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Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress 期刊论文
PHYTOMEDICINE, 2023, 卷号: 112, 页码: 154720
作者:  Niu,Zhenpeng;  Tang,Guihua;  Wang,Xuenan;  Yang,Xu;  Zhao,Yueqin;  Wang,Yinyuan;  Liu,Qin;  Zhang,Fan;  Zhao,Yuhan;  Ding,Xiao;  Hao,Xiaojiang
浏览  |  Adobe PDF(11543Kb)  |  收藏  |  浏览/下载：34/12  |  提交时间：2024/07/17
Lysosomal biogenesis  Autophagy  TFEB  TFE3  ER stress  IVDD  STAT3  TFE3  
Cytostatic Activity of Sanguinarine and a Cyanide Derivative in Human Erythroleukemia Cells Is Mediated by Suppression of c-MET/MAPK Signaling 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 9, 页码: 8113
作者:  Xu,Xinglian;  Deng,Lulu;  Tang,Yaling;  Li,Jiang;  Zhong,Ting;  Hao,Xiaojiang;  Fan,Yanhua;  Mu,Shuzhen
浏览  |  Adobe PDF(5829Kb)  |  收藏  |  浏览/下载：55/16  |  提交时间：2024/05/09
leukemia  sanguinarine  c-MET  MAPK  PI3K/mTOR  STAT3  MET  
Phylogenetic patterns suggest frequent multiple origins of secondary metabolites across the seed-plant 'tree of life' 期刊论文
NATIONAL SCIENCE REVIEW, 2021
作者:  Zhang,Yongzeng;  Deng,Tao;  Sun,Lu;  Landis,Jacob B.;  Moore,Michael J.;  Wang,Hengchang;  Wang,Yuehua;  Hao,Xiaojiang;  Chen,Jijun;  Li,Shenghong;  Xu,Maonian;  Puno,Pema-Tenzin;  Raven,Peter H.;  Sun,Hang
浏览  |  Adobe PDF(1313Kb)  |  收藏  |  浏览/下载：183/35  |  提交时间：2023/09/08
Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway 期刊论文
FITOTERAPIA, 2021, 卷号: 151, 页码: 104876
作者:  Yang,Hao-Jie;  Li,Ya-Nan;  Yan,Chen;  Yang,Jue;  Zeng,Yan-Rong;  Yi,Ping;  Li,Yan-Mei;  Hao,Xiao-Jiang;  Yuan,Chun-Mao
浏览  |  Adobe PDF(2804Kb)  |  收藏  |  浏览/下载：108/30  |  提交时间：2022/04/02
Dysoxylum gotadhora  Rocaglaol derivatives  HCT116  Cytotoxic activity  MAPK pathway  FLAVAGLINES  
Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2021, 卷号: 17, 期号: 11, 页码: 2703-2717
作者:  Wei,Ruiran;  Zhao,Yueqin;  Wang,Juan;  Yang,Xu;  Li,Shunlin;  Wang,Yinyuan;  Yang,Xingzhi;  Fei,Jimin;  Hao,Xiaojiang;  Zhao,Yuhan;  Gui,Liming;  Ding,Xiao
浏览  |  Adobe PDF(9123Kb)  |  收藏  |  浏览/下载：148/30  |  提交时间：2022/04/02
Ferroptosis  Tagitinin c  Ros  Er Stress  Nrf2-ho-1 Pathway  Endoplasmic-reticulum Stress  Er-stress  Oxidative Stress  Tumor-suppressor  Nrf2  Death  Iron  Differentiation  Mechanisms  Resistance  
Natural product sciences: an integrative approach to the innovations of plant natural products 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020
作者:  Shen, Yuemao;  Hao, Xiaojiang
浏览  |  Adobe PDF(4992Kb)  |  收藏  |  浏览/下载：139/24  |  提交时间：2021/01/05
A new acorane sesquiterpenes of Lysionotus pauciflorus maxim. Form Guizhou province, China 期刊论文
BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2020
作者:  Zhang, Jiayu;  Yi, Ping;  Xiong, Yan;  Du, Caixia;  Zhang, Yu;  Yuan, Chunmao;  Huang, Liejun;  Gu, Wei;  Hao, Xiaojiang
浏览  |  Adobe PDF(917Kb)  |  收藏  |  浏览/下载：188/58  |  提交时间：2021/01/05
12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata 期刊论文
NATURAL PRODUCT RESEARCH, 2019, 卷号: 33, 期号: 19, 页码: 2830-2836
作者:  Gui, Peng-Yan;  Yan, Xiao-Hui;  Yuan, Wen-Juan;  Ma, Yuan-Liang;  Ding, Xiao;  Liu, Shuai;  Di, Ying-Tong;  Zhu, Wei-Ming;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(919Kb)  |  收藏  |  浏览/下载：414/179  |  提交时间：2019/09/10
Harrisonia perforata  limonoid  12 beta-Acetyloxyperforatin  computational modelling  
Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2019, 页码: 9
作者:  Qiu, Jie;  Yuan, Chun-Mao;  Wen, Min;  Li, Ya-Nan;  Chen, Juan;  Jian, Jun-You;  Huang, Lie-Jun;  Gu, Wei;  Li, Yan-Mei;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(1093Kb)  |  收藏  |  浏览/下载：245/62  |  提交时间：2019/07/29
Parthenolide-thiazolidinedione hybrids  click chemistry  cytotoxic activities  
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
浏览  |  Adobe PDF(3047Kb)  |  收藏  |  浏览/下载：371/55  |  提交时间：2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)