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题名: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways
作者: Wei, Ran1, 2; Yang, Qin1; Han, Bing1, 3; Li, Yan1; Yao, Kun1; Yang, Xiuyu1; Chen, Zexi1, 3; Yang, Shanshan1; Zhou, Jiaqi1; Li, Meizhang1; Yu, Haijing1; Yu, Min1; Cui, Qinghua1, 2
刊名: ONCOTARGET
出版日期: 2017
卷号: 8, 期号:10, 页码:16633-16641
关键词: microRNA-375 ; colorectal cancer ; JAK2/STAT3 pathway ; MAP3K8/ERK pathway ; ATG7
DOI: 10.18632/oncotarget.15114
文章类型: Article
英文摘要: MicroRNA-375 is involved in many types of alimentary system cancers. Our previous studies showed that microRNA-375 was significantly down-regulated in carcinoma tissues compared with para-carcinoma tissues, which strongly indicates that microRNA-375 might suppress the occurrence and development of colorectal cancer. However, the mechanism underlying the microRNA-375 regulation in colorectal cancer remains unclear. In this study, we first sorted out jak2, map3k8 and atg7 as microRNA-375 targeted genes from multiple databases, and found that jak2, map3k8 and their downstream genes stat3 and erk were up-regulated in carcinoma tissues. Secondly, we over-expressed microRNA-375 in colorectal cancer cell lines (HCT116, Caco2 and HT29). Our results showed that in microRNA-375 over-expressing cells, JAK2/STAT3 and MAP3K8/ERK proteins were down-regulated, cell proliferation was inhibited, cell migration rate did not change. There was no significant difference on ATG7 expression between the control group and microRNA-375 over-expressing HT29/ Caco2 cells, whereas microRNA-375 down-regulated ATG7 specifically in HCT116 cells. Finally, we demonstrated that expressing microRNA-375 suppressed tumor formation in nude mice. In conclusion, microRNA-375 might function as a tumor-repressive gene to inhibit cell proliferation, mainly through targeting both JAK2/STAT3 and MAP3K8/ERK signaling pathways in colorectal cancer. These findings suggest miR-375 as a promising diagnostic marker and a therapeutic drug for colorectal cancer.
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: CARCINOMAS ; APOPTOSIS ; MAPK
收录类别: SCI
项目资助者: Natural Science Foundation of China(81360310 ; 31106237 ; 31260276 ; 81271330 ; 31471187 ; 31171215 ; w8110305)
语种: 英语
WOS记录号: WOS:000396024600045
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/46045
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Yunnan Univ, Sch Life Sci, Kunming 650091, Yunnan, Peoples R China
2.Yunnan Univ, Key Lab Tumor Mol Biol Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Wei, Ran,Yang, Qin,Han, Bing,et al. microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways[J]. ONCOTARGET,2017,8(10):16633-16641.
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文件名: 15114-224062-2-PB.pdf
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