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| Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities | |
Yang,Li-Yuan; Yi,Ping; Chen,Jun-Lei; Li,Yu-Huan; Qiu,Jue-Lin; Wang,Zhao-Yang; Fu,Mao; Yuan,Chun-Mao; Huang,Lie-Jun; Hao,Xiao-Jiang ; Gu,Wei
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| 2023 | |
| Source Publication | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1880 |
| Abstract | Two new ursane-type triterpenes, eburnealactones A and B (1 and 2), one new flavonoid, eburneatin A (6), and one new phenylethanoid glycoside, chiritoside D (7), along with 9 known compounds (3-5, 8-13) were isolated from the whole plant of Primulina eburnea. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, and HR-ESI-MS). All the compounds were evaluated for their cytotoxic activities. Compound 1 showed significant cytotoxic activities against MKN-45 cell lines and 5637 cell lines with the IC50 values of 9.57 mu M and 8.30 mu M, respectively. Compound 1 exhibited moderate cytotoxic activities against A549 and PATU8988T cell lines with the IC50 values of 30.70 mu M and 38.22 mu M, respectively. Compound 6 exhibited moderate cytotoxic activities against MKN-45, HCT116, PATU8988T, 5637 and A-673 cell lines with the IC50 values of 19.69 mu M, 16.44 mu M, 18.07 mu M, 11.51 mu M and 18.15 mu M, respectively. Compound 5 showed moderate cytotoxic activities against A549 cell lines with the IC50 values of 24.06 mu M. |
| Keyword | Primulina eburnea triterpenes flavonoids phenylethanoid glycosides cytotoxic activity GLUCOSIDES LEAVES CELL |
| Subject Area | Biochemistry & Molecular Biology ; Chemistry |
| DOI | 10.1002/cbdv.202300248 |
| Indexed By | SCI |
| WOS ID | WOS:000981527100001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/75326 |
| Collection | 中国科学院昆明植物研究所 |
| Recommended Citation GB/T 7714 | Yang,Li-Yuan,Yi,Ping,Chen,Jun-Lei,et al. Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities[J]. CHEMISTRY & BIODIVERSITY,2023. |
| APA | Yang,Li-Yuan.,Yi,Ping.,Chen,Jun-Lei.,Li,Yu-Huan.,Qiu,Jue-Lin.,...&Gu,Wei.(2023).Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities.CHEMISTRY & BIODIVERSITY. |
| MLA | Yang,Li-Yuan,et al."Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities".CHEMISTRY & BIODIVERSITY (2023). |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| 10.1002_cbdv.2023002（1860KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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