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Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 3, 页码: 588-601
Authors:  Li,Xu-xia;  Zhang,Peng;  Yang,Yang;  Wang,Jing-jing;  Zheng,Yan-jun;  Tan,Ji-liang;  Liu,Shen-yan;  Yan,Yong-ming;  Zhang,You-yi;  Cheng,Yong-xian;  Yang,Huang-tian
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cardiac hypertrophy  pyrazine derivative  QF84139  phenylephrine  transverse aortic constriction  AMPK signaling pathway  PROTEIN-KINASE  MAMMALIAN TARGET  OVERLOAD  METFORMIN  MACROPHAGES  MECHANISMS  MEDICINE  ALPHA  CELLS  MODEL  
New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity 期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 6, 页码: 1648-1666
Authors:  Su,Lihua;  Zhang,Xintian;  Ma,Yunbao;  Geng,Changan;  Huang,Xiaoyan;  Hu,Jing;  Li,Tianze;  Tang,Shuang;  Shen,Cheng;  Gao,Zhen;  Zhang,Xuemei;  Chen,Ji-Jun
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Guaianolide dimers  Artematrolides AeR  Artemisia atrovirens  Cytotoxicity  Cell cycle  Apoptosis  FARNESYL-PROTEIN TRANSFERASE  CELL-CYCLE ARREST  HEPATOCELLULAR-CARCINOMA  GUAIANOLIDES  LACTONES  INHIBITORS  ARTEMINOLIDE  APOPTOSIS  ARGYI  HELA  
Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 105072
Authors:  Su,Li-Hua;  Ma,Yun-Bao;  Geng,Chang-An;  Li,Tian-Ze;  Huang,Xiao-Yan;  Hu,Jing;  Zhang,Xin;  Tang,Shuang;  Shen,Cheng;  Gao,Zhen;  Zhang,Xue-Mei;  Chen,Ji-Jun
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Artemisia atrovirens  guaiane-type sesquiterpenoids  artematrovirenins A-P  HepG2 and Huh7 cell lines  antihepatic cytotoxicity  LACTONES  CONSTITUENTS  GUAIANOLIDES  
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 127994
Authors:  Wang,Jin-Ping;  Li,Tian-Ze;  Huang,Xiao-Yan;  Geng,Chang-An;  Shen,Cheng;  Sun,Jin-Jin;  Xue,Dong;  Chen,Ji-Jun
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Santamarin derivatives  Anti-fibrotic effects  HSC-LX2  Extracellular matrix  NF-KAPPA-B  SESQUITERPENE LACTONES  LIVER FIBROSIS  STRUCTURE REQUIREMENT  BAY LEAF  ACTIVATION  
Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 卷号: 23, 期号: 8, 页码: 772-780
Authors:  Zi,Cheng-Ting;  Yang,Liu;  Hu,Yue;  Zhang,Pan;  Tang,Han;  Zhang,Bang-Lei;  Shen,Xiao-Jing;  Kong,Qing-Hua;  Wang,Ya;  Wang,Xuan-Jun;  Sheng,Jun
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Podophyllotixin  EGCG  click reaction  antitumor activity  molecular docking  PODOPHYLLOTOXIN  DERIVATIVES  CONGENERS  
Transcriptomes of Saussurea (Asteraceae) Provide Insights into High-Altitude Adaptation 期刊论文
PLANTS-BASEL, 2021, 卷号: 10, 期号: 8, 页码: 1715
Authors:  Zhang,Xu;  Sun,Yanxia;  Landis,Jacob B.;  Shen,Jun;  Zhang,Huajie;  Kuang,Tianhui;  Sun,Wenguang;  Sun,Jiao;  Tiamiyu,Bashir B.;  Deng,Tao;  Sun,Hang;  Wang,Hengchang
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high-altitude adaptation  Saussurea  transcriptomes  positive selection  extreme environments  lineage-specific genes  RNA-SEQ  HENGDUAN MOUNTAINS  STRESS ACCLIMATION  SEQUENCE ALIGNMENT  HIGH ELEVATIONS  METABOLISM  GENOME  ANNOTATION  EVOLUTION  SELECTION  
Artemyrianolides A-S, Cytotoxic Sesquiterpenoids from Artemisia myriantha 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2020
Authors:  Tang, Shuang;  Zhang, Xin-Tian;  Ma, Yun-Bao;  Huang, Xiao-Yan;  Geng, Chang-An;  Li, Tian-Ze;  Zhang, Xue-Mei;  Shen, Cheng;  Su, Li-Hua;  Gao, Zhen;  Chen, Ji-Jun
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Plastome Evolution in Dolomiaea (Asteraceae, Cardueae) Using Phylogenomic and Comparative Analyses 期刊论文
FRONTIERS IN PLANT SCIENCE, 2020
Authors:  Shen, Jun;  Zhang, Xu;  Landis, Jacob B.;  Zhang, Huajie;  Deng, Tao;  Sun, Hang;  Wang, Hengchang
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Plastome phylogenomic study of Gentianeae (Gentianaceae): widespread gene tree discordance and its association with evolutionary rate heterogeneity of plastid genes 期刊论文
BMC PLANT BIOLOGY, 2020
Authors:  Zhang, Xu;  Sun, Yanxia;  Landis, Jacob B.;  Lv, Zhenyu;  Shen, Jun;  Zhang, Huajie;  Lin, Nan;  Li, Lijuan;  Sun, Jiao;  Deng, Tao;  Sun, Hang;  Wang, Hengchang
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Cytotoxic sesquiterpenoids against hepatic stellate cell line LX2 from Artemisia lavandulaefolia 期刊论文
BIOORGANIC CHEMISTRY, 2020
Authors:  Shen, Cheng;  Huang, Xiao-Yan;  Geng, Chang-An;  Li, Tian-Ze;  Wang, Jin-Ping;  Tang, Shuang;  Su, Li-Hua;  Gao, Zhen;  Zhang, Xue-Mei;  Chen, Ji-Jun
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