Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities

doi:10.1002/cbdv.202300248

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	Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities
	Yang,Li-Yuan; Yi,Ping; Chen,Jun-Lei; Li,Yu-Huan; Qiu,Jue-Lin; Wang,Zhao-Yang; Fu,Mao; Yuan,Chun-Mao; Huang,Lie-Jun; Hao,Xiao-Jiang; Gu,Wei
	2023
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1880
摘要	Two new ursane-type triterpenes, eburnealactones A and B (1 and 2), one new flavonoid, eburneatin A (6), and one new phenylethanoid glycoside, chiritoside D (7), along with 9 known compounds (3-5, 8-13) were isolated from the whole plant of Primulina eburnea. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, and HR-ESI-MS). All the compounds were evaluated for their cytotoxic activities. Compound 1 showed significant cytotoxic activities against MKN-45 cell lines and 5637 cell lines with the IC50 values of 9.57 mu M and 8.30 mu M, respectively. Compound 1 exhibited moderate cytotoxic activities against A549 and PATU8988T cell lines with the IC50 values of 30.70 mu M and 38.22 mu M, respectively. Compound 6 exhibited moderate cytotoxic activities against MKN-45, HCT116, PATU8988T, 5637 and A-673 cell lines with the IC50 values of 19.69 mu M, 16.44 mu M, 18.07 mu M, 11.51 mu M and 18.15 mu M, respectively. Compound 5 showed moderate cytotoxic activities against A549 cell lines with the IC50 values of 24.06 mu M.
关键词	Primulina eburnea triterpenes flavonoids phenylethanoid glycosides cytotoxic activity GLUCOSIDES LEAVES CELL
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.1002/cbdv.202300248
收录类别	SCI
WOS记录号	WOS:000981527100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75326
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yang,Li-Yuan,Yi,Ping,Chen,Jun-Lei,et al. Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities[J]. CHEMISTRY & BIODIVERSITY,2023.
APA	Yang,Li-Yuan.,Yi,Ping.,Chen,Jun-Lei.,Li,Yu-Huan.,Qiu,Jue-Lin.,...&Gu,Wei.(2023).Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities.CHEMISTRY & BIODIVERSITY.
MLA	Yang,Li-Yuan,et al."Chemical Constituents of Primulina eburnea (Gesneriaceae) and Their Cytotoxic Activities".CHEMISTRY & BIODIVERSITY (2023).

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