Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry
Qiu, Jie1,2,3; Yuan, Chun-Mao1,2,3; Wen, Min1,3; Li, Ya-Nan1,2,3; Chen, Juan1,2,3; Jian, Jun-You1,2,3; Huang, Lie-Jun1,2,3; Gu, Wei1,2,3; Li, Yan-Mei1,2,3; Hao, Xiao-Jiang1,2,3,4
Corresponding AuthorLi, Yan-Mei(liyanmei518@hotmail.com) ; Hao, Xiao-Jiang(haoxj@mail.kib.ac.cn)
2019-04-20
Source PublicationJOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
Pages9
AbstractA series of novel parthenolide-thiazolidinedione hybrids have been synthesized via a click chemistry-mediated coupling between parthenolide and thiazolidinedione, and evaluated for their cytotoxic activities. The results indicated that all the hybrids showed moderate cytotoxic effects on human cancer cell lines, including human erythroleukemia cell line (HEL), prostate (PC3), and breast (MDA-MB-231) by MTT assay. In particular, compound VI-6 exhibited the best cytotoxic activities against the MDA-MB-231 cells with IC50 value of 2.07 mu M, which was about eight times more active than that of the original compound (PTL). These interesting results might be used to develop novel lead scaffolds for potential anticancer agents. [GRAPHICS] .
KeywordParthenolide-thiazolidinedione hybrids click chemistry cytotoxic activities
DOI10.1080/10286020.2019.1597055
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000469744600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67318
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Yan-Mei; Hao, Xiao-Jiang
Affiliation1.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China
2.Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China
3.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Qiu, Jie,Yuan, Chun-Mao,Wen, Min,et al. Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019:9.
APA Qiu, Jie.,Yuan, Chun-Mao.,Wen, Min.,Li, Ya-Nan.,Chen, Juan.,...&Hao, Xiao-Jiang.(2019).Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9.
MLA Qiu, Jie,et al."Design, synthesis, and cytotoxic activities of novel hybrids of parthenolide and thiazolidinedione via click chemistry".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019):9.
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