| Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry | |
Qiu, Jie1,2,3; Yuan, Chun-Mao1,2,3; Wen, Min1,3; Li, Ya-Nan1,2,3; Chen, Juan1,2,3; Jian, Jun-You1,2,3; Huang, Lie-Jun1,2,3; Gu, Wei1,2,3 ; Li, Yan-Mei1,2,3; Hao, Xiao-Jiang1,2,3,4
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| 通讯作者 | Li, Yan-Mei(liyanmei518@hotmail.com) ; Hao, Xiao-Jiang(haoxj@mail.kib.ac.cn) |
| 2019-04-20 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| ISSN | 1028-6020 |
| 页码 | 9 |
| 摘要 | A series of novel parthenolide-thiazolidinedione hybrids have been synthesized via a click chemistry-mediated coupling between parthenolide and thiazolidinedione, and evaluated for their cytotoxic activities. The results indicated that all the hybrids showed moderate cytotoxic effects on human cancer cell lines, including human erythroleukemia cell line (HEL), prostate (PC3), and breast (MDA-MB-231) by MTT assay. In particular, compound VI-6 exhibited the best cytotoxic activities against the MDA-MB-231 cells with IC50 value of 2.07 mu M, which was about eight times more active than that of the original compound (PTL). These interesting results might be used to develop novel lead scaffolds for potential anticancer agents. [GRAPHICS] . |
| 关键词 | Parthenolide-thiazolidinedione hybrids click chemistry cytotoxic activities |
| DOI | 10.1080/10286020.2019.1597055 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000469744600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/67318 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, Yan-Mei; Hao, Xiao-Jiang |
| 作者单位 | 1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China 2.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China 3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Jie,Yuan, Chun-Mao,Wen, Min,et al. Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019:9. |
| APA | Qiu, Jie.,Yuan, Chun-Mao.,Wen, Min.,Li, Ya-Nan.,Chen, Juan.,...&Hao, Xiao-Jiang.(2019).Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9. |
| MLA | Qiu, Jie,et al."Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019):9. |
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| qiu2019.pdf（1093KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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