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The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 977-989
作者:  Yi, Shou-pu;  Kong, Qing-hong;  Li, Yu-lei;  Pan, Chen-ling;  Yu, Jie;  Cui, Ben-qiang;  Wang, Ying-fei;  Wang, Guan-lin;  Zhou, Pei-lan;  Wang, Li-li;  Gong, Ze-hui;  Su, Rui-bin;  Shen, Yue-hai;  Yu, Gang;  Chang, Kwen-jen
Adobe PDF(854Kb)  |  收藏  |  浏览/下载：359/72  |  提交时间：2017/08/29
Opioid Receptor  Mixed Agonist  Dpi-125  Analgesia  Respiratory Depression  Addiction  
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 1806
作者:  Xia, En-Hua;  Yang, Da-Rong;  Jiang, Jian-Jun;  Zhang, Qun-Jie;  Liu, Yuan;  Liu, Yun-Long;  Zhang, Yun;  Zhang, Hai-Bin;  Shi, Cong;  Tong, Yan;  Kim, Changhoon;  Chen, Hua;  Peng, Yan-Qiong;  Yu, Yue;  Zhang, Wei;  Eichler, Evan E.;  Gao, Li-Zhi
Adobe PDF(5215Kb)  |  收藏  |  浏览/下载：325/60  |  提交时间：2017/07/10
Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production 期刊论文
MOLECULAR CARCINOGENESIS, 2017, 卷号: 56, 期号: 5, 页码: 1414-1426
作者:  Yu, Xinfang;  Li, Wei;  Deng, Qipan;  You, Shuo;  Liu, Haidan;  Peng, Songling;  Liu, Xiaolan;  Lu, Jingchen;  Luo, Xiangjian;  Yang, Lifang;  Tang, Min;  Weng, Xinxian;  Yi, Wei;  Liu, Wenbin;  Wu, Shengqi;  Ding, Zhihui;  Feng, Tao;  Zhou, Jian;  Fan, Jia;  Bode, Ann M.;  Dong, Zigang;  Liu, Jikai;  Cao, Ya
Adobe PDF(6365Kb)  |  收藏  |  浏览/下载：348/104  |  提交时间：2017/06/30
Angiogenesis  Breast Cancer  Egfr  Neoalbaconol  Vegf  
Comparative QSAR studies using HQSAR, CoMFA, and CoMSIA methods on cyclic sulfone hydroxyethylamines as BACE1 inhibitors 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 67, 期号: 1, 页码: 38-47
作者:  Zhang, Shuqun;  Lin, Zichun;  Pu, Yinglan;  Zhang, Yunqin;  Zhang, Li;  Zuo, Zhili
Adobe PDF(1591Kb)  |  收藏  |  浏览/下载：320/65  |  提交时间：2017/05/19
Bace1  Ad  Hqsar  Comfa  Comsia  
A novel cycloartane triterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells 期刊论文
ONCOLOGY REPORTS, 2017, 卷号: 37, 期号: 4, 页码: 2079-2086
作者:  Dai, Xiaoli;  Liu, Jing;  Nian, Yin;  Qiu, Ming-Hua;  Luo, Ying;  Zhang, Jihong
Adobe PDF(1057Kb)  |  收藏  |  浏览/下载：228/52  |  提交时间：2017/06/01
Cimicifuga  Apoptosis  Autophagy  Colon Cancer Cells  
Ir-Catalyzed Asymmetric Total Synthesis of (-)-Communesin F 期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 卷号: 139, 期号: 9, 页码: 3364-3367
作者:  Liang, Xiao;  Zhang, Tian-Yuan;  Zeng, Xue-Yi;  Zheng, Yu;  Wei, Kun;  Yang, Yu-Rong
Adobe PDF(1350Kb)  |  收藏  |  浏览/下载：236/62  |  提交时间：2017/05/19
The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 4, 页码: 926-936
作者:  Sun, Xiaoyan;  Wang, Weiguang;  Chen, Jiao;  Cai, Xueting;  Yang, Jie;  Yang, Yang;  Yan, Huaijiang;  Cheng, Xiaolan;  Ye, Juan;  Lu, Wuguang;  Hu, Chunping;  Sun, Handong;  Pu, Jianxin;  Cao, Peng
Adobe PDF(1370Kb)  |  收藏  |  浏览/下载：457/208  |  提交时间：2017/02/28
Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 期号: 0, 页码: 42176
作者:  Li, Mingyue;  Song, Li-Hua;  Yue, Grace Gar-Lee;  Lee, Julia Kin-Ming;  Zhao, Li-Mei;  Li, Lin;  Zhou, Xunian;  Tsui, Stephen Kwok-Wing;  Ng, Simon Siu-Man;  Fung, Kwok-Pui;  Tan, Ning-Hua;  Lau, Clara Bik-San
Adobe PDF(3294Kb)  |  收藏  |  浏览/下载：237/46  |  提交时间：2017/04/17
Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay 期刊论文
MOLECULAR BIOSYSTEMS, 2017, 卷号: 13, 期号: 2, 页码: 363-370
作者:  Pu, Yinglan;  Zhang, Shuqun;  Chang, Zhe;  Zhang, Yunqin;  Wang, Dong;  Zhang, Li;  Li, Yan;  Zuo, Zhili
Adobe PDF(972Kb)  |  收藏  |  浏览/下载：701/124  |  提交时间：2017/05/19
Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 2, 页码: 2681-2693
作者:  Cheng, Xin;  Liu, Yong-Qiang;  Wang, Gui-Zhen;  Yang, Li-Na;  Lu, Yong-Zhi;  Li, Xin-Chun;  Zhou, Bo;  Qu, Li-Wei;  Wang, Xiao-Lu;  Cheng, Yong-Xian;  Liu, Jinsong;  Tao, Sheng-Ce;  Zhou, Guang-Biao
Adobe PDF(7649Kb)  |  收藏  |  浏览/下载：186/23  |  提交时间：2017/04/18
Proteome Microarray  6-o-angeloylplenolin  Stat3 Inhibitor  Skp2  Lung Cancer