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Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020
作者:  Li, Xue;  Kong, Lingmei;  Yang, Qihong;  Duan, Aizhu;  Ju, Xiaoman;  Cai, Bicheng;  Chen, Lin;  An, Tao;  Li, Yan
浏览  |  Adobe PDF(2381Kb)  |  收藏  |  浏览/下载：123/56  |  提交时间：2021/01/05
Discovery of novel wee1 inhibitors via structure-based virtual screening and biological evaluation 期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2018, 卷号: 32, 期号: 9, 页码: 901-915
作者:  Li, Yaping;  Pu, Yinglan;  Liu, Hui;  Zhang, Li;  Liu, Xingyong;  Li, Yan;  Zuo, Zhili
收藏  |  浏览/下载：414/0  |  提交时间：2018/11/06
Wee1 inhibitors  Pharmacophore model  Molecular docking  Virtual screening  Molecular dynamics simulation  
microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 10, 页码: 16633-16641
作者:  Wei, Ran;  Yang, Qin;  Han, Bing;  Li, Yan;  Yao, Kun;  Yang, Xiuyu;  Chen, Zexi;  Yang, Shanshan;  Zhou, Jiaqi;  Li, Meizhang;  Yu, Haijing;  Yu, Min;  Cui, Qinghua
浏览  |  Adobe PDF(12068Kb)  |  收藏  |  浏览/下载：413/36  |  提交时间：2017/04/19
Microrna-375  Colorectal Cancer  Jak2/stat3 Pathway  Map3k8/erk Pathway  Atg7  
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
作者:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
浏览  |  Adobe PDF(3794Kb)  |  收藏  |  浏览/下载：170/36  |  提交时间：2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor  
The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin 期刊论文
MOLECULAR AND CELLULAR BIOLOGY, 2014, 卷号: 34, 期号: 23, 页码: 4355-4366
作者:  Ma, Pengcheng;  Yang, Xiangcai;  Kong, Qinghua;  Li, Chaocui;  Yang, Shuangjuan;  Li, Yan;  Mao, Bingyu;  Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.;  mao@mail.kiz.ac.cn
浏览  |  Adobe PDF(1708Kb)  |  收藏  |  浏览/下载：269/54  |  提交时间：2015/01/20
Stem-cell Fate  Shoot Apical Meristem  Arabidopsis Shoot  Crabs-claw  Nectary Development  Expression  Thaliana  Family  Loop  Polarity  Iayabby2  Ad-abaxial Polarity  Incarvillea Arguta  Arabidopsis Thaliana  
Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 7, 页码: 1267-1277
作者:  Zhan, Rui;  Li, Xiao-Nian;  Du, Xue;  Wang, Wei-Guang;  Dong, Ke;  Su, Jia;  Li, Yan;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(448Kb)  |  收藏  |  浏览/下载：466/227  |  提交时间：2013/10/16
Lasiocarpus Hayata Kudo  Nf-kappa-b  Leukemic-cells  Terpenoids  Rubescens  Differentiation  Cytotoxicity  Constituents  Pharicin  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：239/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.