Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens

doi:10.1016/j.bioorg.2021.105072

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	Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens
	Su,Li-Hua ; Ma,Yun-Bao ; Geng,Chang-An ; Li,Tian-Ze ; Huang,Xiao-Yan ; Hu,Jing ; Zhang,Xin ; Tang,Shuang ; Shen,Cheng ; Gao,Zhen ; Zhang,Xue-Mei ; Chen,Ji-Jun
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	114 页码:105072
摘要	Random screening revealed that the EtOH extract of Artemisia atrovirens showed significant cytotoxicity against two human hepatoma cell lines (HepG2 and Huh7) with the inhibitory ratio of 98.9% and 99.7% at the concentration of 100 mu g/mL. Further bioactivity-guided isolation of active fraction led to 16 new guaiane-type sesquiterpenoids, artematrovirenins A-P (1-16). Their structures were elucidated by extensive spectroscopic data. The absolute stereochemistry of compounds 1 and 14 was determined by single-crystal X-ray diffraction analyses. Pharmacological evaluation suggested that five compounds (3, 5, 8, 10, and 15) exhibited cytotoxicity, compounds 3 and 5 displayed cytotoxicity against HepG2 cell line with an IC50 values of 8.0 and 16.0 mu M, as well as against Huh7 cell line with values of 18.2 and 32.2 mu M.
关键词	Artemisia atrovirens guaiane-type sesquiterpenoids artematrovirenins A-P HepG2 and Huh7 cell lines antihepatic cytotoxicity LACTONES CONSTITUENTS GUAIANOLIDES
DOI	10.1016/j.bioorg.2021.105072
WOS记录号	WOS:000689510400006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73754
专题	中国科学院昆明植物研究所
作者单位	1.[Su, Li-Hua 2.Ma, Yun-Bao 3.Geng, Chang-An 4.Li, Tian-Ze 5.Huang, Xiao-Yan 6.Hu, Jing 7.Zhang, Xin 8.Tang, Shuang 9.Shen, Cheng 10.Gao, Zhen 11.Zhang, Xue-Mei 12.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 13.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Su,Li-Hua,Ma,Yun-Bao,Geng,Chang-An,et al. Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens[J]. BIOORGANIC CHEMISTRY,2021,114:105072.
APA	Su,Li-Hua.,Ma,Yun-Bao.,Geng,Chang-An.,Li,Tian-Ze.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens.BIOORGANIC CHEMISTRY,114,105072.
MLA	Su,Li-Hua,et al."Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens".BIOORGANIC CHEMISTRY 114(2021):105072.

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