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Small-Molecule Drugs in Immunotherapy 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23, 期号: 13, 页码: 1341-1359
作者:  Hao,Xuanrun;  Chen,Zhongliang;  Li,Haining;  Wei,Minqin;  Zuo,Zhili;  Su,Qing
浏览  |  Adobe PDF(29350Kb)  |  收藏  |  浏览/下载：35/5  |  提交时间：2024/07/25
Cancer immunotherapy  inhibitors  Pd-1/Pd-L1 inhibitor  IDO inhibitor  STING agonists  ROR gamma t agonists  TGF  beta inhibitors  INDOLEAMINE 2,3-DIOXYGENASE  SIGNALING INHIBITOR  DENDRITIC CELLS  GROWTH  TUMOR  PATHWAY  PEMBROLIZUMAB  RECEPTORS  DISCOVERY  VADIMEZAN  
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120
作者:  Zhou,Gui-Feng;  Tang,Jing;  Ma,Yuan-Lin;  Fu,Xian;  Liu,Jun-Yan;  Yang,Ren-Zhi;  Zhang,Hong-Sheng;  Cai,Xiang-Hai;  Wang,Jing-Wen;  Xie,Xiao-Yong;  Song,Li;  Luo,Biao;  Chen,Jian;  Chen,Long;  Deng,Xiao-Juan;  Chen,Guo-Jun
浏览  |  Adobe PDF(6685Kb)  |  收藏  |  浏览/下载：112/18  |  提交时间：2024/05/09
conophylline  ARL6IP1  5'UTR  FXR1  BACE1 translation  AMYLOID PRECURSOR PROTEIN  A-BETA  TRANSGENIC MICE  MOUSE MODEL  NEURODEGENERATION  EXPRESSION  REDUCTION  MEMBRANE  MEMORY  ER  
The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-kappa B Signalling 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 19, 页码: 11195
作者:  Ling, Jiawei;  Chan, Chung-Lap;  Ho, Chi-Yan;  Gao, Xun;  Tsang, Sin-Man;  Leung, Ping-Chung;  Hu, Jiang-Miao;  Wong, Chun-Kwok
浏览  |  Adobe PDF(3779Kb)  |  收藏  |  浏览/下载：74/14  |  提交时间：2024/04/30
dry eye disease  Dendrobium  aquaporin  scopolamine  human cornea keratocytes  TNF-ALPHA  ACTIVATION  CLASSIFICATION  INFLAMMATION  DEFINITION  IL-1-BETA  APOPTOSIS  PATHWAYS  STRESS  MMP-9  
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 2, 页码: 350-367
作者:  Yang, Xiao-Tong;  Li, Tian-Ze;  Geng, Chang-An;  Liu, Pei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1348Kb)  |  收藏  |  浏览/下载：74/15  |  提交时间：2024/04/30
(20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol  alpha-glucosidase inhibitors  PTP1B inhibitors  Enzyme kinetics  TYROSINE-PHOSPHATASE 1B  DIABETES-MELLITUS  EPIDEMIOLOGY  
Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort 期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 12, 期号: 34, 页码: 11438-11446
作者:  Guo,Yi;  Huang,Fang;  Sun,Weiguang;  Zhou,Yuan;  Chen,Chunmei;  Qi,Changxing;  Yang,Jing;  Li,Xiao-Nian;  Luo,Zengwei;  Zhu,Hucheng;  Wang,Xiaochuan;  Zhang,Yonghui
收藏  |  浏览/下载：193/0  |  提交时间：2022/04/02
AMYLOID-BETA  NEUROFIBRILLARY DEGENERATION  HYPERFORIN  NEUROTOXICITY  PATHOGENESIS  INHIBITION  BACE1  DRUG  TAU  
Bitter Melon and Diabetes Mellitus 期刊论文
FOOD REVIEWS INTERNATIONAL, 2021
作者:  Gao,Ya;  Li,Xian;  Huang,Yanjie;  Chen,Jianchao;  Qiu,Minghua
收藏  |  浏览/下载：104/0  |  提交时间：2022/04/02
Bitter melon  diabetes mellitus  crude extracts  phyto-metabolites  hypoglycemic mechanism  MOMORDICA-CHARANTIA L.  11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1  ALPHA-GLUCOSIDASE INHIBITION  INSULIN-RESISTANCE  ANTIDIABETIC ACTIVITIES  GUT MICROBIOTA  STRUCTURAL-CHARACTERIZATION  PHENOLIC-COMPOUNDS  OXIDATIVE STRESS  PROTEIN-KINASE  
Isolation and identification of belamcandaoids A-N from Belamcanda chinensis seeds and their inhibition on extracellular matrix in TGF-beta 1 induced kidney proximal tubular cells 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 105067
作者:  Song,Ying-Ying;  Jiang,Jian-Bing;  Yan,Yong-Ming;  Cheng,Yong-Xian
浏览  |  Adobe PDF(4755Kb)  |  收藏  |  浏览/下载：175/57  |  提交时间：2022/04/02
Belamcanda chinensis  Triterpenoids  TGF-beta 1  Kidney proximal tubular cells  TGF-BETA  TRITERPENOIDS  CONSTITUENTS  
Patterns of phylogenetic beta diversity measured at deep evolutionary histories across geographical and ecological spaces for angiosperms in China 期刊论文
JOURNAL OF BIOGEOGRAPHY, 2021, 卷号: 48, 期号: 4, 页码: 773-784
作者:  Qian,Hong;  Jin,Yi;  Leprieur,Fabien;  Wang,Xianli;  Deng,Tao
浏览  |  Adobe PDF(1074Kb)  |  收藏  |  浏览/下载：171/52  |  提交时间：2022/04/02
Chinese flora  environmental gradient  flowering plants  latitudinal gradient  phylogenetic beta diversity  1ST FOSSIL RECORD  VASCULAR PLANTS  SPECIES RICHNESS  ASIAN MONSOON  COMMUNITY STRUCTURE  NICHE CONSERVATISM  EASTERN ASIA  SCALE  TERRESTRIAL  ENVIRONMENT  
1,4-beta-D-Glucomannan from Dendrobium officinale Activates NF-kappa B via TLR4 to Regulate the Immune Response 期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 10, 页码: 15
作者:  Huang, Yan-Ping;  He, Tao-Bin;  Cuan, Xian-Dan;  Wang, Xuan-Jun;  Hu, Jiang-Miao;  Sheng, Jun
收藏  |  浏览/下载：89/0  |  提交时间：2018/12/27
Dendrobium officinale  1,4-beta-D-glucomannan  thermal stability  NF-kappa B  TLR4  
Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1336Kb)  |  收藏  |  浏览/下载：368/91  |  提交时间：2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar