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Design and synthesis of novel artemisinin hybrids with potent activities against human colorectal cancer cells in vitro and in vivo (vol 182, 111665, 2019) 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 194, 页码: 1
Authors:  Wang, Liang-Liang;  Kong, Lingmei;  Liu, Hui;  Zhang, Yunqin;  Zhang, Li;  Liu, Xingyong;  Yuan, Feng;  Li, Yan;  Zuo, Zhili
Favorite  |  View/Download:21/0  |  Submit date:2020/05/27
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 11, 页码: 3576-3589
Authors:  Li, Xue;  Kong, Lingmei;  Yang, Qihong;  Duan, Aizhu;  Ju, Xiaoman;  Cai, Bicheng;  Chen, Lin;  An, Tao;  Li, Yan
Favorite  |  View/Download:4/0  |  Submit date:2020/06/08
small molecule  deubiquitylation (deubiquitination)  Wnt signaling  pharmacology  enzyme inhibitor  ?-catenin  parthenolide  ubiquitination  USP7  Wnt signaling  ubiquitin-specific peptidase 7  colorectal cancer  proteasome system  protein homeostasis  deubiquitinating activity  
Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 10
Authors:  Wang, Liang-Liang;  Kong, Lingmei;  Liu, Hui;  Zhang, Yunqin;  Zhang, Li;  Liu, Xingyong;  Yuan, Feng;  Li, Yan;  Zuo, Zhili
Favorite  |  View/Download:23/0  |  Submit date:2020/03/02
Artemisinin  Quinazoline  Hybridization  Colorectal cancer  Chemotherapy  
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer 期刊论文
BIOLOGY OPEN, 2019, 卷号: 8, 期号: 11, 页码: 9
Authors:  Duan, Aizhu;  Kong, Lingmei;  An, Tao;  Zhou, Hongyu;  Yu, Chunlei;  Li, Yan
View  |  Adobe PDF(2302Kb)  |  Favorite  |  View/Download:21/3  |  Submit date:2020/03/02
Star-PAP  TPD52  miR-449a  miR-34a  Breast cancer  
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin 期刊论文
CELL CHEMICAL BIOLOGY, 2019, 卷号: 26, 期号: 8, 页码: 1122-+
Authors:  Zhu, Huifang;  Wang, Bin;  Kong, Lingmei;  An, Tao;  Li, Gentao;  Zhou, Hongyu;  Gong, Liang;  Zhao, Zhangxun;  Gong, Yaxiao;  Sun, Handong;  Puno, Pematenzin;  Li, Yan
View  |  Adobe PDF(4600Kb)  |  Favorite  |  View/Download:43/3  |  Submit date:2019/10/14
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
Authors:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
View  |  Adobe PDF(5225Kb)  |  Favorite  |  View/Download:71/3  |  Submit date:2019/06/24
Aurovertin B sensitizes colorectal cancer cells to NK cell recognition and lysis 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 503, 期号: 4, 页码: 3057-3063
Authors:  Zhu, Huifang;  Wang, Fei;  Ju, Xiaoman;  Kong, Lingmei;  An, Tao;  Zhao, Zhangxun;  Liu, Jikai;  Li, Yan
Favorite  |  View/Download:336/0  |  Submit date:2018/10/22
Aurovertin B  Cytotoxicity  Immunotherapy  NK cell  NKG2D ligands  
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2017, 卷号: 131, 期号: 1, 页码: 29-39
Authors:  An, Tao;  Gong, Yaxiao;  Li, Xue;  Kong, Lingmei;  Ma, Pengcheng;  Gong, Liang;  Zhu, Huifang;  Yu, Chunlei;  Liu, Jianmei;  Zhou, Hongyu;  Mao, Bingyu;  Li, Yan
View  |  Adobe PDF(3138Kb)  |  Favorite  |  View/Download:658/117  |  Submit date:2017/04/06
Usp7 Inhibitor  Wnt Signaling  Colorectal Cancer  
应用靶向分离技术挖掘黄海棠中的 PPAP 类成分 学位论文
: 中国科学院大学, 2017
Authors:  孔令梅
Adobe PDF(10440Kb)  |  Favorite  |  View/Download:50/3  |  Submit date:2019/06/14
Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2016, 卷号: 116, 页码: 39-50
Authors:  Zhou, Hongyu;  Shang, Chaowei;  Wang, Min;  Shen, Tao;  Kong, Lingmei;  Yu, Chunlei;  Ye, Zhennan;  Luo, Yan;  Liu, Lei;  Li, Yan;  Huang, Shile
View  |  Adobe PDF(3794Kb)  |  Favorite  |  View/Download:86/7  |  Submit date:2017/01/05
Ciclopirox  Mtor  Ampk  Tsc2  Raptor