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Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization 期刊论文
BIOMATERIALS, 2023, 卷号: 299, 页码: 122141
作者:  Zhou,Zhipeng;  Deng,Tuo;  Tao,Maixian;  Lin,Lisha;  Sun,Luyun;  Song,Xuemei;  Gao,Dongxiu;  Li,Jixing;  Wang,Zhongjuan;  Wang,Xingzi;  Li,Jinpeng;  Jiang,Zexiu;  Luo,Lan;  Yang,Lian;  Wu,Mingyi
浏览  |  Adobe PDF(24778Kb)  |  收藏  |  浏览/下载：56/17  |  提交时间：2024/07/22
Diabetic wound healing  Biomimetic hydrogels  Glycosaminoglycan  Inflammation suppression  Macrophage polarization  FOOT ULCERS  HUMAN SKIN  ACTIVATION  MANAGEMENT  RECEPTORS  DRESSINGS  EFFICACY  SAFETY  
Small-Molecule Drugs in Immunotherapy 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23, 期号: 13, 页码: 1341-1359
作者:  Hao,Xuanrun;  Chen,Zhongliang;  Li,Haining;  Wei,Minqin;  Zuo,Zhili;  Su,Qing
浏览  |  Adobe PDF(29350Kb)  |  收藏  |  浏览/下载：32/5  |  提交时间：2024/07/25
Cancer immunotherapy  inhibitors  Pd-1/Pd-L1 inhibitor  IDO inhibitor  STING agonists  ROR gamma t agonists  TGF  beta inhibitors  INDOLEAMINE 2,3-DIOXYGENASE  SIGNALING INHIBITOR  DENDRITIC CELLS  GROWTH  TUMOR  PATHWAY  PEMBROLIZUMAB  RECEPTORS  DISCOVERY  VADIMEZAN  
Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism 期刊论文
PHARMACEUTICAL BIOLOGY, 2022, 卷号: 60, 期号: 1, 页码: 810-824
作者:  Liu, Wei-Liang;  Wu, Bai-Fen;  Shang, Jian-Hua;  Wang, Xue-Feng;  Zhao, Yun-Li;  Huang, Ai-Xiang
浏览  |  Adobe PDF(4141Kb)  |  收藏  |  浏览/下载：61/12  |  提交时间：2024/04/30
Sedative-hypnotic  Cl- influx  GABA(A) receptors  GABA(A)-ergic systems  BLOOD-BRAIN-BARRIER  GABA(A) RECEPTORS  INSOMNIA  MODULATION  PHYSIOLOGY  FLAVONOIDS  TOXICITY  ANXIETY  NEURONS  DISEASE  
Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors 期刊论文
FRONTIERS IN NEUROSCIENCE, 2022, 卷号: 16, 页码: 1071068
作者:  Wang, Chen;  Zhu, Ming-Hao;  Sun, Na;  Shen, Wei;  Jiang, Ning;  Zhao, Qin-Shi;  Zhang, Yong-Xiang;  Huang, Yan;  Zhou, Wen-Xia
浏览  |  Adobe PDF(4973Kb)  |  收藏  |  浏览/下载：27/4  |  提交时间：2024/08/21
isorhynchophylline (PubChem CID  3037048)  corticosterone  long-term potentiation  chronic unpredictable mild stress  D-serine  NMDA receptors  CHRONIC MILD STRESS  DEPRESSION-LIKE BEHAVIORS  SYNAPTIC PLASTICITY  HIPPOCAMPAL PLASTICITY  DENTATE GYRUS  CORTICOSTERONE  MEMORY  BRAIN  RHYNCHOPHYLLINE  IMPROVES  
Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2021, 卷号: 90, 页码: 107405
作者:  Jiang,Xuan;  Li,Shuxiang;  Zhang,Hongbin;  Wang,Liang-Liang
浏览  |  Adobe PDF(6441Kb)  |  收藏  |  浏览/下载：177/25  |  提交时间：2022/04/02
mu-Opioid receptors (MOR)  Biased ligands  Molecular docking  Hip-hop pharmacophore  MD simulation  
A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution 期刊论文
MOLECULAR BIOLOGY AND EVOLUTION, 2021, 卷号: 38, 期号: 12, 页码: 5472-5479
作者:  Yang,Hui;  Yang,Songlin;  Fan,Fei;  Li,Yun;  Dai,Shaoxing;  Zhou,Xin;  Steiner,Cynthia C.;  Coppedge,Bretton;  Roos,Christian;  Cai,Xianghai;  Irwin,David M.;  Shi,Peng
收藏  |  浏览/下载：108/0  |  提交时间：2022/04/02
convergent evolution  bitter taste receptors  Tas2R16  human  white-faced saki  Pithecia pithecia  adaptive evolution  PHYLOGENETIC ANALYSIS  SENSITIVITY  DIVERSITY  SELECTION  TAS2R16  OPTIMIZATION  CONVERGENT  PLATFORM  DOCKING  FAMILY  
Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113872
作者:  Hou,Tao;  Xu,Fangfang;  Peng,Xingrong;  Zhou,Han;  Zhang,Xiuli;  Qiu,Minghua;  Wang,Jixia;  Liu,Yanfang;  Liang,Xinmiao
收藏  |  浏览/下载：115/0  |  提交时间：2022/04/02
Opioid receptors  Dynamic mass redistribution  Natural products  Antagonist  Selectivity  IDENTIFICATION  ANTAGONISTS  SUBSTANCES  NALOXEGOL  AGONISTS  SAFETY  MACA  
Chemical and biological comparison of different parts of Paeonia suffruticosa (Mudan) based on LCMS-IT-TOF and multi-evaluation in vitro 期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2020, 卷号: 144, 页码: 9
作者:  Pan, Yang;  Gao, Zhen;  Huang, Xiao-Yan;  Chen, Ji-Jun;  Geng, Chang-An
收藏  |  浏览/下载：277/0  |  提交时间：2020/03/24
Paeonia suffruticosa  Chemical profiles  LCMS-IT-TOF analyses  Biological comparison  Neurotransmitter receptors  Enzyme inhibition  
Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure-activity relationships 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3299-3306
作者:  Chen, Si-Yue;  Geng, Chang-An;  Ma, Yun-Bao;  Huang, Xiao-Yan;  Yang, Xiao-Tong;  Su, Li-Hua;  He, Xiao-Feng;  Li, Tian-Ze;  Deng, Zhen-Tao;  Gao, Zhen;  Zhang, Xue-Mei;  Chen, Ji-Jun
Adobe PDF(1837Kb)  |  收藏  |  浏览/下载：249/47  |  提交时间：2019/09/10
Gastrodia elata  Polybenzyls  Melatonin receptors  Structure-activity relationships  Docking study  
Antidepressant potential of Uncaria rhynchophylla and its active flavanol, catechin, targeting melatonin receptors 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 卷号: 232, 页码: 39-46
作者:  Geng, Chang-An;  Yang, Tong-Hua;  Huang, Xiao-Yan;  Ma, Yun-Bao;  Zhang, Xue-Mei;  Chen, Ji-Jun
Adobe PDF(3731Kb)  |  收藏  |  浏览/下载：265/54  |  提交时间：2019/06/24
Uncaria rhynchophylla  Catechin  Melatonin receptors  Metabolites  Antidepressant activity