Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor

doi:10.1021/acs.orglett.7b01813

	Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor
	Wang, Li 1,2,4; Yang, Jing1,2 ; Kong, Ling-Mei 1,2; Deng, Jun 1,2; Xiong, Zijun 1,2,4; Huang, Jianping 1,2; Luo, Jianping 1,2; Yan, Yijun 1,2; Hu, Yikao 3; Li, Xiao-Nian 1,2; Li, Yan1,2 ; Zhao, Yong 3; Huang, Sheng-Xiong1,2
	2017-07-21
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	19 期号:14 页码:3911-3914
摘要	Euphordracuroate5 A (1) and B (2), featuring tigliane diterpenoids with two new carbon skeletons, :Were characterized as metabolites of Euphorbia dracunculoides and semisynthetic products, respectively. Their structures were determined by spectroscopic analyses and X-ray. crystallog raphy. The respective biosynthetic and chemical formation 0 mechanisms for 1 and 2 from, a known tigliane 3 was proposed. The detailed decarbonization mechanism from 3, to 2 was further explored by O-18-labeling experiment. Compound 2 could inhibit Wnt pathway in a dose- and time-dependent manner.
关键词	Protein-kinase-c Phorbol Esters Biological Evaluation Biosynthesis (+)-phorbol Analogs Cancer Seeds
学科领域	Chemistry, Organic
DOI	10.1021/acs.orglett.7b01813
收录类别	SCI
语种	英语
WOS记录号	WOS:000406356500057
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/54941
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Li,Yang, Jing,Kong, Ling-Mei,et al. Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor[J]. ORGANIC LETTERS,2017,19(14):3911-3914.
APA	Wang, Li.,Yang, Jing.,Kong, Ling-Mei.,Deng, Jun.,Xiong, Zijun.,...&Huang, Sheng-Xiong.(2017).Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor.ORGANIC LETTERS,19(14),3911-3914.
MLA	Wang, Li,et al."Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor".ORGANIC LETTERS 19.14(2017):3911-3914.

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