The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity

doi:10.1038/s41598-017-01869-z

	The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity
	Xia, En-Hua1,2,3 ; Yang, Da-Rong 4; Jiang, Jian-Jun 1,2; Zhang, Qun-Jie 1,5; Liu, Yuan1,2 ; Liu, Yun-Long 1; Zhang, Yun 1; Zhang, Hai-Bin 1; Shi, Cong 1,3; Tong, Yan 1; Kim, Changhoon 6; Chen, Hua 7; Peng, Yan-Qiong 4; Yu, Yue 6; Zhang, Wei 6; Eichler, Evan E.8,9; Gao, Li-Zhi1,2
	2017-05-11
发表期刊	SCIENTIFIC REPORTS
卷号	7 页码:1806
摘要	To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the -116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred -38 million years ago in concert with the uplift of the plateau. We also observe massive removal of thousands of genes related to the transport process and energy metabolism. O. sinensis displays considerable lineage-specific expansion of gene families functionally enriched in the adaptability of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection. We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its highland adaptation. Resequencing and analyzing 31 whole genomes of O. sinensis, representing nearly all of its geographic range, exhibits latitude-based population divergence and nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau.
DOI	10.1038/s41598-017-01869-z
收录类别	SCI
语种	英语
WOS记录号	WOS:000400959000073
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/51238
专题	中国西南野生生物种质资源库
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Plant Germplasm & Genom Ctr, Germplasm Bank Wild Species Southwestern China, Kunming 650204, Peoples R China 2.South China Agr Univ, Inst Genom & Bioinformat, Guangzhou 510642, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 5.Guangdong Acad Agr Sci, Agrobiol Gene Res Ctr, Guangzhou 510640, Guangdong, Peoples R China 6.Marcogene Inc, Seoul 08511, South Korea 7.Chinese Acad Sci, Beijing Inst Genom, Ctr Computat Genom, Beijing 100101, Peoples R China 8.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA 9.Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA
推荐引用方式 GB/T 7714	Xia, En-Hua,Yang, Da-Rong,Jiang, Jian-Jun,et al. The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity[J]. SCIENTIFIC REPORTS,2017,7:1806.
APA	Xia, En-Hua.,Yang, Da-Rong.,Jiang, Jian-Jun.,Zhang, Qun-Jie.,Liu, Yuan.,...&Gao, Li-Zhi.(2017).The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity.SCIENTIFIC REPORTS,7,1806.
MLA	Xia, En-Hua,et al."The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity".SCIENTIFIC REPORTS 7(2017):1806.

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