UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata

doi:10.1021/acs.jafc.3c04311

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	UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata
	Wang,Peng; Yang,Xiao-Meng; Hu,Zhan-Xing; Li,Ya-Nan; Yang,Jue; Hao,Xiao-Jiang; Yuan,Chun-Mao; Yi,Ping
	2023
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	1520-5118
卷号	71 期号:44 页码:16581-16592
摘要	Physalis angulata Linn. is an exotic Amazonian fruit that is commonly recognized as wild tomato, winter cherry, and gooseberry. While its fruit is known to contain many nutrients, such as minerals, fibers, and vitamins, few papers have investigated withanolide derivatives from its fruits. UPLC-Q-Orbitrap-MS/MS, which produces fragmentation spectra, was applied for the first time to guide the isolation of bioactive withanolide derivatives from P. angulata fruits. As a result, twenty-six withanolide derivatives, including two novel 1,10-secowithanolides (1 and 2) and a new derivative (3), were obtained. Compounds 1 and 2 are rare rearranged 1,10-secowithanolides with a tetracyclic 7/6/6/5 ring system. All structures were assigned through various spectroscopic data and quantum chemical calculations. Nine withanolide derivatives exhibited significant inhibitory effects on three tumor cell lines with IC50 values of 0.51-13.79 mu M. Moreover, three new compounds (1-3) exhibited potential nitric oxide inhibitory effects in lipopolysaccharide-stimulated RAW264.7 cells (IC50: 7.51-61.8 mu M). This investigation indicated that fruits of P. angulata could be applied to treat and prevent cancer and inflammatory-related diseases due to their potent active withanolide derivatives.
关键词	Physalis angulata rare withanolidederivatives isolation and identification anticancer anti-inflammatory activity CYTOTOXIC WITHANOLIDES CONSTITUENTS PLANTS L.
DOI	10.1021/acs.jafc.3c04311
收录类别	SCI
WOS记录号	WOS:001096867200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75300
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Peng,Yang,Xiao-Meng,Hu,Zhan-Xing,et al. UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(44):16581-16592.
APA	Wang,Peng.,Yang,Xiao-Meng.,Hu,Zhan-Xing.,Li,Ya-Nan.,Yang,Jue.,...&Yi,Ping.(2023).UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(44),16581-16592.
MLA	Wang,Peng,et al."UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.44(2023):16581-16592.

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