Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor
Wang, Li1,2,4; Yang, Jing1,2; Kong, Ling-Mei1,2; Deng, Jun1,2; Xiong, Zijun1,2,4; Huang, Jianping1,2; Luo, Jianping1,2; Yan, Yijun1,2; Hu, Yikao3; Li, Xiao-Nian1,2; Li, Yan1,2; Zhao, Yong3; Huang, Sheng-Xiong1,2
2017-07-21
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume19Issue:14Pages:3911-3914
AbstractEuphordracuroate5 A (1) and B (2), featuring tigliane diterpenoids with two new carbon skeletons, :Were characterized as metabolites of Euphorbia dracunculoides and semisynthetic products, respectively. Their structures were determined by spectroscopic analyses and X-ray. crystallog raphy. The respective biosynthetic and chemical formation 0 mechanisms for 1 and 2 from, a known tigliane 3 was proposed. The detailed decarbonization mechanism from 3, to 2 was further explored by O-18-labeling experiment. Compound 2 could inhibit Wnt pathway in a dose- and time-dependent manner.
KeywordProtein-kinase-c Phorbol Esters Biological Evaluation Biosynthesis (+)-phorbol Analogs Cancer Seeds
Subject AreaChemistry, Organic
DOI10.1021/acs.orglett.7b01813
Indexed BySCI
Language英语
WOS IDWOS:000406356500057
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/54941
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Wang, Li,Yang, Jing,Kong, Ling-Mei,et al. Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor[J]. ORGANIC LETTERS,2017,19(14):3911-3914.
APA Wang, Li.,Yang, Jing.,Kong, Ling-Mei.,Deng, Jun.,Xiong, Zijun.,...&Huang, Sheng-Xiong.(2017).Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor.ORGANIC LETTERS,19(14),3911-3914.
MLA Wang, Li,et al."Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor".ORGANIC LETTERS 19.14(2017):3911-3914.
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