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Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens
Su,Li-Hua; Ma,Yun-Bao; Geng,Chang-An; Li,Tian-Ze; Huang,Xiao-Yan; Hu,Jing; Zhang,Xin; Tang,Shuang; Shen,Cheng; Gao,Zhen; Zhang,Xue-Mei; Chen,Ji-Jun
2021
Source PublicationBIOORGANIC CHEMISTRY
ISSN0045-2068
Volume114Pages:105072
AbstractRandom screening revealed that the EtOH extract of Artemisia atrovirens showed significant cytotoxicity against two human hepatoma cell lines (HepG2 and Huh7) with the inhibitory ratio of 98.9% and 99.7% at the concentration of 100 mu g/mL. Further bioactivity-guided isolation of active fraction led to 16 new guaiane-type sesquiterpenoids, artematrovirenins A-P (1-16). Their structures were elucidated by extensive spectroscopic data. The absolute stereochemistry of compounds 1 and 14 was determined by single-crystal X-ray diffraction analyses. Pharmacological evaluation suggested that five compounds (3, 5, 8, 10, and 15) exhibited cytotoxicity, compounds 3 and 5 displayed cytotoxicity against HepG2 cell line with an IC50 values of 8.0 and 16.0 mu M, as well as against Huh7 cell line with values of 18.2 and 32.2 mu M.
KeywordArtemisia atrovirens guaiane-type sesquiterpenoids artematrovirenins A-P HepG2 and Huh7 cell lines antihepatic cytotoxicity LACTONES CONSTITUENTS GUAIANOLIDES
DOI10.1016/j.bioorg.2021.105072
WOS IDWOS:000689510400006
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73754
Collection中国科学院昆明植物研究所
Affiliation1.[Su, Li-Hua
2.Ma, Yun-Bao
3.Geng, Chang-An
4.Li, Tian-Ze
5.Huang, Xiao-Yan
6.Hu, Jing
7.Zhang, Xin
8.Tang, Shuang
9.Shen, Cheng
10.Gao, Zhen
11.Zhang, Xue-Mei
12.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
13.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Su,Li-Hua,Ma,Yun-Bao,Geng,Chang-An,et al. Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens[J]. BIOORGANIC CHEMISTRY,2021,114:105072.
APA Su,Li-Hua.,Ma,Yun-Bao.,Geng,Chang-An.,Li,Tian-Ze.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens.BIOORGANIC CHEMISTRY,114,105072.
MLA Su,Li-Hua,et al."Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens".BIOORGANIC CHEMISTRY 114(2021):105072.
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