Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters
Chen, Hao1,2; He, Maomao1,2; Wang, Yaya1,2; Zhai, Linhui1,2; Cui, Yongbo1,2; Li, Yangyan1,2; Li, Yan3; Zhou, Haibing1,2; Hong, Xuechuan1,2; Deng, Zixin1,2
2011
发表期刊GREEN CHEMISTRY
ISSN1463-9262
卷号13期号:10页码:2723-2726
摘要Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters in the presence of bis(trimethylsilyl) acetamide (BSA) has been developed. This general method provides convenient access to N-protected peptides in good yields under mild conditions and demonstrates a high tolerance to functionality.
关键词Native Chemical Ligation Catalyzed Double Carbohydroamination Amide Synthesis Mild Amidation One-pot Oxidative Amidation General-solution Aldehydes Alcohols Efficient
资助信息National Mega Project on Major Drug Development[2009ZX09301-014-1]; NSFC[20872116, 91017005]; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2010-KF10]
学科领域Chemistry
DOI10.1039/c1gc15401j
收录类别SCI ; CCR
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000295579700017
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/14537
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynthesis & Drug Discove, Wuhan 430071, Peoples R China
2.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
推荐引用方式
GB/T 7714
Chen, Hao,He, Maomao,Wang, Yaya,et al. Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters[J]. GREEN CHEMISTRY,2011,13(10):2723-2726.
APA Chen, Hao.,He, Maomao.,Wang, Yaya.,Zhai, Linhui.,Cui, Yongbo.,...&Deng, Zixin.(2011).Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters.GREEN CHEMISTRY,13(10),2723-2726.
MLA Chen, Hao,et al."Metal-free direct amidation of peptidyl thiol esters with alpha-amino acid esters".GREEN CHEMISTRY 13.10(2011):2723-2726.
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