Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice

doi:10.1371/journal.pone.0136255

	Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice
	Yang, Li-Ping; Jiang, Fang-Jie; Wu, Gui-Sheng; Deng, Ke; Wen, Meng; Zhou, Xiaoju; Hong, Xuechuan; Zhu, Michael X.; Luo, Huai-Rong
	2015-08-28
发表期刊	PLOS ONE
卷号	10 期号:8
摘要	Transient receptor potential canonical (TRPC) channels are widely expressed in brain and involved in various aspects of brain function. Both TRPC4 and TRPC5 have been implicated in innate fear function, which represents a key response to environmental stress. However, to what extent the TRPC4/C5 channels are involved in psychiatric disorders remains unexplored. Here, we tested the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084. We show that a single intraperitoneal administration of M084 at 10 mg/kg body weight to C57BL/6 male mice significantly shortened the immobility time in forced swim test and tail suspension test within as short as 2 hours. The M084-treated mice spent more time exploring in illuminated and open areas in light/dark transition test and elevated plus maze test. In mice subjected to chronic unpredictable stress, M084 treatment reversed the enhanced immobility time in forced swim test and decreased the latency to feed in novelty suppressed feeding test. The treatment of M084 increased BDNF expression in both mRNA and protein levels, as well as phosphorylation levels of AKT and ERK, in prefrontal cortex. Our results indicate that M084 exerts rapid antidepressant and anxiolytic-like effects at least in part by acting on BDNF and its downstream signaling. We propose M084 as a lead compound for further druggability research.
DOI	10.1371/journal.pone.0136255
收录类别	SCI
语种	英语
WOS记录号	WOS:000360299100067
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/25120
专题	植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Yang, Li-Ping,Jiang, Fang-Jie,Wu, Gui-Sheng,et al. Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice[J]. PLOS ONE,2015,10(8).
APA	Yang, Li-Ping.,Jiang, Fang-Jie.,Wu, Gui-Sheng.,Deng, Ke.,Wen, Meng.,...&Luo, Huai-Rong.(2015).Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.PLOS ONE,10(8).
MLA	Yang, Li-Ping,et al."Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice".PLOS ONE 10.8(2015).

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
asset.pdf（1207KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载