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YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK 期刊论文
出版物, 3111, 期号: 0, 页码: 1-46
Authors:  Ling-Chu Chang;  Hui-Yi Lin;  Meng-Tung Tsai;  Ruey-Hwang Chou;  Fang-Yu Lee;  Che-Ming Teng;  Min-Tsang Hsieh;  Hsin-Yi Hung;  Li-Jiau Huang;  Yung-Luen Yu;  Sheng-Chu Kuo
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Yc-1  Triple-negative Breast Cancer  Erk  Ezh2  C-cbl  
Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity 期刊论文
PHYTOCHEMISTRY, 2022, 卷号: 193, 页码: 112970
Authors:  Li,Ya-Nan;  Zeng,Yan-Rong;  Yang,Jue;  He,Wenwen;  Chen,Junlei;  Deng,Lulu;  Yi,Ping;  Huang,Lie-Jun;  Gu,Wei;  Hu,Zhan-Xing;  Yuan,Chun-Mao;  Hao,Xiao-Jiang
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Hypericum monogynum L.  Hypericaceae  Chemical constituents  Polycyclic polyprenylated acylphloroglucinols  Flavonoids  COX-2 inhibitors  
PXR mediates mifepristone-induced hepatomegaly in mice 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 1, 页码: 146-156
Authors:  Yao,Xin-peng;  Jiao,Ting-ying;  Jiang,Yi-ming;  Fan,Shi-cheng;  Zhao,Ying-yuan;  Yang,Xiao;  Gao,Yue;  Li,Fei;  Zhou,Yan-ying;  Chen,Pan-pan;  Huang,Min;  Bi,Hui-chang
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mifepristone  hepatomegaly  pregnane X receptor (PXR)  yes-associated protein (YAP)  
Notoginsenoids, a new class of hexa-nortriterpenoids from biotransformation of Panax notoginseng saponins 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2022, 卷号: 1252, 页码: 132096
Authors:  Shang,Jia-Huan;  Li,Yong-Xiang;  Zhu,Hong-Tao;  Wang,Dong;  Qiao,Yi-Jun;  Yang,Chong-Ren;  Zhang,Ying-Jun
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Panax notoginseng saponins  Hexa-nortriterpenoids  Biotransformation  Antifungal activity  X-ray analysis  MICROBIAL TRANSFORMATION  ABSOLUTE-CONFIGURATION  20(S)-PROTOPANAXATRIOL  DIFFERENTIATION  BIOSYNTHESIS  MO-2(OAC)(4)  METABOLITES  
Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 3, 页码: 588-601
Authors:  Li,Xu-xia;  Zhang,Peng;  Yang,Yang;  Wang,Jing-jing;  Zheng,Yan-jun;  Tan,Ji-liang;  Liu,Shen-yan;  Yan,Yong-ming;  Zhang,You-yi;  Cheng,Yong-xian;  Yang,Huang-tian
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cardiac hypertrophy  pyrazine derivative  QF84139  phenylephrine  transverse aortic constriction  AMPK signaling pathway  PROTEIN-KINASE  MAMMALIAN TARGET  OVERLOAD  METFORMIN  MACROPHAGES  MECHANISMS  MEDICINE  ALPHA  CELLS  MODEL  
A 2-oxoglutarate-dependent dioxygenase converts dihydrofuran to furan in Salvia diterpenoids 期刊论文
PLANT PHYSIOLOGY, 2022, 卷号: 188, 期号: 3, 页码: 1496-1506
Authors:  Song,Jiao-Jiao;  Fang,Xin;  Li,Chen-Yi;  Jiang,Yan;  Li,Jian-Xu;  Wu,Sheng;  Guo,Juan;  Liu,Yan;  Fan,Hang;  Huang,Yan-Bo;  Wei,Yu-Kun;  Kong,Yu;  Zhao,Qing;  Xu,Jing-Jing;  Hu,Yong-Hong;  Chen,Xiao-Ya;  Yang,Lei
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MOLECULAR-CLONING  BIOSYNTHESIS  TANSHINONES  EVOLUTION  CYTOTOXICITY  SUPERFAMILY  OXYGENASES  APOPTOSIS  SYNTHASE  
Pesimquinolones I-S, eleven new quinolone alkaloids produced by Penicillium simplicissimum and their inhibitory activity on NO production 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 104635
Authors:  Dai,Chong;  Li,Xiaoxin;  Zhang,Kailin;  Li,Xiao-Nian;  Wang,Wenjing;  Zang,Yi;  Chen,Xia;  Li,Qin;  Wei,Mengsha;  Chen,Chunmei;  Zhu,Hucheng;  Zhang,Yonghui
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Penicillium simplicissimum  Quinolone alkaloids  inhibitory activity on NO production  
Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort 期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 12, 期号: 34, 页码: 11438-11446
Authors:  Guo,Yi;  Huang,Fang;  Sun,Weiguang;  Zhou,Yuan;  Chen,Chunmei;  Qi,Changxing;  Yang,Jing;  Li,Xiao-Nian;  Luo,Zengwei;  Zhu,Hucheng;  Wang,Xiaochuan;  Zhang,Yonghui
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AMYLOID-BETA  NEUROFIBRILLARY DEGENERATION  HYPERFORIN  NEUROTOXICITY  PATHOGENESIS  INHIBITION  BACE1  DRUG  TAU  
Protect China's karst cave habitats 期刊论文
SCIENCE, 2021, 卷号: 374, 期号: 6568, 页码: 698-698
Authors:  Duan,Yi-Fan;  Li,Meng;  Xu,Ke-Wang;  Zhang,Liang;  Zhang,Li-Bing
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GESNERIACEAE  GUIZHOU  
Genomic basis of high-altitude adaptation in Tibetan Prunus fruit trees 期刊论文
CURRENT BIOLOGY, 2021, 卷号: 31, 期号: 17, 页码: 3848+
Authors:  Wang,Xia;  Liu,Shengjun;  Zuo,Hao;  Zheng,Weikang;  Zhang,Shanshan;  Huang,Yue;  Pingcuo,Gesang;  Ying,Hong;  Zhao,Fan;  Li,Yuanrong;  Liu,Junwei;  Yi,Ting-Shuang;  Zan,Yanjun;  Larkin,Robert M.;  Deng,Xiuxin;  Zeng,Xiuli;  Xu,Qiang
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R-PACKAGE  PHYLOGENETIC ANALYSIS  ANALYSIS TOOLKIT  ANALYSIS REVEALS  WEB SERVER  SELECTION  ELEMENT  IDENTIFICATION  ALIGNMENT  ACCURATE