Bitter Melon and Diabetes Mellitus

doi:10.1080/87559129.2021.1923733

KIB OpenIR

	Bitter Melon and Diabetes Mellitus
	Gao,Ya ; Li,Xian ; Huang,Yanjie ; Chen,Jianchao ; Qiu,Minghua
	2021
发表期刊	FOOD REVIEWS INTERNATIONAL
ISSN	8755-9129
摘要	Bitter melon (Momordica charantia) has traditionally been used in the management of diabetes in many countries and territories. However, standardized information on the use of this vegetable as an antidiabetic drug is still very limited. Many animal studies and clinical trials have showed the remarkable effect of bitter melon on diabetes. The research results showed that bitter melon could enhance insulin sensitivity, repair damaged pancreas islet beta-cells and stimulate insulin secretion. What's more, bitter melon could reduce hyperglycemia by regulating intestinal flora, inhibiting glucosidase and amylase, scavenging free radicals, enhancing the activity of AMP-activated protein kinase (AMPK) and increasing expression of peroxisome proliferator-activated receptors (PPARs). In addition, it could also act as the glucagon-like peptide 1 receptor (GLP-1 R) agonist and the 11-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor to exert hypoglycemic effects. Therefore, we will discuss the hypoglycemic mechanisms of crude extracts and different phyto-metabolites derived from bitter melon in the paper.
关键词	Bitter melon diabetes mellitus crude extracts phyto-metabolites hypoglycemic mechanism MOMORDICA-CHARANTIA L. 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 ALPHA-GLUCOSIDASE INHIBITION INSULIN-RESISTANCE ANTIDIABETIC ACTIVITIES GUT MICROBIOTA STRUCTURAL-CHARACTERIZATION PHENOLIC-COMPOUNDS OXIDATIVE STRESS PROTEIN-KINASE
DOI	10.1080/87559129.2021.1923733
WOS记录号	WOS:000702674200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73341
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Gao,Ya,Li,Xian,Huang,Yanjie,et al. Bitter Melon and Diabetes Mellitus[J]. FOOD REVIEWS INTERNATIONAL,2021.
APA	Gao,Ya,Li,Xian,Huang,Yanjie,Chen,Jianchao,&Qiu,Minghua.(2021).Bitter Melon and Diabetes Mellitus.FOOD REVIEWS INTERNATIONAL.
MLA	Gao,Ya,et al."Bitter Melon and Diabetes Mellitus".FOOD REVIEWS INTERNATIONAL (2021).