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An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
作者:  Munikishore,Rachakunta;  Wang,Liang-Liang;  Zhang,Shuqun;  Zhao,Qin-Shi;  Zuo,Zhili
浏览  |  Adobe PDF(523Kb)  |  收藏  |  浏览/下载：137/32  |  提交时间：2022/04/02
Cathepsin L  small-molecule inhibitor  gram-scale synthesis  KGP94  cancer  FUNCTIONALIZED BENZOPHENONE  BIOLOGICAL EVALUATION  TUMOR PROGRESSION  CELL INVASION  EXPRESSION  ANALOGS  SUPPRESSION  DERIVATIVES  ACID  
An Approach for the Synthesis of Pyrazolo[1,5-a]pyrimidines via Cu(II)-Catalyzed [3+3] Annulation of Saturated Ketones with Aminopyrazoles 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 18, 页码: 12762-12771
作者:  Ren,Jian;  Ding,Shihua;  Li,Xiaonian;  Bi,Ran;  Zhao,Qinshi
浏览  |  Adobe PDF(1469Kb)  |  收藏  |  浏览/下载：197/34  |  提交时间：2022/04/02
BIOLOGICAL EVALUATION  REGIOSELECTIVE SYNTHESIS  CASCADE REACTIONS  FUNCTIONALIZATION  DEHYDROGENATION  DISCOVERY  POTENT  BOND  SAR  
Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 6
作者:  Wang, Xue-Quan;  Chen, Xue-Bing;  Ye, Ping-Ting;  Yang, Zhi-Xin;  Bai, Meng-Jiao;  Duan, Su-Yue;  Li, Yan;  Yang, Xiao-Dong
收藏  |  浏览/下载：274/0  |  提交时间：2020/03/18
3-Benzylcoumarin  Imidazolium salts  Biological evaluation  Cytotoxic activity  Structure-activity relationships  
Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 2, 页码: 7
作者:  Weng, Zhiying;  Xu, Guowei;  Chen, Dingyuan;  Yang, Yaqing;  Song, Gao;  Shen, Wen;  Zhang, Shuqun;  Wang, LiangLiang;  Yang, Weimin;  Zuo, Zhili
收藏  |  浏览/下载：229/0  |  提交时间：2020/03/18
Adenylyl cyclases  Homology modeling  Consensus scoring  Molecular dynamics simulation  Virtual screening  Biological evaluation  
Two New Compounds from Medicinal Insect Blaps japanensis and Their Biological Evaluation 期刊论文
NATURAL PRODUCT COMMUNICATIONS, 2018, 卷号: 13, 期号: 2, 页码: 149-151
作者:  Zheng, Tao;  Ming, Yan-Yong;  Tu, Zheng-Chao;  Xu, Fu Rong;  Cheng, Yong-Xian
收藏  |  浏览/下载：116/0  |  提交时间：2018/07/16
Blaps Japanensis  Insect  Pipajiains f And g  Biological Evaluation  
Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 14, 页码: 3911-3914
作者:  Wang, Li;  Yang, Jing;  Kong, Ling-Mei;  Deng, Jun;  Xiong, Zijun;  Huang, Jianping;  Luo, Jianping;  Yan, Yijun;  Hu, Yikao;  Li, Xiao-Nian;  Li, Yan;  Zhao, Yong;  Huang, Sheng-Xiong
浏览  |  Adobe PDF(1338Kb)  |  收藏  |  浏览/下载：342/94  |  提交时间：2017/10/23
Protein-kinase-c  Phorbol Esters  Biological Evaluation  Biosynthesis  (+)-phorbol  Analogs  Cancer  Seeds  
Phenolic derivatives from Blaps japanensis and their biological evaluation 期刊论文
FITOTERAPIA, 2017, 卷号: 120, 页码: 58-60
作者:  Zheng, Tao;  Yan, Yong-Ming;  Tu, Zheng-Chao;  Luo, Qi;  Xu, Fu-Rong;  Cheng, Yong-Xian
浏览  |  Adobe PDF(294Kb)  |  收藏  |  浏览/下载：279/87  |  提交时间：2017/10/23
Blaps Japanensis  Insect  Biological Evaluation  Phenolic Derivatives  
Bioactive compounds from the insect Aspongopus chinensis 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 22, 页码: 5164-5169
作者:  Shi, Yan-Ni;  Tu, Zheng-Chao;  Wang, Xin-Long;  Yan, Yong-Ming;  Fang, Ping;  Zuo, Zhi-Li;  Hou, Bo;  Yang, Tong-Hua;  Cheng, Yong-Xian;  Yang,TH (reprint author),First Peoples Hosp Yunnan Prov,Dept Hematol,Kunming 650032,Peoples R China.;  ynanblood@aliyun.com;  yxcheng@mail.kib.ac.cn
浏览  |  Adobe PDF(695Kb)  |  收藏  |  浏览/下载：399/148  |  提交时间：2015/01/20
Aspongopus Chinensis  Insects  Norepinephrine Derivatives  Sesquiterpenoids  Lactam  Biological Evaluation  
Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 卷号: 12, 期号: 43, 页码: 8764-8774
作者:  Lv, Jun-Jiang;  Wang, Ya-Feng;  Zhang, Jing-Min;  Yu, Shan;  Wang, Dong;  Zhu, Hong-Tao;  Cheng, Rong-Rong;  Yang, Chong-Ren;  Xu, Min;  Zhang, Ying-Jun;  Xu,M (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.;  minxu@mail.kib.ac.cn;  zhangyj@mail.kib.ac.cn
浏览  |  Adobe PDF(1935Kb)  |  收藏  |  浏览/下载：479/90  |  提交时间：2015/01/20
Constituents  Model  Aspongopus Chinensis  Insects  Norepinephrine Derivatives  Sesquiterpenoids  Lactam  Biological Evaluation  
Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius 期刊论文
ORGANIC LETTERS, 2013, 卷号: 15, 期号: 17, 页码: 4446-4449
作者:  Zhou, Min;  Zhang, Hai-Bo;  Wang, Wei-Guang;  Gong, Ning-Bo;  Zhan, Rui;  Li, Xiao-Nian;  Du, Xue;  Li, Li-Mei;  Li, Yan;  Lu, Yang;  Pu, Jian-Xin;  Sun, Han-Dong
浏览  |  Adobe PDF(792Kb)  |  收藏  |  浏览/下载：479/124  |  提交时间：2014/01/21
2+2 Cycloadditions  Biyouyanagin-a  Biological Evaluation  Incarvillea-sinensis  Revised Structure  Skeleton  Littoralisone  Alkaloids  Diterpene