Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts

doi:10.1016/j.bmcl.2019.126896

	Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts
	Wang, Xue-Quan 1; Chen, Xue-Bing 1; Ye, Ping-Ting 1; Yang, Zhi-Xin 1; Bai, Meng-Jiao 1; Duan, Su-Yue 1; Li, Yan3 ; Yang, Xiao-Dong 2
通讯作者	Li, Yan(liyanb@mail.kib.ac.cn) ; Yang, Xiao-Dong(xdyang@ynu.edu.cn)
	2020-02-15
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN	0960-894X
卷号	30 期号:4 页码:6
摘要	A series of novel 3-benzylcoumarin-imidazolium salts were prepared and evaluated in vitro against a panel of human tumor cell lines. The results showed that the existence of 5,6-dimethyl-benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl group were vital for modulating cytotoxic activity. Notably, compound 38 was found to be the most potent derivative with IC50 values of 2.04-4.51 mu M against five human tumor cell lines, while compound 34 were more selective to SW-480 cell lines with IC50 value 40.0-fold lower than DDP. Mechanism of action studies indicated that compound 38 can cause the G0/G1 phase cell cycle arrest and apoptosis in SMMC-7721 cell lines.
关键词	3-Benzylcoumarin Imidazolium salts Biological evaluation Cytotoxic activity Structure-activity relationships
DOI	10.1016/j.bmcl.2019.126896
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000507987200012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/70647
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Yan; Yang, Xiao-Dong
作者单位	1.Honghe Univ, Sch Sci, Key Lab Nat Pharmaceut & Chem Biol Yunnan Prov, Mengzi 661100, Yunnan, Peoples R China 2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xue-Quan,Chen, Xue-Bing,Ye, Ping-Ting,et al. Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2020,30(4):6.
APA	Wang, Xue-Quan.,Chen, Xue-Bing.,Ye, Ping-Ting.,Yang, Zhi-Xin.,Bai, Meng-Jiao.,...&Yang, Xiao-Dong.(2020).Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,30(4),6.
MLA	Wang, Xue-Quan,et al."Synthesis and biological evaluation of novel 3-benzylcoumarin-imidazolium salts".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 30.4(2020):6.