Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters

doi:10.1039/c1gc15401j

	Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters
	Chen, Hao 1,2; He, Maomao 1,2; Wang, Yaya 1,2; Zhai, Linhui 1,2; Cui, Yongbo 1,2; Li, Yangyan 1,2; Li, Yan3 ; Zhou, Haibing 1,2; Hong, Xuechuan 1,2; Deng, Zixin 1,2
通讯作者	Chen, H (reprint author), Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynthesis & Drug Discove, Wuhan 430071, Peoples R China
	2011
发表期刊	GREEN CHEMISTRY
ISSN	1463-9262
卷号	13 期号:10 页码:2723-2726
摘要	Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild conditions and demonstrates a high tolerance to functionality.
关键词	Native Chemical Ligation Catalyzed Double Carbohydroamination Amide Synthesis Mild Amidation One-pot Oxidative Amidation General-solution Aldehydes Alcohols Efficient
学科领域	Chemistry
DOI	10.1039/c1gc15401j
收录类别	SCI ; CCR
语种	英语
WOS记录号	WOS:000295579700017
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/14537
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynthesis & Drug Discove, Wuhan 430071, Peoples R China 2.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Chen, Hao,He, Maomao,Wang, Yaya,et al. Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters[J]. GREEN CHEMISTRY,2011,13(10):2723-2726.
APA	Chen, Hao.,He, Maomao.,Wang, Yaya.,Zhai, Linhui.,Cui, Yongbo.,...&Deng, Zixin.(2011).Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters.GREEN CHEMISTRY,13(10),2723-2726.
MLA	Chen, Hao,et al."Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters".GREEN CHEMISTRY 13.10(2011):2723-2726.

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