| Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor | |
Wang, Li1,2,4; Yang, Jing1,2 ; Kong, Ling-Mei1,2; Deng, Jun1,2; Xiong, Zijun1,2,4; Huang, Jianping1,2; Luo, Jianping1,2; Yan, Yijun1,2; Hu, Yikao3; Li, Xiao-Nian1,2; Li, Yan1,2; Zhao, Yong3; Huang, Sheng-Xiong1,2
| |
| 2017-07-21 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 19期号:14页码:3911-3914 |
| 摘要 | Euphordracuroate5 A (1) and B (2), featuring tigliane diterpenoids with two new carbon skeletons, :Were characterized as metabolites of Euphorbia dracunculoides and semisynthetic products, respectively. Their structures were determined by spectroscopic analyses and X-ray. crystallog raphy. The respective biosynthetic and chemical formation 0 mechanisms for 1 and 2 from, a known tigliane 3 was proposed. The detailed decarbonization mechanism from 3, to 2 was further explored by O-18-labeling experiment. Compound 2 could inhibit Wnt pathway in a dose- and time-dependent manner. |
| 关键词 | Protein-kinase-c Phorbol Esters Biological Evaluation Biosynthesis (+)-phorbol Analogs Cancer Seeds |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/acs.orglett.7b01813 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000406356500057 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/54941 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Li,Yang, Jing,Kong, Ling-Mei,et al. Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor[J]. ORGANIC LETTERS,2017,19(14):3911-3914. |
| APA | Wang, Li.,Yang, Jing.,Kong, Ling-Mei.,Deng, Jun.,Xiong, Zijun.,...&Huang, Sheng-Xiong.(2017).Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor.ORGANIC LETTERS,19(14),3911-3914. |
| MLA | Wang, Li,et al."Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor".ORGANIC LETTERS 19.14(2017):3911-3914. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 44.pdf（1338KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论