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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
作者:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
浏览  |  Adobe PDF(17974Kb)  |  收藏  |  浏览/下载：28/18  |  提交时间：2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
Rubiginosin B selectively inhibits Treg cell differentiation and enhances anti-tumor immune responses by targeting calcineurin-NFAT signaling pathway 期刊论文
PHYTOMEDICINE, 2023, 卷号: 116, 页码: 154898
作者:  Geng,Chang-An;  Chen,Feng-Yang;  Zheng,Jing-Bin;  Liao,Ping;  Li,Tian-Ze;  Zhang,Xue-Mei;  Chen,Xin;  Chen,Ji-Jun
浏览  |  Adobe PDF(5670Kb)  |  收藏  |  浏览/下载：27/9  |  提交时间：2024/07/17
Rubiginosin B (RGB)  CD4(+)Foxp3(+) regulatory T cells (Tregs)  Calcineurin  Nuclear factor of activated T cells (NFAT)  Tumor microenvironment  Rhododendron brachypodum  REGULATORY T-CELLS  RHODODENDRON  IMMUNOSUPPRESSION  DERIVATIVES  INDUCTION  EXPANSION  RAPAMYCIN  
Rearranged Homoadamantane-Type Polycyclic Polyprenylated Acylphloroglucinols from Hypericum pseudohenryi 期刊论文
ORGANIC LETTERS, 2023, 卷号: 25, 期号: 50, 页码: 8965-8969
作者:  Jiang,Na-Na;  Ye,Yan-Song;  Liu,Xia;  Wang,Yong-Ling;  Xu,Gang
浏览  |  Adobe PDF(2041Kb)  |  收藏  |  浏览/下载：17/6  |  提交时间：2024/07/10
Identification of New Diterpenoids from the Pulp of Coffea arabica and Their α-Glucosidase Inhibition Activity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2023, 卷号: 72, 期号: 3, 页码: 1683-1694
作者:  Al-Romaima,Abdulbaset;  Hu,Guilin;  Wang,Yanbing;  Quan,Chenxi;  Dai,Haopeng;  Qiu,Minghua
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Coffeaarabica  coffee pulp  diterpenoids  structure elucidation  alpha-glucosidase  moleculardocking  ENT-KAURANE DITERPENES  ACID  PRODUCTS  EXTRACTS  CAFFEINE  CAFESTOL  ESTERS  BEANS  
Discovery of potential novel TRPC5 inhibitors by virtual screening and bioassay 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 94, 页码: 117477
作者:  Shen,Meiling;  Li,Lingfeng;  Li,Yue;  Gu,Xi;  Bai,Longhui;  Xia,Chengfeng;  Xiong,Wenyong;  Zuo,Zhili
浏览  |  Adobe PDF(6089Kb)  |  收藏  |  浏览/下载：25/8  |  提交时间：2024/07/22
TRPC5  Inhibitors  Virtual screening  Ca 2+channel  CHANNELS  IDENTIFICATION  PERMEABILITY  CALCIUM  
Discovery of 2-(Methylcarbonylamino) thiazole as PDE4 inhibitors via virtual screening and biological evaluation 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 124, 页码: 108567
作者:  Ma,Rui;  Song,Na;  Wang,Lveli;  Gu,Xi;  Xiong,Feng;  Zhang,Shuqun;  Zhang,Jie;  Yang,Weimin;  Zuo,Zhili
浏览  |  Adobe PDF(5778Kb)  |  收藏  |  浏览/下载：19/9  |  提交时间：2024/07/22
PHOSPHODIESTERASE-4 INHIBITOR  ACCURATE DOCKING  APREMILAST  EFFICACY  INSIGHTS  DISEASE  ASTHMA  POTENT  GLIDE  
Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2023, 卷号: 21, 期号: 6, 页码: 443-453
作者:  Tao,Linlan;  Xu,Shuangyu;  Zhang,Zizhen;  Li,Yanan;  Yang,Jue;  Gu,Wei;  Yi,Ping;  Hao,Xiaojiang;  Yuan,Chunmao
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Hypericum sampsonii  Chemical constituents  Structure elucidation  alpha-Glucosidase  Molecular docking  POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS  POTENT INHIBITORS  SPECTROSCOPY  DERIVATIVES  CHEMISTRY  AMYLASE  ROOTS  
Oligomeric phloroglucinols with hAChE inhibitory and antibacterial activities from tropic Rhodomyrtus tomentosa 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 106836
作者:  Luo,E-E;  Liu,Si-Na;  Wang,Zhao-Jie;  Chen,Ling-Yun;  Liang,Cheng-Qin;  Yu,Mu-Yuan;  Qin,Xu-Jie
浏览  |  Adobe PDF(3972Kb)  |  收藏  |  浏览/下载：21/8  |  提交时间：2024/07/22
Rhodomyrtus tomentosa  Oligomeric phloroglucinols  h AChE inhibitors  Molecular docking  Antibacterial effects  MYRTUCOMMULONE  DERIVATIVES  ACYLPHLOROGLUCINOLS  MYRTUCOMMUACETALONE  LEAVES  
Artemiprinolides A-M, thirteen undescribed sesquiterpenoid dimers from Artemisia princeps and their antihepatoma activity 期刊论文
PHYTOCHEMISTRY, 2023, 卷号: 211, 页码: 113714
作者:  Su,Li-Hua;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Tian-Ze;  Geng,Chang-An;  Dong,Wei;  He,Xiao-Feng;  Chen,Ji-Jun
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Artemisia princeps Pamp  Sesquiterpenoid dimers  Artemiprinolides A-M  Antihepatoma activity  Apoptosis  FARNESYL-PROTEIN TRANSFERASE  ETHANOL EXTRACT  PAMPANINI  INHIBITORS  JACEOSIDIN  
Structurally modified Cyclovirobuxine-D Buxus alkaloids as effective analgesic agents through Cav3.2 T-Type calcium channel inhibition 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 135, 页码: 106493
作者:  Munikishore,Rachakunta;  Liu,Rui;  Zhang,Shuqun;  Zhao,Qin-Shi;  Nian,Yin;  Zuo,Zhili
浏览  |  Adobe PDF(5035Kb)  |  收藏  |  浏览/下载：27/5  |  提交时间：2024/07/22
Buxus alkaloid  Structural modification  T -type calcium channel  Analgesic activity  Docking analysis  Structure -activity relationship study  BUXOZINE-C  SEMPERVIRENS  RING  CONSTITUTION