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New steroids and sesquiterpene from Turraea pubescens 期刊论文
FITOTERAPIA, 2013, 卷号: 90, 页码: 119-125
作者:  Yuan, Chun-Mao;  Tang, Gui-Hua;  Wang, Xiao-Ying;  Zhang, Yu;  Cao, Ming-Ming;  Li, Xiao-Hui;  Li, Yan;  Li, Shun-Lin;  Di, Ying-Tong;  He, Hong-Ping;  Hao, Xiao-Jiang;  Hua, Hui-Ming
Adobe PDF(899Kb)  |  收藏  |  浏览/下载：500/264  |  提交时间：2014/01/13
Turraea Pubescens  Meliaceae  Steroids  Sesquiterpene  Anti-inflammatory  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：682/104  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis 期刊论文
ARCHIVES OF PHARMACAL RESEARCH, 2013, 卷号: 36, 期号: 9, 页码: 1084-1089
作者:  Cheng, Jin Tang;  Han, Ya Qiong;  He, Juan;  Wu, Xing De;  Dong, Liao Bin;  Peng, Li Yan;  Li, Yan;  Zhao, Qin Shi
Adobe PDF(292Kb)  |  收藏  |  浏览/下载：223/81  |  提交时间：2013/10/16
Aquilaria Sinensis  Tirucallane Triterpenoids  Aquilacallanes A-b  Cytotoxic Activity  
New eudesmenoic acid methyl esters from the seed oil of Jatropha curcas 期刊论文
FITOTERAPIA, 2013, 卷号: 89, 页码: 278-284
作者:  Yang, Yuan-Feng;  Liu, Jie-Qing;  Li, Zhong-Rong;  Li, Yan;  Qiu, Ming-Hua
Adobe PDF(747Kb)  |  收藏  |  浏览/下载：300/77  |  提交时间：2013/10/16
Jatropha Curcas  Euphorbiaceae  Sesquiterpenoid  Germacranolide  Eudesmanolide  Cytotoxicity  
Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with beta-Catenin/TCF4 Interaction in Colorectal Cancer Cells 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 7, 页码: e68525
作者:  Li, Xingyao;  Pu, Jianxin;  Jiang, Shiyou;  Su, Jia;  Kong, Lingmei;  Mao, Bingyu;  Sun, Handong;  Li, Yan
Adobe PDF(1775Kb)  |  收藏  |  浏览/下载：557/93  |  提交时间：2013/10/16
Beta-catenin  Colon-cancer  Response Element  Activation  Expression  Pathway  Complex  Growth  Apc  Antagonists  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：264/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Cytotoxic Cycloartane Triterpenes of the Traditional Chinese Medicine "Shengma" (Cimicifuga dahurica) 期刊论文
PLANTA MEDICA, 2013, 卷号: 79, 期号: 1, 页码: 60-69
作者:  Nian, Yin;  Wang, Hai-Yan;  Zhou, Lin;  Su, Jia;  Li, Yan;  Qiu, Ming-Hua
Adobe PDF(185Kb)  |  收藏  |  浏览/下载：657/77  |  提交时间：2013/03/18
Ranunculaceae  Cimicifuga Dahurica  Cycloartane Triterpenes  Cytotoxicity  Structure-activity Relationships  
Bioactive phenolics and terpenoids from Manglietia insignis 期刊论文
FITOTERAPIA, 2013, 卷号: 84, 页码: 58-63
作者:  Shang, Shan-Zhai;  Kong, Ling-Mei;  Yang, Li-Ping;  Jiang, Jing;  Huang, Jin;  Zhang, Hai-Bo;  Shi, Yi-Ming;  Zhao, Wei;  Li, Hong-Lin;  Luo, Huai-Rong;  Li, Yan;  Xiao, Wei-Lie;  Sun, Han-Dong
Adobe PDF(340Kb)  |  收藏  |  浏览/下载：495/128  |  提交时间：2013/07/24
Manglietia Insignis  Magnoliaceae  Neolignan  Sesquiterpene  Bioactivity