Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species
Li, Mingyue1,2; Song, Li-Hua3; Yue, Grace Gar-Lee2,4; Lee, Julia Kin-Ming2,4; Zhao, Li-Mei5; Li, Lin6; Zhou, Xunian1,2; Tsui, Stephen Kwok-Wing1; Ng, Simon Siu-Man6; Fung, Kwok-Pui1,2,4; Tan, Ning-Hua3,5; Lau, Clara Bik-San2,4
2017-02-09
Source PublicationSCIENTIFIC REPORTS
Volume7Issue:0Pages:42176
AbstractColorectal cancer (CRC) is the third most prevalent cancer and the third highest cancer-related mortality in the United States. Bigelovin, a sesquiterpene lactone isolated from Inula helianthus aquatica, has been proven to induce apoptosis and exhibit anti-inflammatory and anti-angiogenic activities. However, the effects of bigelovin on CRC and underlying mechanisms have not been explored. The present study demonstrated that bigelovin exhibited potent anti-tumor activities against CRC in vitro and in vivo. Bigelovin suppressed cell proliferation and colony formation and induced apoptosis in human colorectal cancer HT-29 and HCT 116 cells in vitro. Results also revealed that bigelovin activated caspases, caused the G2/M cell cycle arrest and induced DNA damage through up-regulation of death receptor (DR) 5 and increase of ROS. In HCT 116 xenograft model, bigelovin treatment resulted in suppression of tumor growth. Bigelovin at 20 mg/kg showed more significant tumor suppression and less side effects than conventional FOLFOX (containing folinic acid, 5-fluorouracil and oxaliplatin) treatment. In addition, in vivo data confirmed that anti-tumor activity of bigelovin in CRC was through induction of apoptosis by up-regulating DR5 and increasing ROS. In conclusion, these results strongly suggested that bigelovin has potential to be developed as therapeutic agent for CRC patients.
DOI10.1038/srep42176
Indexed BySCI
Language英语
WOS IDWOS:000393834100001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/41891
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.China Pharmaceut Univ, Sch Tradit Chinese Med, Nanjing 211198, Jiangsu, Peoples R China
4.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
5.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
6.Chinese Univ Hong Kong, Dept Surg, Shatin, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Li, Mingyue,Song, Li-Hua,Yue, Grace Gar-Lee,et al. Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species[J]. SCIENTIFIC REPORTS,2017,7(0):42176.
APA Li, Mingyue.,Song, Li-Hua.,Yue, Grace Gar-Lee.,Lee, Julia Kin-Ming.,Zhao, Li-Mei.,...&Lau, Clara Bik-San.(2017).Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species.SCIENTIFIC REPORTS,7(0),42176.
MLA Li, Mingyue,et al."Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species".SCIENTIFIC REPORTS 7.0(2017):42176.
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