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Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress 期刊论文
PHYTOMEDICINE, 2023, 卷号: 112, 页码: 154720
作者:  Niu,Zhenpeng;  Tang,Guihua;  Wang,Xuenan;  Yang,Xu;  Zhao,Yueqin;  Wang,Yinyuan;  Liu,Qin;  Zhang,Fan;  Zhao,Yuhan;  Ding,Xiao;  Hao,Xiaojiang
浏览  |  Adobe PDF(11543Kb)  |  收藏  |  浏览/下载：12/2  |  提交时间：2024/07/17
Lysosomal biogenesis  Autophagy  TFEB  TFE3  ER stress  IVDD  STAT3  TFE3  
Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy 期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2023, 卷号: 21, 期号: 3, 页码: 514-519
作者:  Yan,Ying;  Ran,Xiaoqian;  Wang,Dan;  Zhang,Xiong;  Peng,Mingyou;  Yan,Xiaoyan;  Tang,Lei;  Liang,Hong;  Qin,Xujie;  Di,Ying-Tong;  Luo,Rongcan;  Hao,Xiao-Jiang;  Yao,Yong-Gang
浏览  |  Adobe PDF(1471Kb)  |  收藏  |  浏览/下载：25/7  |  提交时间：2024/07/25
UBIQUITIN-PROTEASOME SYSTEM  ALZHEIMERS-DISEASE  CONSTITUENTS  LIMONOIDS  TFEB  NEURODEGENERATION  
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217) 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1487
作者:  Li,Sheng;  Han,Ling-Ling;  Huang,Ke-Pu;  Ma,Ye-Han;  Guo,Ling-Li;  Guo,Yarong;  Ran,Xiaoqian;  Yao,Yong-Gang;  Hao,Xiao-Jiang;  Luo,Rongcan;  Zhang,Yu
浏览  |  Adobe PDF(5266Kb)  |  收藏  |  浏览/下载：43/13  |  提交时间：2024/05/09
Tabernaemontana crassa  monoterpenoid indole alkaloids  A beta 42  phospho-tau (Thr217)  Alzheimer's disease  ALZHEIMERS-DISEASE  BISINDOLE ALKALOIDS  CDK5  GEMFIBROZIL  PREVENTION  ALGORITHM  AUTOPHAGY  MODELS  PLANTS  MOUSE  
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1088
作者:  Yan,Ying;  Zhou,Qi;  Ran,Xiaoqian;  Lu,Qingyun;  Zhang,Cuishan;  Peng,Mingyou;  Tang,Lei;  Luo,Rongcan;  Di,Yingtong;  Hao,Xiaojiang
浏览  |  Adobe PDF(11343Kb)  |  收藏  |  浏览/下载：57/15  |  提交时间：2024/05/09
euphjatrophane  Euphorbia peplus  jatrophane diterpenoid  autophagy  Tau pathology  UBIQUITIN-PROTEASOME SYSTEM  MULTIDRUG-RESISTANCE  BIOLOGICAL-ACTIVITY  ALZHEIMERS-DISEASE  MODULATORS  CELLS  
Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway 期刊论文
HELIYON, 2023, 卷号: 9, 期号: 2, 页码: e13691
作者:  Ran,Xiaoqian;  Lu,Qing-Yun;  Li,Ying-Yao;  Pu,Xue-Xue;  Guo,Yarong;  Yuan,Ming-Rui;  Guan,Shi-Peng;  Sun,Mao;  Jiao,Lijin;  Yao,Yong-Gang;  Di,Ying-Tong;  Hao,Xiao-Jiang;  Luo,Rongcan
浏览  |  Adobe PDF(10283Kb)  |  收藏  |  浏览/下载：14/5  |  提交时间：2024/07/30
Euphorbia peplus L  Euphorbiaceae  Ent-abietane diterpenoid  Euphejolkinolide A  Autophagy-lysosomal pathway  ALZHEIMERS-DISEASE  TAU PATHOLOGY  NEURODEGENERATION  DITERPENOIDS  INHIBITION  MECHANISMS  APOPTOSIS  CELASTROL  PROTEIN  SYSTEM  
Iridoid glycosides from Morinda officinalis induce lysosomal biogenesis and promote autophagic flux to attenuate oxidative stress 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023
作者:  Wang,Yin-Yuan;  Ni,Jian-Cheng;  Zhao,Yue-Qin;  Yang,Xu;  Niu,Zhen-Peng;  Yang,Xing-Zhi;  Dong,Xian-Xiang;  Zhao,Yu-Han;  Hao,Xiao-Jiang;  Ding,Xiao
浏览  |  Adobe PDF(1997Kb)  |  收藏  |  浏览/下载：8/1  |  提交时间：2024/07/31
Iridoid glycosides  Morinda officinalis  lysosomal biogenesis  TFEB/TFE3  antioxidant activity  TRANSCRIPTIONAL CONTROL  TFEB  PHOSPHORYLATION  REVEALS  PATHWAY