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The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity
Xia, En-Hua1,2,3; Yang, Da-Rong4; Jiang, Jian-Jun1,2; Zhang, Qun-Jie1,5; Liu, Yuan1,2; Liu, Yun-Long1; Zhang, Yun1; Zhang, Hai-Bin1; Shi, Cong1,3; Tong, Yan1; Kim, Changhoon6; Chen, Hua7; Peng, Yan-Qiong4; Yu, Yue6; Zhang, Wei6; Eichler, Evan E.8,9; Gao, Li-Zhi1,2
2017-05-11
Source PublicationSCIENTIFIC REPORTS
Volume7Pages:1806
AbstractTo understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the -116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred -38 million years ago in concert with the uplift of the plateau. We also observe massive removal of thousands of genes related to the transport process and energy metabolism. O. sinensis displays considerable lineage-specific expansion of gene families functionally enriched in the adaptability of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection. We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its highland adaptation. Resequencing and analyzing 31 whole genomes of O. sinensis, representing nearly all of its geographic range, exhibits latitude-based population divergence and nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau.
DOI10.1038/s41598-017-01869-z
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000400959000073
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/51238
Collection中国西南野生生物种质资源库
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Plant Germplasm & Genom Ctr, Germplasm Bank Wild Species Southwestern China, Kunming 650204, Peoples R China
2.South China Agr Univ, Inst Genom & Bioinformat, Guangzhou 510642, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China
5.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Guangdong, Peoples R China
6.Marcogene Inc, Seoul 08511, South Korea
7.Chinese Acad Sci, Beijing Inst Genom, Ctr Computat Genom, Beijing 100101, Peoples R China
8.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
9.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
Recommended Citation
GB/T 7714
Xia, En-Hua,Yang, Da-Rong,Jiang, Jian-Jun,et al. The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity[J]. SCIENTIFIC REPORTS,2017,7:1806.
APA Xia, En-Hua.,Yang, Da-Rong.,Jiang, Jian-Jun.,Zhang, Qun-Jie.,Liu, Yuan.,...&Gao, Li-Zhi.(2017).The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity.SCIENTIFIC REPORTS,7,1806.
MLA Xia, En-Hua,et al."The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity".SCIENTIFIC REPORTS 7(2017):1806.
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