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Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
Authors:  Qu, Chunrong;  Ding, Mingmin;  Zhu, Yingmin;  Lu, Yungang;  Du, Juan;  Miller, Melissa;  Tian, Jinbin;  Zhu, Jinmei;  Xui, Jian;  Wen, Meng;  Er-Bu, Aga;  Wan, Jule;  Xiao, Yuling;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Wu, Jilin;  Luo, Huai-Rong;  Cao, Zhengyu;  Shen, Bing;  Wang, Hongbo;  Zhu, Michael X.;  Hong, Xuechuan
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Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way 期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2017, 卷号: 426, 期号: 1-2, 页码: 101-109
Authors:  Ding, Ai-Jun;  Wu, Gui-Sheng;  Tang, Bin;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
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Aging  Benzimidazole Derivative M084  Caenorhabditis Elegans  Lifespan  
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice 期刊论文
PLOS ONE, 2015, 卷号: 10, 期号: 8
Authors:  Yang, Li-Ping;  Jiang, Fang-Jie;  Wu, Gui-Sheng;  Deng, Ke;  Wen, Meng;  Zhou, Xiaoju;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
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Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 14, 页码: 3495-3509
Authors:  Zhu, Yingmin;  Lu, Yungang;  Qu, Chunrong;  Miller, Melissa;  Tian, Jinbin;  Thakur, Dhananjay P.;  Zhu, Jinmei;  Deng, Zixin;  Hu, Xianming;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
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吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用 专利
专利类型: 发明, 专利号: CN201310666552.1, 申请日期: 2013-12-10, 公开日期: 2014-04-02
Inventors:  罗怀容;  洪学传;  朱曦;  朱进妹;  吴桂生;  邓子新;  朱颖旻;  陆云刚;  邓科;  瞿春容
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Synthesis and neurotrophic activity evaluation of amaryllidaceae alkaloids 期刊论文
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 卷号: 246
Authors:  Luo, Huairong;  He, Maomao;  Zhu, Jinmei;  Wu, Chunfeng;  Deng, Zixin;  Hong, Xuechuan
Favorite  |  View/Download:95/0  |  Submit date:2015/05/14
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 14, 页码: 4218-4224
Authors:  Zhu, Jinmei;  Wu, Chun-Feng;  Li, Xiaobing;  Wu, Gui-Sheng;  Xie, Shan;  Hu, Qian-Nan;  Deng, Zixin;  Zhu, Michael X.;  Luo, Huai-Rong;  Hong, Xuechuan
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Alzheimer's Disease  Acetylcholinesterase  Butyrylcholinesterase  Molecular Modeling  2-aminobenzimidazole  
苯并咪唑及其衍生物,其药物组合物及其应用 专利
专利类型: 发明, 专利号: CN201210512291.3, 申请日期: 2012-12-04, 公开日期: 2013-05-29
Inventors:  罗怀容;  洪学传;  邓子新;  吴桂生;  丁爱军;  朱进妹;  邹系胜
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苯并咪唑及其衍生物,其药物组合物及其在制备抗抑郁药物中的应用 专利
专利类型: 发明, 专利号: CN201210512505.7, 申请日期: 2012-12-04, 公开日期: 2013-05-29
Inventors:  罗怀容;  洪学传;  邓子新;  吴桂生;  杨丽萍;  朱进妹;  刘磊
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Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters 期刊论文
GREEN CHEMISTRY, 2011, 卷号: 13, 期号: 10, 页码: 2723-2726
Authors:  Chen, Hao;  He, Maomao;  Wang, Yaya;  Zhai, Linhui;  Cui, Yongbo;  Li, Yangyan;  Li, Yan;  Zhou, Haibing;  Hong, Xuechuan;  Deng, Zixin
Adobe PDF(182Kb)  |  Favorite  |  View/Download:225/68  |  Submit date:2012/07/25
Native Chemical Ligation  Catalyzed Double Carbohydroamination  Amide Synthesis  Mild Amidation  One-pot  Oxidative Amidation  General-solution  Aldehydes  Alcohols  Efficient