Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens

doi:10.1016/j.bioorg.2021.105072

KIB OpenIR

	Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens
	Su,Li-Hua ; Ma,Yun-Bao ; Geng,Chang-An ; Li,Tian-Ze ; Huang,Xiao-Yan ; Hu,Jing ; Zhang,Xin ; Tang,Shuang ; Shen,Cheng ; Gao,Zhen ; Zhang,Xue-Mei ; Chen,Ji-Jun
	2021
Source Publication	BIOORGANIC CHEMISTRY
ISSN	0045-2068
Volume	114 Pages:105072
Abstract	Random screening revealed that the EtOH extract of Artemisia atrovirens showed significant cytotoxicity against two human hepatoma cell lines (HepG2 and Huh7) with the inhibitory ratio of 98.9% and 99.7% at the concentration of 100 mu g/mL. Further bioactivity-guided isolation of active fraction led to 16 new guaiane-type sesquiterpenoids, artematrovirenins A-P (1-16). Their structures were elucidated by extensive spectroscopic data. The absolute stereochemistry of compounds 1 and 14 was determined by single-crystal X-ray diffraction analyses. Pharmacological evaluation suggested that five compounds (3, 5, 8, 10, and 15) exhibited cytotoxicity, compounds 3 and 5 displayed cytotoxicity against HepG2 cell line with an IC50 values of 8.0 and 16.0 mu M, as well as against Huh7 cell line with values of 18.2 and 32.2 mu M.
Keyword	Artemisia atrovirens guaiane-type sesquiterpenoids artematrovirenins A-P HepG2 and Huh7 cell lines antihepatic cytotoxicity LACTONES CONSTITUENTS GUAIANOLIDES
DOI	10.1016/j.bioorg.2021.105072
WOS ID	WOS:000689510400006
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73754
Collection	中国科学院昆明植物研究所
Affiliation	1.[Su, Li-Hua 2.Ma, Yun-Bao 3.Geng, Chang-An 4.Li, Tian-Ze 5.Huang, Xiao-Yan 6.Hu, Jing 7.Zhang, Xin 8.Tang, Shuang 9.Shen, Cheng 10.Gao, Zhen 11.Zhang, Xue-Mei 12.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 13.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Su,Li-Hua,Ma,Yun-Bao,Geng,Chang-An,et al. Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens[J]. BIOORGANIC CHEMISTRY,2021,114:105072.
APA	Su,Li-Hua.,Ma,Yun-Bao.,Geng,Chang-An.,Li,Tian-Ze.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens.BIOORGANIC CHEMISTRY,114,105072.
MLA	Su,Li-Hua,et al."Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens".BIOORGANIC CHEMISTRY 114(2021):105072.

Files in This Item:
File Name/Size	DocType	Version	Access	License
005-A05-011-2021-苏丽花（2611KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	View Application Full Text

File name:	005-A05-011-2021-苏丽花-BC.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院昆明植物研究所知识管理系统