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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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Discovery of novel modulators targeting human TRPC5: Docking-based virtual screening, molecular dynamics simulation and binding af fi nity predication
期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 102, 页码: 107795
Authors:
Liu,Bin
;
Zhang,Wei
;
Guo,Sheng
;
Zuo,Zhili
Adobe PDF(4277Kb)
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Submit date:2022/04/02
hTRPC5
Homology modeling
Molecular docking
Molecular dynamics simulation
Virtual screening
INHIBITOR
CHANNELS
GROMACS
POTENT
AMBER
IDENTIFICATION
CONSTRAINTS
INTEGRATION
AMYGDALA
Identification of Novel TRPC5 Inhibitors by Pharmacophore-Based and Structure-Based Approaches
期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020
Authors:
Li, Shuxiang
;
Zhang, Shuqun
;
Chen, Dingyuan
;
Jiang, Xuan
;
Liu, Bin
;
Zhang, Hongbin
;
Rachakunta, Munikishore
;
Zuo, Zhili
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Submit date:2021/01/05
Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis
期刊论文
FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2019, 卷号: 13, 页码: 17
Authors:
Guo, Ying
;
Xie, Jian-Ping
;
Deng, Ke
;
Li, Xia
;
Yuan, Yun
;
Xuan, Qun
;
Xie, Jing
;
He, Xiao-Ming
;
Wang, Qian
;
Li, Juan-Juan
;
Luo, Huai-Rong
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Submit date:2019/07/29
Bifidobacterium adolescentis
antidepressant
chronic restraint stress
gut microbiota
inflammation
双歧杆菌的抗抑郁作用与肠-脑轴相关机制研究
学位论文
博士: 中国科学院昆明植物研究所, 2019
Authors:
郭英
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Submit date:2022/08/29
抑郁
双歧杆菌
肠道菌群
海马
炎性细胞因子
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
Authors:
Qu, Chunrong
;
Ding, Mingmin
;
Zhu, Yingmin
;
Lu, Yungang
;
Du, Juan
;
Miller, Melissa
;
Tian, Jinbin
;
Zhu, Jinmei
;
Xui, Jian
;
Wen, Meng
;
Er-Bu, Aga
;
Wan, Jule
;
Xiao, Yuling
;
Wu, Meng
;
McManus, Owen B.
;
Li, Min
;
Wu, Jilin
;
Luo, Huai-Rong
;
Cao, Zhengyu
;
Shen, Bing
;
Wang, Hongbo
;
Zhu, Michael X.
;
Hong, Xuechuan
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Submit date:2017/08/29
M084抗衰老机制及WWP-1调控脂代谢与衰老机制的研究
学位论文
: 中国科学院大学, 2017
Authors:
丁爱军
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Submit date:2019/06/14
小鼠杏仁中央核逆向投射的研究
学位论文
: 中国科学院大学, 2017
Authors:
谢静
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Submit date:2019/06/14
Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way
期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2017, 卷号: 426, 期号: 1-2, 页码: 101-109
Authors:
Ding, Ai-Jun
;
Wu, Gui-Sheng
;
Tang, Bin
;
Hong, Xuechuan
;
Zhu, Michael X.
;
Luo, Huai-Rong
Adobe PDF(557Kb)
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Submit date:2017/05/19
Aging
Benzimidazole Derivative M084
Caenorhabditis Elegans
Lifespan
Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice
期刊论文
PLOS ONE, 2015, 卷号: 10, 期号: 8
Authors:
Yang, Li-Ping
;
Jiang, Fang-Jie
;
Wu, Gui-Sheng
;
Deng, Ke
;
Wen, Meng
;
Zhou, Xiaoju
;
Hong, Xuechuan
;
Zhu, Michael X.
;
Luo, Huai-Rong
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Submit date:2016/01/19
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 14, 页码: 3495-3509
Authors:
Zhu, Yingmin
;
Lu, Yungang
;
Qu, Chunrong
;
Miller, Melissa
;
Tian, Jinbin
;
Thakur, Dhananjay P.
;
Zhu, Jinmei
;
Deng, Zixin
;
Hu, Xianming
;
Wu, Meng
;
McManus, Owen B.
;
Li, Min
;
Hong, Xuechuan
;
Zhu, Michael X.
;
Luo, Huai-Rong
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Submit date:2015/12/15