yongrong,Wang, Zhe,Zhang, Zhihao,&Tan, Ninghua.(2019).Redox Dual-Responsive and O-2-Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors.THERANOSTICS,9(1),90-103. |
| MLA | Chen, Huachao,et al."Redox Dual-Responsive and O-2-Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors".THERANOSTICS 9.1(2019):90-103. |
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| Chen-2019-Redox Dual（3409KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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