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Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates
Zi,Cheng-Ting; Yang,Liu; Hu,Yue; Zhang,Pan; Tang,Han; Zhang,Bang-Lei; Shen,Xiao-Jing; Kong,Qing-Hua; Wang,Ya; Wang,Xuan-Jun; Sheng,Jun
2021
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN1028-6020
卷号23期号:8页码:772-780
摘要Two new (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates (7and8) were synthesized and evaluated for biological activity. Compound8showed highly potent anticancer activity against A-549 cell line with IC(50)of 2.16 +/- 1.02 mu M, which displayed the highest selectivity index value (SI = 14.5) in A-549 cells. Molecular docking indicated that compound8could bind with the active site of Top-II. Therefore, compound8might be a promising candidate for further development.
关键词Podophyllotixin EGCG click reaction antitumor activity molecular docking PODOPHYLLOTOXIN DERIVATIVES CONGENERS
DOI10.1080/10286020.2020.1786066
WOS记录号WOS:000546364300001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73241
专题中国科学院昆明植物研究所
作者单位1.[Zi, Cheng-Ting
2.Hu, Yue
3.Zhang, Pan
4.Tang, Han
5.Zhang, Bang-Lei
6.Wang, Ya
7.Wang, Xuan-Jun
8.Yunnan Agr Univ, Key Lab Pu Er Tea Sci, Minist Educ, Kunming 650201, Yunnan, Peoples R China
9.Shen, Xiao-Jing
10.Yunnan Agr Univ, Coll Sci, Kunming 650201, Yunnan, Peoples R China
11.[Yang, Liu
12.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Zi,Cheng-Ting,Yang,Liu,Hu,Yue,et al. Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2021,23(8):772-780.
APA Zi,Cheng-Ting.,Yang,Liu.,Hu,Yue.,Zhang,Pan.,Tang,Han.,...&Sheng,Jun.(2021).Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,23(8),772-780.
MLA Zi,Cheng-Ting,et al."Synthesis, antitumor activity, and molecular docking of (-)-epigallocatechin-3-gallate-4 beta-triazolopodophyllotoxin conjugates".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 23.8(2021):772-780.
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