Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis
Guo, Ying1,2,3,4; Xie, Jian-Ping5; Deng, Ke1,4; Li, Xia3; Yuan, Yun3; Xuan, Qun3; Xie, Jing1; He, Xiao-Ming1; Wang, Qian3; Li, Juan-Juan3; Luo, Huai-Rong1,2,4
Corresponding AuthorGuo, Ying(guoying1@mail.kib.ac.cn) ; Luo, Huai-Rong(luohuairong@mail.kib.ac.cn)
2019-06-18
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
Volume13Pages:17
AbstractStress disturbs the balance of the gut microbiota and stimulates inflammationto-brain mechanisms. Moreover, stress leads to anxiety and depressive disorders. Bifidobacterium adolescentis displays distinct anti-inflammatory effects. However, no report has focused on the anxiolytic and antidepressant effects of B. adolescentis related to the gut microbiome and the inflammation on chronic restraint stress (CRS) in mice. We found that pretreatment with B. adolescentis increased the time spent in the center of the open field apparatus, increased the percentage of entries into the open arms of the elevated plus-maze (EPM) and the percentage of time spent in the open arms of the EPM, and decreased the immobility duration in the tail suspension test as well as the forced swimming test (FST). Moreover, B. adolescentis increased the sequence proportion of Lactobacillus and reduced the sequence proportion of Bacteroides in feces. Furthermore, B. adolescentis markedly reduced the protein expression of interleukin-1 beta (IL-1 beta), tumor necrosis factor a (TNF-alpha), p-nuclear factor-kappa B (NF-kappa B) p65 and Iba1 and elevated brain derived neurotrophic factor (BDNF) expression in the hippocampus. We conclude that the anxiolytic and antidepressant effects of B. adolescentis are related to reducing inflammatory cytokines and rebalancing the gut microbiota.
KeywordBifidobacterium adolescentis antidepressant chronic restraint stress gut microbiota inflammation
DOI10.3389/fnbeh.2019.00126
Indexed BySCI
Language英语
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000471894400001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67178
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorGuo, Ying; Luo, Huai-Rong
Affiliation1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
2.Southwest Med Univ, Key Lab Aging & Regenerat Med, Dept Pharmacol, Sch Pharm, Luzhou, Peoples R China
3.Kunming Med Univ, Sch Basic Med Sci, Kunming, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Yunnan Minzu Univ, Lib, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Guo, Ying,Xie, Jian-Ping,Deng, Ke,et al. Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2019,13:17.
APA Guo, Ying.,Xie, Jian-Ping.,Deng, Ke.,Li, Xia.,Yuan, Yun.,...&Luo, Huai-Rong.(2019).Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,13,17.
MLA Guo, Ying,et al."Prophylactic Effects of Bifidobacterium adolescentis on Anxiety and Depression-Like Phenotypes After Chronic Stress: A Role of the Gut Microbiota-Inflammation Axis".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 13(2019):17.
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